Engineering A Bacterial Flagella Forest For Sensing And Actuation – A Progress Report, 2019 Southern Methodist University
Engineering A Bacterial Flagella Forest For Sensing And Actuation – A Progress Report, Xihe Liu, Shulin Ye, Isaac Oti, Lauren Metzinger
SMU Journal of Undergraduate Research
Flagella can be used to make magnetically-controlled microfluidic and nanoscale devices for biomedical applications in both vitro and vivo environments. They are capable of operating with high precision on the cellular and subcellular level. So far, scientists and engineers have successfully used monolithic inorganic materials or photoactive polymers  to mimic the helical bacterial flagella whose rotary-propulsion mechanism effectively overcomes the dominant viscous forces that prevail in a low Reynolds-number environment. Here, we focus on bacterial flagella and their rotary motion. The bacterial flagellum is an ideal biomaterial for constructing self-propelling nanoswimmers because it can reversibly change its geometry in ...
Engineering Success On The Field: A Reflection On The Epics Ironman Pediatric Prosthetic Project, 2018 Purdue University
Engineering Success On The Field: A Reflection On The Epics Ironman Pediatric Prosthetic Project, Glynn Gallaway
Purdue Journal of Service-Learning and International Engagement
Glynn Gallaway is a student in the Purdue Mechanical Engineering Class of 2020 with interests in the health care, assistive technology, and medical device industries. Glynn is from Dallas, Texas, and was inspired to pursue this career path through her interactions with youth with special needs. She joined the EPICS Ironman team in the fall of 2016 during her first year at Purdue as a part of the learning community. In this article, she discusses her experiences on the Ironman team creating a pediatric prosthetic for a young local athlete. The goal of the Ironman team is to create a ...
Esense 2.0: Modeling Biomimetic Predation With Multi-Agent Multi-Team Distributed Artificial Intelligence, 2018 Kennesaw State University
Esense 2.0: Modeling Biomimetic Predation With Multi-Agent Multi-Team Distributed Artificial Intelligence, D. Michael Franklin, Derek Martin
Georgia Undergraduate Research Conference (GURC)
Biologic predation is a complex interaction amongst sets of predators and prey operating within the same environment. There are many disparate factors for each member of each set to consider as they interact. Additionally, they each must seek food while avoiding other predators, meaning that they must prioritize their actions based on policies. eSense provides a powerful yet simplistic reinforcement learning algorithm that employs model-based behavior across multiple learning layers. These independent layers split the learning objectives across multiple layers, avoiding the learning-confusion common in many multi-agent systems. The new eSense 2.0 increases the number of layers and the ...
Lanthanide Ions Doped In Vanadium Oxide For Sensitive Optical Glucose Detection, 2018 Texas A&M University, College Station
Lanthanide Ions Doped In Vanadium Oxide For Sensitive Optical Glucose Detection, Ansam J. Talib, Masfer Alkahtani, Linkun Jiang, Fahad Alghannam, Robert Brick, Carmen L. Gomes, Marlan O. Scully, Alexei V. Sokolov, Philip R. Hemmer
Mechanical Engineering Publications
Blood glucose monitoring is essential to avoid the unwanted consequences of glucose level fluctuations. Optical monitors are of special interest because they can be non-invasive. Among optical glucose sensors, fluorescent upconversion nanoparticles (UCNPs) have the advantage of good photostability, low toxicity, and exceptional autofluorescence suppression. However, to sense glucose, UCNPs normally need surface functionalization, and this can be easily affected by other factors in biological systems, and may also affect their ability for real-time sensing of both increasing and decreasing glucose levels. Here, we report YVO4 : Yb3+, Er3+@Nd3+core/shell UCNPs with Nd and Yb shell and GdVO4 : Yb3 ...
Computational Aerodynamics And Anatomical Characterization Of Laryngotracheal Stenosis In Children, 2018 Louisiana State University and Agricultural and Mechanical College
Computational Aerodynamics And Anatomical Characterization Of Laryngotracheal Stenosis In Children, William Poynot
LSU Master's Theses
Laryngotracheal stenosis (LTS) is a health condition in which an obstruction in the upper trachea can cause breathing difficulties and increased incidence of infection, among other symptoms. Occurring most commonly due to intubation in infants, LTS often requires corrective surgery. Currently, clinical methods of assessing the blockage region are simplistic and subjective, and it is challenging to determine the most effective surgical strategy for any given patient. In the present work, a comprehensive methodology is proposed for characterizing the stenosis region both in terms of its anatomical parameters and its corresponding aerodynamic properties. The combination of computational fluid dynamics (CFD ...
Performance Test And Numerical Simulation Of An Adjustable Implant For Treating Vocal Fold Paralysis, 2018 The University of Maine
Performance Test And Numerical Simulation Of An Adjustable Implant For Treating Vocal Fold Paralysis, Hai Zi
Electronic Theses and Dissertations
Unilateral vocal fold paralysis (UVFP) is one of the most common laryngeal diseases that affect human voice and speech production. It often causes incomplete glottal closure, resulting in voice symptoms including hoarseness, voice fatigue and increased voice effort. One common treatment of UVFP is Thyroplasty Type I, which uses a thyroplasty implant to medialize the paralyzed vocal fold and restore the normal vibration of the vocal fold. However, the surgical outcome is extremely sensitive to the size and shape of the implant. Currently, modifications in the implant size and shape rely upon surgical intuition and experience. The level of voice ...
Shaped 3d Microcarriers For Adherent Cell Culture And Analysis, 2018 University of California, Los Angeles
Shaped 3d Microcarriers For Adherent Cell Culture And Analysis, Chueh-Yu Wu, Daniel Stoecklein, Aditya Kommajosula, Jonathan Lin, Keegan Owsley, Baskar Ganapathysubramanian, Dino Di Carlo
Mechanical Engineering Publications
Standard tissue culture of adherent cells is known to poorly replicate physiology and often entails suspending cells in solution for analysis and sorting, which modulates protein expression and eliminates intercellular connections. To allow adherent culture and processing in flow, we present 3D-shaped hydrogel cell microcarriers, which are designed with a recessed nook in a first dimension to provide a tunable shear-stress shelter for cell growth, and a dumbbell shape in an orthogonal direction to allow for self-alignment in a confined flow, important for processing in flow and imaging flow cytometry. We designed a method to rapidly design, using the genetic ...
Error Estimates For Projection-Based Dynamic Augmented Lagrangian Boundary Condition Enforcement, With Application To Fluid–Structure Interaction, Yue Yu, David Kamensky, Ming-Chen Hsu, Xin Yang Lu, Yuri Bazilevs, Thomas J.R. Hughes
Mechanical Engineering Publications
In this work, we analyze the convergence of the recent numerical method for enforcing fluid–structure interaction (FSI) kinematic constraints in the immersogeometric framework for cardiovascular FSI. In the immersogeometric framework, the structure is modeled as a thin shell, and its influence on the fluid subproblem is imposed as a forcing term. This force has the interpretation of a Lagrange multiplier field supplemented by penalty forces, in an augmented Lagrangian formulation of the FSI kinematic constraints. Because of the non-matching fluid and structure discretizations used, no discrete inf-sup condition can be assumed. To avoid solving (potentially unstable) discrete saddle point ...
Bacteria Movement Near Surfaces, 2018 Purdue University
Bacteria Movement Near Surfaces, Shulin Wang, Adib Ahmadzadegan, Arezoo Ardekani
The Summer Undergraduate Research Fellowship (SURF) Symposium
Understanding the behaviors of bacteria near surfaces is crucial in many biological and ecological applications. This knowledge can be used to hinder undesired biofilm formation on medical instruments and wounds. On top of that, it could also provide further insights in biodegradation of dispersed oil. In this work, the behavior of Escherichia Coli near a surface was experimentally studied. We utilized an inverted microscope in the phase filed illumination mode and processed acquired images to track the motions of bacteria near surfaces with high accuracy and repeatability. Distribution of the cells when they reached a steady state shows that the ...
Design Of Parallel Robot For Dental Articulation And Its Optimization, 2018 University of Nebraska-Lincoln
Design Of Parallel Robot For Dental Articulation And Its Optimization, Abulimiti Delimulati
Mechanical (and Materials) Engineering -- Dissertations, Theses, and Student Research
A dental articulator is a mechanical device used to simulate the relative position and motion between the upper and lower jaw when constructing and testing dental prostheses. Typically, it can be adjusted to approximate patient-specific jaw kinematics in order to analogue the static relationship and specific motions of a patient’s mandible to maxilla. However, the use of dental articulators is essentially a trial-and-error method in order to fine-tune fit and function of a dental prosthesis. Some of the most advanced current dental articulators can reproduce the position and the motion passively; furthermore, dentists need special training for measuring patients ...
Fluorescent Nanodiamonds: Past, Present, And Future, 2018 Texas A&M University
Fluorescent Nanodiamonds: Past, Present, And Future, Masfer H. Alkahtani, Fahad Alghannam, Linkun Jiang, Abdulrahman Almethen, Arfaan A. Rampersaud, Robert Brick, Carmen L. Gomes, Marlan O. Scully, Philip R. Hemmer
Mechanical Engineering Publications
Multi-color fluorescent nanodiamonds (FNDs) containing a variety of color centers are promising fluorescent markers for biomedical applications. Compared to colloidal quantum dots and organic dyes, FNDs have the advantage of lower toxicity, exceptional chemical stability, and better photostability. They can be surface functionalized by techniques similar to those used for other nanoparticles. They exhibit a variety of emission wavelengths from visible to near infrared, with narrow or broad bandwidths depending on their color centers. In addition, some color centers can detect changes in magnetic fields, electric fields, and temperature. In this article review, we will discuss the current trends in ...
A Composite Material-Based Computational Model For Diaphragm Muscle Biomechanical Simulation, 2018 The University of Western Ontario
A Composite Material-Based Computational Model For Diaphragm Muscle Biomechanical Simulation, Brett Coelho
Electronic Thesis and Dissertation Repository
Lung cancer is the most common cause of cancer related death among both men and women. Radiation therapy is the most widely used treatment for this disease. Motion compensation for tumor movement is often clinically important and biomechanics-based motion models may provide the most robust method as they are based on the physics of motion. In this study, we aim to develop a patient specific biomechanical model that predicts the deformation field of the diaphragm muscle during respiration. The first part of the project involved developing an accurate and adaptable micro-to-macro mechanical approach for skeletal muscle tissue modelling for application ...
Agonabadietal_2018_Eduexoemgdelaytutorial_13.Pdf, 2018 University of Nebraska at Omaha
Agonabadietal_2018_Eduexoemgdelaytutorial_13.Pdf, Arash Mohammadzadeh Gonabadi, Philippe Malcolm
No abstract provided.
Experimental, Analytical, And Numerical Evaluation Of The Mechanical Properties Of The Brain Tissue, 2018 Louisiana State University and Agricultural and Mechanical College
Experimental, Analytical, And Numerical Evaluation Of The Mechanical Properties Of The Brain Tissue, Aref Samadidooki
LSU Doctoral Dissertations
A true understanding of the mechanisms behind most of the brain diseases is still out of reach. For several years, the interest of scientists has been focused on the genetic and biological causes, however, recent studies unraveled the importance of the biomechanics of the brain growth, folding, impact resistance, and deformation on its pathological conditions. While, a wide range of different methods have been used for characterization of the mechanical properties of the brain at the tissue level, the obtained results from different studies are extremely scattered and sometimes in contrast to one another. Since the brain tissue is extremely ...
An In-Silico Assessment Of Stemless Shoulder Arthroplasty: From Ct To Predicted Bone Response, 2018 The University of Western Ontario
An In-Silico Assessment Of Stemless Shoulder Arthroplasty: From Ct To Predicted Bone Response, Jacob M. Reeves
Electronic Thesis and Dissertation Repository
Despite the emergence of stemless humeral implants that utilize short fixation features to gain purchase solely in the metaphysis, the literature contains little information regardingthe morphology and mechanical properties of the humerus’ proximal trabecular-canal, and how stemless implants impact bone response. The present work employs in-silicotools, including CT-based and Finite Element (FE) methods, to define parameters that may influence stemless implant design.
The density and morphology of the proximal humerus were assessed using CT-derived point clouds of the trabecular-canal. Bone density was found to diminish 15-20mm beneath the humeral head resection and was greater peripherally. The depth, path and bounding ...
Design Of A Robotic Cownose Ray, 2018 Union College
Design Of A Robotic Cownose Ray, Mark Marzotto
Nature often inspires advances in science and technology and a promising example of this is mimicking locomotion of underwater animals. The main ways in which manmade aquatic vehicles propel themselves are water jets and propellers, which are inconsistent with how underwater animals swim. The cownose ray displays very efficient thrust with low frequency strokes by using a combination of oscillations and undulations with its pectoral fins. The goal of this paper is to mechanically replicate the actual fin motion of the cownose ray in order to capture these attractive features. The design will account for both the oscillations by designing ...
Fixing Vertebral Compression Fractures With Medtronic, 2018 California Polytechnic State University, San Luis Obispo
Fixing Vertebral Compression Fractures With Medtronic, Kelly Fitzgerald, Trevor Bingham, Alex Denbaugh, Jordan Tang, Jon Stearns
Industrial and Manufacturing Engineering
No abstract provided.
Team Joseph's Bike Trailer, 2018 California Polytechnic State University, San Luis Obispo
Team Joseph's Bike Trailer, Keely Thompson, Curtis Wathne, Ryan Meinhardt
This final design report shows the results of this senior project’s design process of creating a custom bike trailer for Team Joseph. As done in the Scope of Work, Preliminary Design report, and Critical Design report, current products, relevant technologies, and American Society for Testing and Materials (ASTM) standards are fully researched and benchmarked to aid in the design selection process. Customer requirements are looked at and developed into engineering specifications. A detailed design was created for CDR to show to Team Joseph, and manufacturing and testing plans were laid out. This final design report adds the final design ...
Curb Navigation, 2018 California Polytechnic State University, San Luis Obispo
Curb Navigation, Cole A. Tudor, Kaitlyn R. Adams, Robbie Huerta
The Curb Navigation senior project, proposed by the QL+ organization, was presented to find a solution to an issue a former veteran, Velette, is having. Velette has a difficult time maneuvering curbs when out doing day-to-day errands and activities. The goal of this project is to develop a solution that will give Velette the ability to traverse curbs without the assistance of others or the need to do a wheelie that can lead to an injury. The team has found that adapting and optimizing an anti-tipper design may be the best way to solve the proposed challenge. The team decided ...
Human Knee Fea Model For Transtibial Amputee Tibial Cartilage Pressure In Gait And Cycling, 2018 California Polytechnic State University, San Luis Obispo
Human Knee Fea Model For Transtibial Amputee Tibial Cartilage Pressure In Gait And Cycling, Gregory Lane
Master's Theses and Project Reports
Osteoarthritis (OA) is a debilitating disease affecting roughly 31 million Americans. The incidence of OA is significantly higher for persons who have suffered a transtibial amputation. Abnormal cartilage stress can cause higher OA risk, however it is unknown if there is a connection between exercise type and cartilage stress. To help answer this, a tibiofemoral FEA model was created. Utilizing linear elastic isotropic materials and non-linear springs, the model was validated to experimental cadaveric data. In a previous study, 6 control and 6 amputee subjects underwent gait and cycling experiments. The resultant knee loads were analyzed to find the maximum ...