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Shaped 3d Microcarriers For Adherent Cell Culture And Analysis, Chueh-Yu Wu, Daniel Stoecklein, Aditya Kommajosula, Jonathan Lin, Keegan Owsley, Baskar Ganapathysubramanian, Dino Di Carlo 2018 University of California, Los Angeles

Shaped 3d Microcarriers For Adherent Cell Culture And Analysis, Chueh-Yu Wu, Daniel Stoecklein, Aditya Kommajosula, Jonathan Lin, Keegan Owsley, Baskar Ganapathysubramanian, Dino Di Carlo

Mechanical Engineering Publications

Standard tissue culture of adherent cells is known to poorly replicate physiology and often entails suspending cells in solution for analysis and sorting, which modulates protein expression and eliminates intercellular connections. To allow adherent culture and processing in flow, we present 3D-shaped hydrogel cell microcarriers, which are designed with a recessed nook in a first dimension to provide a tunable shear-stress shelter for cell growth, and a dumbbell shape in an orthogonal direction to allow for self-alignment in a confined flow, important for processing in flow and imaging flow cytometry. We designed a method to rapidly design, using the genetic ...


Bacteria Movement Near Surfaces, Shulin Wang, Adib Ahmadzadegan, Arezoo Ardekani 2018 Purdue University

Bacteria Movement Near Surfaces, Shulin Wang, Adib Ahmadzadegan, Arezoo Ardekani

The Summer Undergraduate Research Fellowship (SURF) Symposium

Understanding the behaviors of bacteria near surfaces is crucial in many biological and ecological applications. This knowledge can be used to hinder undesired biofilm formation on medical instruments and wounds. On top of that, it could also provide further insights in biodegradation of dispersed oil. In this work, the behavior of Escherichia Coli near a surface was experimentally studied. We utilized an inverted microscope in the phase filed illumination mode and processed acquired images to track the motions of bacteria near surfaces with high accuracy and repeatability. Distribution of the cells when they reached a steady state shows that the ...


Design Of Parallel Robot For Dental Articulation And Its Optimization, Abulimiti Delimulati 2018 University of Nebraska-Lincoln

Design Of Parallel Robot For Dental Articulation And Its Optimization, Abulimiti Delimulati

Mechanical (and Materials) Engineering -- Dissertations, Theses, and Student Research

A dental articulator is a mechanical device used to simulate the relative position and motion between the upper and lower jaw when constructing and testing dental prostheses. Typically, it can be adjusted to approximate patient-specific jaw kinematics in order to analogue the static relationship and specific motions of a patient’s mandible to maxilla. However, the use of dental articulators is essentially a trial-and-error method in order to fine-tune fit and function of a dental prosthesis. Some of the most advanced current dental articulators can reproduce the position and the motion passively; furthermore, dentists need special training for measuring patients ...


Fluorescent Nanodiamonds: Past, Present, And Future, Masfer H. Alkahtani, Fahad Alghannam, Linkun Jiang, Abdulrahman Almethen, Arfaan A. Rampersaud, Robert Brick, Carmen L. Gomes, Marlan O. Scully, Philip R. Hemmer 2018 Texas A&M University

Fluorescent Nanodiamonds: Past, Present, And Future, Masfer H. Alkahtani, Fahad Alghannam, Linkun Jiang, Abdulrahman Almethen, Arfaan A. Rampersaud, Robert Brick, Carmen L. Gomes, Marlan O. Scully, Philip R. Hemmer

Mechanical Engineering Publications

Multi-color fluorescent nanodiamonds (FNDs) containing a variety of color centers are promising fluorescent markers for biomedical applications. Compared to colloidal quantum dots and organic dyes, FNDs have the advantage of lower toxicity, exceptional chemical stability, and better photostability. They can be surface functionalized by techniques similar to those used for other nanoparticles. They exhibit a variety of emission wavelengths from visible to near infrared, with narrow or broad bandwidths depending on their color centers. In addition, some color centers can detect changes in magnetic fields, electric fields, and temperature. In this article review, we will discuss the current trends in ...


Agonabadietal_2018_Eduexoemgdelaytutorial_13.Pdf, Arash Mohammadzadeh Gonabadi, Philippe Malcolm 2018 University of Nebraska at Omaha

Agonabadietal_2018_Eduexoemgdelaytutorial_13.Pdf, Arash Mohammadzadeh Gonabadi, Philippe Malcolm

Philippe Malcolm

No abstract provided.


Experimental, Analytical, And Numerical Evaluation Of The Mechanical Properties Of The Brain Tissue, Aref Samadidooki 2018 Louisiana State University and Agricultural and Mechanical College

Experimental, Analytical, And Numerical Evaluation Of The Mechanical Properties Of The Brain Tissue, Aref Samadidooki

LSU Doctoral Dissertations

A true understanding of the mechanisms behind most of the brain diseases is still out of reach. For several years, the interest of scientists has been focused on the genetic and biological causes, however, recent studies unraveled the importance of the biomechanics of the brain growth, folding, impact resistance, and deformation on its pathological conditions. While, a wide range of different methods have been used for characterization of the mechanical properties of the brain at the tissue level, the obtained results from different studies are extremely scattered and sometimes in contrast to one another. Since the brain tissue is extremely ...


An In-Silico Assessment Of Stemless Shoulder Arthroplasty: From Ct To Predicted Bone Response, Jacob M. Reeves 2018 The University of Western Ontario

An In-Silico Assessment Of Stemless Shoulder Arthroplasty: From Ct To Predicted Bone Response, Jacob M. Reeves

Electronic Thesis and Dissertation Repository

Despite the emergence of stemless humeral implants that utilize short fixation features to gain purchase solely in the metaphysis, the literature contains little information regardingthe morphology and mechanical properties of the humerus’ proximal trabecular-canal, and how stemless implants impact bone response. The present work employs in-silicotools, including CT-based and Finite Element (FE) methods, to define parameters that may influence stemless implant design.

The density and morphology of the proximal humerus were assessed using CT-derived point clouds of the trabecular-canal. Bone density was found to diminish 15-20mm beneath the humeral head resection and was greater peripherally. The depth, path and bounding ...


Fixing Vertebral Compression Fractures With Medtronic, Kelly Fitzgerald, Trevor Bingham, Alex Denbaugh, Jordan Tang, Jon Stearns 2018 California Polytechnic State University, San Luis Obispo

Fixing Vertebral Compression Fractures With Medtronic, Kelly Fitzgerald, Trevor Bingham, Alex Denbaugh, Jordan Tang, Jon Stearns

Industrial and Manufacturing Engineering

No abstract provided.


Team Joseph's Bike Trailer, Keely Thompson, Curtis Wathne, Ryan Meinhardt 2018 California Polytechnic State University, San Luis Obispo

Team Joseph's Bike Trailer, Keely Thompson, Curtis Wathne, Ryan Meinhardt

Mechanical Engineering

This final design report shows the results of this senior project’s design process of creating a custom bike trailer for Team Joseph. As done in the Scope of Work, Preliminary Design report, and Critical Design report, current products, relevant technologies, and American Society for Testing and Materials (ASTM) standards are fully researched and benchmarked to aid in the design selection process. Customer requirements are looked at and developed into engineering specifications. A detailed design was created for CDR to show to Team Joseph, and manufacturing and testing plans were laid out. This final design report adds the final design ...


Curb Navigation, Cole A. Tudor, Kaitlyn R. Adams, Robbie Huerta 2018 California Polytechnic State University, San Luis Obispo

Curb Navigation, Cole A. Tudor, Kaitlyn R. Adams, Robbie Huerta

Mechanical Engineering

The Curb Navigation senior project, proposed by the QL+ organization, was presented to find a solution to an issue a former veteran, Velette, is having. Velette has a difficult time maneuvering curbs when out doing day-to-day errands and activities. The goal of this project is to develop a solution that will give Velette the ability to traverse curbs without the assistance of others or the need to do a wheelie that can lead to an injury. The team has found that adapting and optimizing an anti-tipper design may be the best way to solve the proposed challenge. The team decided ...


Human Knee Fea Model For Transtibial Amputee Tibial Cartilage Pressure In Gait And Cycling, Gregory Lane 2018 California Polytechnic State University, San Luis Obispo

Human Knee Fea Model For Transtibial Amputee Tibial Cartilage Pressure In Gait And Cycling, Gregory Lane

Master's Theses and Project Reports

Osteoarthritis (OA) is a debilitating disease affecting roughly 31 million Americans. The incidence of OA is significantly higher for persons who have suffered a transtibial amputation. Abnormal cartilage stress can cause higher OA risk, however it is unknown if there is a connection between exercise type and cartilage stress. To help answer this, a tibiofemoral FEA model was created. Utilizing linear elastic isotropic materials and non-linear springs, the model was validated to experimental cadaveric data. In a previous study, 6 control and 6 amputee subjects underwent gait and cycling experiments. The resultant knee loads were analyzed to find the maximum ...


Design Of A Robotic Cownose Ray, Mark Marzotto 2018 Union College

Design Of A Robotic Cownose Ray, Mark Marzotto

Honors Theses

Nature often inspires advances in science and technology and a promising example of this is mimicking locomotion of underwater animals. The main ways in which manmade aquatic vehicles propel themselves are water jets and propellers, which are inconsistent with how underwater animals swim. The cownose ray displays very efficient thrust with low frequency strokes by using a combination of oscillations and undulations with its pectoral fins. The goal of this paper is to mechanically replicate the actual fin motion of the cownose ray in order to capture these attractive features. The design will account for both the oscillations by designing ...


Blunt And Ballistic Impacts On Human Head Models: An Analytical And Numerical Study, Yongqiang Li 2018 Mechanical Engineering

Blunt And Ballistic Impacts On Human Head Models: An Analytical And Numerical Study, Yongqiang Li

Mechanical Engineering Research Theses and Dissertations

Head injuries, as a leading cause of death, have become a major health care issue for civilians and soldiers. There has been an urgent need to understand mechanisms of such injuries. The objective of this dissertation research is to study some head injuries and related mechanisms using analytical and computational models.

In Chapter 2, a new analytical (non-linear) model for the impact of a solid sphere on a fluid-filled spherical shell is developed by including the stress wave propagation effect in addition to the Hertzian contact deformations and the shell membrane and bending actions. A simplified (linearized) model incorporating the ...


Soft-Microrobotics: The Manipulation Of Alginate Artificial Cells, Samuel Sheckman 2018 Southern Methodist University

Soft-Microrobotics: The Manipulation Of Alginate Artificial Cells, Samuel Sheckman

Mechanical Engineering Research Theses and Dissertations

In this work, the approach to the manipulation of alginate artificial cell soft-microrobots, both individually and in swarms is shown. Fabrication of these artificial cells were completed through centrifugation, producing large volumes of artificial cells, encapsulated with superparamagnetic iron oxide nanoparticles; these artificial cells can be then externally stimulated by an applied magnetic field. The construction of a Permeant Magnet Stage (PMS) was produced to manipulate the artificial cells individually and in swarms. The stage functionalizes the permanent magnet in the 2D xy-plane. Once the PMS was completed, Parallel self-assembly (Object Particle Computation) using swarms of artificial cells in complex ...


Modeling Of Swimming Cells From Nano-Scale To Micro-Scale, Yicheng Zhao 2018 Washinton University in St. Louis

Modeling Of Swimming Cells From Nano-Scale To Micro-Scale, Yicheng Zhao

Engineering and Applied Science Theses & Dissertations

Certain human genetic diseases -- primary ciliary dyskinesia, infertility, and hydrocephalus -- are characterized by changes in beat frequency and waveform of cilia and flagella. Chlamydomonas reinhardtii, which is a single-cell green alga about ten micrometers in diameter that swims with two flagella, serves as an excellent biological model because its flagella share the same structure and genetic background as mammalian cilia and flagella. This study uses the finite element method to investigate the behavior of C. reinhardtii swimming from nano-scale to micro-scale. At the device-level, micro-scale modeling indicates that well-designed acoustic microfluidic devices can be used to trap groups of C ...


Effects Of Hydration And Mineralization On The Mechanical Behavior Of Collagen Fibrils, Marco Fielder 2018 University of Arkansas, Fayetteville

Effects Of Hydration And Mineralization On The Mechanical Behavior Of Collagen Fibrils, Marco Fielder

Theses and Dissertations

Bone is a composite biomaterial with a structural load-bearing function. Understanding the biomechanics of bone is important for characterizing factors such as age, trauma, or disease, and in the development of scaffolds for tissue engineering and bioinspired materials. At the nanoscale, bone is primarily composed of collagen protein, apatite crystals, and water. Though several studies have characterized nanoscale bone mechanics as the mineral content changes, the effect of water, mineral, and carbon nanotube (CNT) content and distribution in fibril gap and overlap regions is unexplored. This study used molecular dynamics to investigate the change in collagen fibril deformation mechanisms as ...


A Numerical Investigation Of Bio-Inspired Scaffolds And Surface Textures, Yucong Gu 2018 University of Arkansas, Fayetteville

A Numerical Investigation Of Bio-Inspired Scaffolds And Surface Textures, Yucong Gu

Theses and Dissertations

Synthetic scaffolds are widely used as implants to repair bone fracture. Without a proper design, scaffolds could pose significant health risks to the patient and fail to heal the bone properly. A good synthetic scaffold needs to have high porosity and large pore size to allow new bone cells to form on it. However, a scaffold with higher porosity and larger pore size tends to have reduced mechanical strength. Thus, it is important to find a structural design which allows the implant to have a high porosity and large pore size while retaining high strength. In this research, a 3D-printable ...


Laser Scribed Graphene Biosensor For Detection Of Biogenic Amines In Food Samples Using Locally Sourced Materials, Diana C. Vanegas, Laksmi Patiño, Connie Mendez, Daniela Alves de Oliveira, Alba M. Torres, Carmen Gomes, Eric S. McLamore 2018 Universidad del Valle, Cali

Laser Scribed Graphene Biosensor For Detection Of Biogenic Amines In Food Samples Using Locally Sourced Materials, Diana C. Vanegas, Laksmi Patiño, Connie Mendez, Daniela Alves De Oliveira, Alba M. Torres, Carmen Gomes, Eric S. Mclamore

Mechanical Engineering Publications

In foods, high levels of biogenic amines (BA) are the result of microbial metabolism that could be affected by temperatures and storage conditions. Thus, the level of BA is commonly used as an indicator of food safety and quality. This manuscript outlines the development of laser scribed graphene electrodes, with locally sourced materials, for reagent-free food safety biosensing. To fabricate the biosensors, the graphene surface was functionalized with copper microparticles and diamine oxidase, purchased from a local supermarket; and then compared to biosensors fabricated with analytical grade materials. The amperometric biosensor exhibits good electrochemical performance, with an average histamine sensitivity ...


A Numerical Investigation Of Human Cough Jet Development And Droplet Dispersion, Ran Bi 2018 The University of Western Ontario

A Numerical Investigation Of Human Cough Jet Development And Droplet Dispersion, Ran Bi

Electronic Thesis and Dissertation Repository

As part of the Western Cold and Flu aerosol (WeCoF) studies, the present study provides Computational Fluid Dynamics (CFD) modelling of human cough flow. The cough flow is characterized in two different aspects, the flow field and the droplets. In the study of the flow field of coughing, various dynamic characteristics, including the velocity variation, streamwise penetration and power spectral density, are examined. CFD simulations using two different approaches, the unsteady Reynolds Averaged Navier-Stokes (URANS) and the large eddy simulation (LES), are performed for comparison purposes. The numerical results are validated by the experimental data obtained from the measurements by ...


Effect Of Shot Peening On Stress Corrosion Behavior Of Biodegradable Magnesium We43, Tejaswita Patil 2018 University of Nebraska - Lincoln

Effect Of Shot Peening On Stress Corrosion Behavior Of Biodegradable Magnesium We43, Tejaswita Patil

Mechanical (and Materials) Engineering -- Dissertations, Theses, and Student Research

Conventionally used metals for orthopedic devices made of titanium, stainless steel, and Co-Cr alloys are designed to be permanently implanted. However, long-term complications arise and a secondary implant removal surgery is often necessary. A mismatch in stiffness between the bone and implant results in stress shielding that negatively affects bone density. To overcome these problems, magnesium alloys (e.g., WE34) are favored due to a lower Young’s modulus (45 GPa) and biodegradability. The critical technical barrier with magnesium alloys is their high corrosion rate in physiological (salt-based) environments. One solution is to use surface treatments, such as shot peening ...


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