Mechanical Reliability Of Implantable Polyimide-Based Magnetic Microactuators For Biofouling Removal, 2016 University of Puerto Rico, Mayaguez
Mechanical Reliability Of Implantable Polyimide-Based Magnetic Microactuators For Biofouling Removal, Christian G. Figueroa-Espada, Qi Yang, Hyowon Lee
The Summer Undergraduate Research Fellowship (SURF) Symposium
Hydrocephalus is a neurological disorder that typically requires a long-term implantation of a shunt system to manage its symptoms. These shunt systems are notorious for their extremely high failure rate. More than 40% of all implanted shunt systems fail within the first year of implantation. On average, 85% of all hydrocephalus patients with shunt systems undergo at least two shunt-revision surgeries within 10 years of implantation. A large portion of this high failure rate can be attributed to biofouling-related obstructions and infections. Previously, we developed flexible polyimide-based magnetic microactuators to remove obstructions formed on hydrocephalus shunts. To test the long-term ...
Movement And Distribution Of Bacteria Near Surfaces, 2016 Purdue University
Movement And Distribution Of Bacteria Near Surfaces, Daniel A. Quinkert, Adib Ahmadzadegan, Arezoo M. Ardekani
The Summer Undergraduate Research Fellowship (SURF) Symposium
Bacteria are found everywhere in nature, including within human/animal bodies, biomedical devices, industrial equipment, oceans and lakes. They can be found in planktonic state within a bulk liquid phase or attached to surfaces with the potential to form biofilms. In this study we are interested in the movement and distribution of bacteria near surfaces. The concentrations and fluid interactions of bacteria were characterized at various distances from a surface. Psuedomonas putida F1 was observed in a suspension near a surface. Bacteria movements were visualized with an inverted microscope at 40x magnification. P. putida F1 exhibited greater density in close ...
Microfluidic Platform For Impedance Characterization Of Endothelial Cells Under Fluid Shear Stress., 2016 University of Louisville
Microfluidic Platform For Impedance Characterization Of Endothelial Cells Under Fluid Shear Stress., Vanessa Velasco
Electronic Theses and Dissertations
Endothelium dysfunction has been associated with many pathophysiological processes leading to cardiovascular diseases. Studying endothelium behavior is vital to understand the onset, prevention, and treatment of such diseases. Electrical impedance spectroscopy has been shown to provide a real-time in vitro evaluation of cell behavior including cell monolayer permeability. However, the majority of published work has been primarily with static cell culture models or macro-scale models that do not properly represent the physiological sizes, structures, and environmental conditions of human blood vessels. Within this dissertation, the design, fabrication, characterization, and application of a microfluidic impedance platform is presented for the in ...
Strain Energy Absorption Corresponds To Decreased Incidence Of Ventricular Fibrillation In A Commotio Cordis Model, Kayt E. Frisch, Mark S. Link, John Van Weelden
Faculty Work: Comprehensive List
A healthy teenage boy is playing high school baseball, when he is struck in the chest by the ball; minutes later, his heart is experiencing ventricular fibrillation (VF) and the only way to resuscitate him is to use a defibrillator. This phenomenon, is known as Commotio Cordis (CC), and occurs as many as 20 times each year in the United States. CC most frequently occurs in sports with small balls (e.g. baseball or lacrosse) and requires a specific set of circumstances–a projectile with a certain amount of energy that impacts directly over the left ventricle of the heart ...
Developing Predictive Models For Upper Extremity Post–Stroke Motion Quality Estimation Using Decision Trees And Bagging Forest, 2016 University of Tennessee, Knoxville
Developing Predictive Models For Upper Extremity Post–Stroke Motion Quality Estimation Using Decision Trees And Bagging Forest, Sarvenaz Chaeibakhsh
Stroke is one of the leading causes of long–term disability. Approximately twothirds of stroke survivors require long-term rehabilitation, which suggests the importance of understanding the post-stroke recovery process during his activities of daily living. This problem is formulated as quantifying and estimating the poststroke movement quality in real world settings. To address this need, we have developed an approach that quantifies physical activities and can evaluate the performance quality. Wearable accelerometer and gyroscope are used to measure the upper extremity motions and to develop a mathematical framework to objectively relates sensors’ data to clinical performance indices. In this article ...
Low-Cost Prosthetic Transfemoral Socket, 2016 California Polytechnic State University, San Luis Obispo
Low-Cost Prosthetic Transfemoral Socket, Emelie Deans, Joshua Ledgerwood, Leah Moore, Shaina Jung, Kristen Temnyk
The goal of this senior project was to design and fabricate a low-cost adjustable prosthetic socket for above the knee amputees. This low-cost consideration was incorporated with the original intent to be used in Fiji, however, this changed to the Dominican Republic. It became clear that the need for an adjustable socket was more as a transitional socket. This transitional socket would be used for the first 6 -12 months upon amputation because this when the most amount of volume fluctuation occurs. The project sponsor, LIM Innovations, has already designed the Infinite Socket which contains four main functioning parts: baseplate ...
Non-Puncturing, No Slip Thv Leaflet Gripper, 2016 California Polytechnic State University, San Luis Obispo
Non-Puncturing, No Slip Thv Leaflet Gripper, Brooks Kelly, Eric Nagaoka, Johnny Phane
Biomimetic Seal Flipper Test Rig, 2016 California Polytechnic State University, San Luis Obispo
Biomimetic Seal Flipper Test Rig, Gordon D. Belyea, Laura Kawashiri, Dylan Rinker, Kurt Beske
No abstract provided.
Prosthetic Socket Cooling System, 2016 California Polytechnic State University – San Luis Obispo
Prosthetic Socket Cooling System, Benjamin K. Kraw, Kathy Ha, Derek Piastrelli, Cuong Lai
A team of four senior-level undergraduate students in the Interdisciplinary Senior Project Design course in the Engineering Department of California Polytechnic State University: San Luis Obispo have worked to develop a prosthetic socket cooling system, namely for veteran Taylor Morris and exclusively for a transfemoral prosthetic socket, under the Quality of Life+ Laboratory. This cooling system will utilize the thermoelectric effect known as the Peltier effect to transmit heat generated from the residual limb to the surrounding environment by means of forced convection over small aluminum heat sinks. Two measurement devices have also been developed to, one, measure the heat ...
The Effects Of Obesity On Resultant Knee Joint Loads For Gait And Cycling, 2016 California Polytechnic State University, San Luis Obispo
The Effects Of Obesity On Resultant Knee Joint Loads For Gait And Cycling, Juan Gutierrez-Franco
Master's Theses and Project Reports
Osteoarthritis (OA) is a degenerative disease of cartilage and bone tissue and the most common form of arthritis, accounting for US$ 10.5 billion in hospital charges in 2006. Obesity (OB) has been linked to increased risk of developing knee OA due to increased knee joint loads and varus-valgus misalignment. Walking is recommended as a weight-loss activity but it may increase risk of knee OA as OB gait increases knee loads. Cycling has been proposed as an alternative weight-loss measure, however, lack of studies comparing normal weight (NW) and OB subjects in cycling and gait hinder identification of exercises that ...
Numerical Modeling Of Fluid-Porous Structure Interaction In Arteries, 2016 University of Pittsburgh - Main Campus
Numerical Modeling Of Fluid-Porous Structure Interaction In Arteries, Rana Zakerzadeh, Paolo Zunino
Biology and Medicine Through Mathematics Conference
No abstract provided.
A Reduced Order Model For Efficient Physiological Flow Analysis In Aneurysms By Proper Orthogonal Decomposition, 2016 University of Massachusetts Amherst
A Reduced Order Model For Efficient Physiological Flow Analysis In Aneurysms By Proper Orthogonal Decomposition, Gary Han Chang, Yahya Modarres-Sadeghi
UMass Center for Clinical and Translational Science Research Retreat
Simulating physiological flows using computational fluid dynamics (CFD) remains to be computationally expensive and difficult for clinical usage because of the physiological flow and geometrical complexity involved in patient specific situations. We use the reduced order modeling (ROM) of such systems with high nonlinearity and geometrical non-uniformity to replace the full, nonlinear model with a low-degrees of freedom ROM model. We construct ROM models by the proper orthogonal decomposition (POD) method to estimate the flow-induced wall shear stress (WSS) and pressure loading of a simplified abdominal aortic aneurysm and a bifurcation cerebral aneurysm. This method allows us to investigate a ...
Walking Simulator Mechanism, 2016 Cleveland State University
Walking Simulator Mechanism, Titus Lungu, Igor Tachynskyy, Omri Tayyara
The Downtown Review
This paper presents the design, simulation, and kinematic evaluation of a mechanism aimed at simulating both the motion and ground reaction forces produced by a human foot while walking. Such a mechanism can be used to test the durability of shoes through life cycle analysis. In attempting to mimic the physical motion of the human foot as closely as possible, the forces experienced by the human foot were also accurately replicated through the incorporation of a non-stationary testing platform. As is shown in the paper, this testing environment allows for simple adjustments to be made in order to simulate different ...
Mild Traumatic Brain Injury: Combined In Silico And In Vitro Studies, 2016 University of Nebraska-Lincoln
Mild Traumatic Brain Injury: Combined In Silico And In Vitro Studies, Yi Hua
Mechanical (and Materials) Engineering -- Dissertations, Theses, and Student Research
Mild traumatic brain injury (TBI) is a significant public health concern worldwide and has attracted significant attention due to high-impact sport as well as improvised explosive devices used in military conflicts. The earliest sign of mild TBI is associated with cognitive, behavioral and physical/somatic changes, which are commonly invisible to existing medical techniques. Thus it is essential to target mechanisms of mild TBI and its associated damage measures for earlier diagnosis/treatment and enhanced protection strategies.
In this work, the mechanism of blast-induced mild TBI was inspected through integrated in silico and in vitro models. A three-dimensional (3D) human ...
Portable High Throughput Digital Microfluidics And On-Chip Bacteria Cultures, 2016 University of Nevada, Las Vegas
Portable High Throughput Digital Microfluidics And On-Chip Bacteria Cultures, Yiyan Li
UNLV Theses, Dissertations, Professional Papers, and Capstones
An intelligent, portable, and high throughput digital microfluidic (DMF) system is developed. Chapter 1 introduces microfluidics and DMF systems. In Chapter 2, a low-cost and high resolution capacitive-to-digital converter integrated circuit is used for droplet position detection. A field-programmable gate array FPGA is used as the integrated logic hub of the system for highly reliable and efficient control of the circuit. In this chapter a fast-fabricating PCB (printed circuit board) substrate microfluidic system is proposed. Smaller actuation threshold voltages than those previously reported are obtained. Droplets (3 µL) are actuated using 200 V, 500 Hz DC pulses. Droplet positions can ...
Atomic Force Microscopy Based Dna Analysis, 2016 University of Arkansas, Fayetteville
Atomic Force Microscopy Based Dna Analysis, Drew Creighton
Mechanical Engineering Undergraduate Honors Theses
This report explores dry and wet scanning of a surface and DNA pickup using an AFM, as well as fluorescent staining of DNA. Dry and wet scans of DNA were obtained using a cantilever AFM tip in tapping mode. Dry scans were found to be clearer than wet scans; however, the drying process was found to decrease the thickness of DNA 2–4 times less than its original thickness. Alternately, wet scans were found to be less clear than dry scans and introduced more noise into the images obtained. Additionally, DNA kept its initial thickness during wet scanning. DNA was ...
Spinal Implant Design And Subsidence, 2016 Cedarville University
Spinal Implant Design And Subsidence, Schuyler E. Price, Lorrin Schoeneweis, Hannah Steele, Matthew Shomper, Timothy L. Norman
The Research and Scholarship Symposium
A spinal implant may be used in people who have diseased or injured intervertebral discs pushing against their spinal cord and nerves, causing them loss of sensation due to nerve impingement. Patients who have not found relief through non-surgical means may require a discectomy, which removes the disc and relieves the pressure. There are several ways to then fill the resulting gap which include fusion devices, artificial disc replacement (ADR) devices, or bone grafts. Our study focused on the first two mechanical options.
Subsidence, or the vertical movement of the device into the adjacent vertebral bodies, is an often reported ...
A Retrospective Study Of Amusement Ride Restraint And Containment Systems: Identifying Design Challenges For Statistically Rare Anthropometric Cases, Paula M. Stenzler
Engineering Management & Systems Engineering Theses & Dissertations
The intent of this project was to conduct a retrospective study of amusement ride restraint and containment systems’ failures to identify the challenges associated with existing design criteria to safely accommodate statistically rare groups that fall outside amusement industry standards. Innovations in ride technology provide an opportunity for injuries to occur if restraint and containment systems cannot properly accommodate unique patron anthropometry. It is paramount to understand how anthropometric features contribute to the patron’s ability to defeat ride restraint and containment systems. A systemic perspective was used based on industry accident data to frame the problem associated with restraint ...
Optimizing The Rehabilitation Of Elbow Lateral Collateral Ligament Injuries, 2016 The University of Western Ontario
Optimizing The Rehabilitation Of Elbow Lateral Collateral Ligament Injuries, Ranita Harpreet Kaur Manocha
Electronic Thesis and Dissertation Repository
Elbow lateral collateral ligament (LCL) injuries frequently arise following trauma, and can result in disabling instability. Typically such injuries are managed with immobilization followed by a graduated exercise regime; however there is minimal biomechanical evidence to support current treatment protocols. This investigation examines the in vitro effectiveness of several rehabilitation techniques using a custom elbow motion simulator. It was found that active range of motion is safest in the overhead position (n = 7). Early motion in this position may reduce the incidence of elbow stiffness without compromising ligament healing following LCL injury. Forearm pronation and active motion stabilize the LCL-deficient ...
Design And Analysis Of A Lift Assist Walker, 2016 California Polytechnic State University – San Luis Obispo
Design And Analysis Of A Lift Assist Walker, Deep P. Shah
Master's Theses and Project Reports
Walkers provided stability to the elderly but cannot assist a person from sitting to standing. The objective of this project is to present the design and analysis of a lift assist walker. This report discusses the design and analysis of a collapsible lift assist walker capable of lifting a patient up to 250 lbs. from seated to standing in under 10 seconds. The designed walker utilized a two stage scissor mechanism with a gas spring assisted embedded linear actuator.