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Comparative Deformability Characterization On Hiv Variants Using A Solid State Nanopore, Bin Peng 2018 Southern Methodist University

Comparative Deformability Characterization On Hiv Variants Using A Solid State Nanopore, Bin Peng

Mechanical Engineering Research Theses and Dissertations

Nanoscale lipid vesicles, such as enveloped viruses, lysosomes and exosomes, play a significant role in material transport in biological systems. Membrane deformation of these naturally occurring nanocarriers is a defining factor in maintaining their functionality. De- spite the great significance to biologists and biophysicists, experimental investigations into membrane deformablity are currently lacking due to technical challenges of studying mem- brane deformation especially at the sub-micron scale. Optical microscopy lacks sufficient resolution to capture deformation at the nanoscale. Other techniques, such as atomic force microscopy, require laborious procedures and are intrinsically low-throughput. In this paper, we report a new technique based ...


Laser Scribed Graphene Biosensor For Detection Of Biogenic Amines In Food Samples Using Locally Sourced Materials, Diana C. Vanegas, Laksmi Patiño, Connie Mendez, Daniela Alves de Oliveira, Alba M. Torres, Carmen Gomes, Eric S. McLamore 2018 Universidad del Valle, Cali

Laser Scribed Graphene Biosensor For Detection Of Biogenic Amines In Food Samples Using Locally Sourced Materials, Diana C. Vanegas, Laksmi Patiño, Connie Mendez, Daniela Alves De Oliveira, Alba M. Torres, Carmen Gomes, Eric S. Mclamore

Mechanical Engineering Publications

In foods, high levels of biogenic amines (BA) are the result of microbial metabolism that could be affected by temperatures and storage conditions. Thus, the level of BA is commonly used as an indicator of food safety and quality. This manuscript outlines the development of laser scribed graphene electrodes, with locally sourced materials, for reagent-free food safety biosensing. To fabricate the biosensors, the graphene surface was functionalized with copper microparticles and diamine oxidase, purchased from a local supermarket; and then compared to biosensors fabricated with analytical grade materials. The amperometric biosensor exhibits good electrochemical performance, with an average histamine sensitivity ...


A Numerical Investigation Of Human Cough Jet Development And Droplet Dispersion, Ran Bi 2018 The University of Western Ontario

A Numerical Investigation Of Human Cough Jet Development And Droplet Dispersion, Ran Bi

Electronic Thesis and Dissertation Repository

As part of the Western Cold and Flu aerosol (WeCoF) studies, the present study provides Computational Fluid Dynamics (CFD) modelling of human cough flow. The cough flow is characterized in two different aspects, the flow field and the droplets. In the study of the flow field of coughing, various dynamic characteristics, including the velocity variation, streamwise penetration and power spectral density, are examined. CFD simulations using two different approaches, the unsteady Reynolds Averaged Navier-Stokes (URANS) and the large eddy simulation (LES), are performed for comparison purposes. The numerical results are validated by the experimental data obtained from the measurements by ...


Uncertainty In Optical Particulate Counting Sensors, Jared Todd Blanchard 2018 Brigham Young University

Uncertainty In Optical Particulate Counting Sensors, Jared Todd Blanchard

Undergraduate Honors Theses

To mitigate the health problems and environmental damage caused by the burning of biomass in homes across the developing world, there is an international effort to design clean burning cookstoves that burn with greater efficiency and emit fewer harmful substances. An important tool for gauging the effectiveness of these alternate stoves is the optical particulate counting (OPC) sensor, which comes in many varieties. To facilitate comparison between measurements from different models, a mathematical model and uncertainty analysis method for OPC’s have been developed. These may be applied to any light-scattering OPC. In addition, a low-cost physical system was developed ...


Multi-Scale Fluid Flow Analysis Of The Cardiovascular System, Zaid Mahmood 2018 Embry-Riddle Aeronautical University

Multi-Scale Fluid Flow Analysis Of The Cardiovascular System, Zaid Mahmood

Dissertations and Theses

The hypoplastic left heart syndrome (HLHS) is one of the rarest congenital heart diseases affecting infants. Out of 150 babies born, one baby suffers from congenital heart disease. Furthermore, nine percent out of those suffering from congenital heart disease specifically suffer from hypoplastic left heart syndrome (HLHS). To this end, the Fontan operation which is a procedure to generate a harmonic blood flow in single functioning ventricle patients has been executed to palliate HLHS patients. In this operation, the inferior vena cava (IVC) and the superior vena cava (SVC), carrying the low-oxygenated blood returning from the lower and upper body ...


Microfluidic Technology And Application In Urinal Analysis, Jiwen Xiang 2018 Louisiana State University and Agricultural and Mechanical College

Microfluidic Technology And Application In Urinal Analysis, Jiwen Xiang

LSU Doctoral Dissertations

Microfluidic technology offers numerous advantages in minimizing and integrating the traditional assays. However, the lack of efficient control components of the microfluidic systems has been hindering the widely commercialization of the technology. The research work in this dissertation focused on the development of effective control components for microfluidic applications.

A linear peristaltic pump was firstly designed, fabricated, and tested for conventional microfluidics by synchronously compressing the microfluidic channel with a miniature cam-follower system in Chapter 2. The miniature cam-follower system and microfluidic chip was prototyped using three-dimensional (3D) printing technology and soft lithography technology. Results from experimental test showed that ...


Electrical Stimulus Controlled Binding/Unbinding Of Human Thrombin-Aptamer Complex, Pranav Shrotriya, Agnivo Gosai, Xiao Ma, Ganesh Balasubraminian 2018 Iowa State University

Electrical Stimulus Controlled Binding/Unbinding Of Human Thrombin-Aptamer Complex, Pranav Shrotriya, Agnivo Gosai, Xiao Ma, Ganesh Balasubraminian

Pranav Shrotriya

The binding/unbinding of the human thrombin and its 15-mer single stranded DNA aptamer, under the application of external stimulus in the form of electrostatic potential/electric field, is investigated by a combination of continuum analysis and atomistic molecular dynamics simulation. In agreement with the experiments that demonstrate the influence of electrostatic potential on the thrombin/aptamer complex, our computations show that the application of positive electric field successfully unbinds the thrombin from the aptamer. Results from umbrella sampling simulations reveal that there is a decrease in the free energy of binding between the thrombin and aptamer in presence of ...


Application Of Pca To Cardiac Optical Mapping, Louis Woodhams 2017 Washington University in St. Louis

Application Of Pca To Cardiac Optical Mapping, Louis Woodhams

Engineering and Applied Science Theses & Dissertations

Structural remodeling of the heart due to pathologies such as hypertension and myocardial infarction leads to the appearance of myofibroblasts, a phenotype largely absent in physiologic myocardium. While myofibroblasts are responsible for wound healing and structural repair of damaged myocardium, they are thought to have deleterious effects on electrical and mechanical properties of the heart. Understanding these effects is critical to developing effective treatments, and has motivated the development of a series of in vitro engineered heart tissues and cardiomyocyte-myofibroblast co-cultures whose mechanical and electrophysiological function can be deduced from video analysis. Electrophysiological properties are evident from changes in intensity ...


Modeling Of A Head - Neck Assembly Drop Tower Impact Test Using Abaqus, Hussein Sharqi Owaid 2017 Hussein.Owaid@maine.edu

Modeling Of A Head - Neck Assembly Drop Tower Impact Test Using Abaqus, Hussein Sharqi Owaid

Electronic Theses and Dissertations

There are numerous potential causes of traumatic brain injury (TBI) and concussions, including traffic accidents, contact during sports and falls. Protection from these injuries is paramount because of the problems that result from TBI, such as loss of thinking and memory capability. Head impact from falls, especially in elderly, can also result in severe to fatal injury and some effects of brain injury are often not visible. For these reasons and more a need exists for protective head gear that can keep persons safe during at risk physical activity and that can protect fall prone persons from accidental injuries. Part ...


Prognosis Of Anterior Cruciate Ligament Reconstruction: A Data-Driven Approach, Abhijit Chandra, Oliva Kar, Kuan Chuen Wu, Michelle Hall, Jason C. Gillette 2017 Iowa State University

Prognosis Of Anterior Cruciate Ligament Reconstruction: A Data-Driven Approach, Abhijit Chandra, Oliva Kar, Kuan Chuen Wu, Michelle Hall, Jason C. Gillette

Jason C Gillette

Individuals who suffer anterior cruciate ligament (ACL) injury are at higher risk of developing knee osteoarthritis (OA) and almost 50% display symptoms 10–20 years post injury. Anterior cruciate ligament reconstruction (ACLR) often does not protect against knee OA development. Accordingly, a multi-scale formulation for data-driven prognosis (DDP) of post-ACLR is developed. Unlike traditional predictive strategies that require controlled off-line measurements or ‘training’ for determination of constitutive parameters to derive the transitional statistics, the proposed DDP algorithm relies solely on in situmeasurements. The proposed DDP scheme is capable of predicting onset of instabilities. As the need for off-line testing ...


Usa Boccia Ball Ramp For Athletes With Quadriplegia, Alissa A. Koukourikos, Nathan Bernards, Matthew Lee 2017 Cal Poly State University San Luis Obispo

Usa Boccia Ball Ramp For Athletes With Quadriplegia, Alissa A. Koukourikos, Nathan Bernards, Matthew Lee

Mechanical Engineering

No abstract provided.


Material Properties Design Using Simulations And Experiments For Powder Injection Molding Of Lead Zirconate Titanate (Pzt)., Bhushan Pramod Bandiwadekar 2017 University of Louisville

Material Properties Design Using Simulations And Experiments For Powder Injection Molding Of Lead Zirconate Titanate (Pzt)., Bhushan Pramod Bandiwadekar

Electronic Theses and Dissertations

Powder injection molding (PIM) process simulations can be performed to minimize the number of injection molding experiments by estimating material properties necessary for PIM simulations. In current work, lead zirconate titanate (PZT) powder-polymer binder feedstock was compounded for 45 vol. % and 52 vol. % solids loading. PIM experiments on designed micro-pillar array geometry were performed using 52 vol. % PZT. Using PIM experiments results as basis, PIM simulations were performed on designed micro-pillar array geometries to understand the effectiveness of PIM simulations with the use of estimated feedstock properties in predicting molding behavior that have micro-features. Additionally, PIM simulations were performed to ...


Dynamic In Vivo Skeletal Feature Tracking Via Fluoroscopy Using A Human Gait Model, William Patrick Anderson 2017 University of Tennessee, Knoxville

Dynamic In Vivo Skeletal Feature Tracking Via Fluoroscopy Using A Human Gait Model, William Patrick Anderson

Doctoral Dissertations

The Tracking Fluoroscope System II, a mobile robotic fluoroscopy platform, developed and built at the University of Tennessee, Knoxville, presently employs a pattern matching algorithm in order to identify and track a marker placed upon a subject’s knee joint of interest. The purpose of this research is to generate a new tracking algorithm based around the human gait cycle for prediction and improving the overall accuracy of joint tracking.

This research centers around processing the acquired x-ray images of the desired knee joint obtained during standard clinical operation in order to identify and track directly through the acquired image ...


Influence Of Scapular Notching On Contact Mechanics And Simulator Wear Of Reverse Total Shoulder Arthroplasty Implants, Michael William Griffiths 2017 The University of Western Ontario

Influence Of Scapular Notching On Contact Mechanics And Simulator Wear Of Reverse Total Shoulder Arthroplasty Implants, Michael William Griffiths

Electronic Thesis and Dissertation Repository

Scapular notching is a common complication of reverse total shoulder arthroplasty (RTSA) wherein the predominant focus of current literature has been on changes in osseous anatomy. However, the implications on RTSA performance from the damaged humeral cup is largely unknown. Therefore the present work describes the effects of the initiation and propagation of the humeral cup defect resulting from scapular notching through the use of finite element modeling and wear simulation, in order to assess changes in RTSA contact mechanics and tribological properties. A significant decrease in articular contact area and increase in maximum contact stress values was found for ...


Design Of A Passive Ankle Prosthesis With Energy Return That Increases With Increasing Walking Velocity, Alexander J. Folz 2017 Marquette University

Design Of A Passive Ankle Prosthesis With Energy Return That Increases With Increasing Walking Velocity, Alexander J. Folz

Master's Theses (2009 -)

Patients who undergo a transtibial (below the knee) amputation are often met with a difficult decision: selection of a prosthesis. Limitations of currently available prostheses motivate work on a new solution, the EaSY Walk, a passive device that mimics two key aspects of the natural ankle: non-linear rotational stiffness through implementation of a stiffening flexure mechanism and rotational work output that varies as a function of walking velocity to propel the user forward. To achieve the latter, a strategy to convert the maximum available translational energy acquired from deflection along the leg into rotational energy about the ankle joint through ...


Experimental Measurements Of Far Field Cough Airflows Produced By Healthy And Influenza- Infected Human Subjects, Ahmed Faraj Alarbi Mohamed 2017 The University of Western Ontario

Experimental Measurements Of Far Field Cough Airflows Produced By Healthy And Influenza- Infected Human Subjects, Ahmed Faraj Alarbi Mohamed

Electronic Thesis and Dissertation Repository

The present work details an experimental study of the cough airflow fields produced by subjects infected with influenza and when they are convalescent, together with data from healthy cohorts. The PIV and HWA measurements were taken far downstream at 1 m from the source within a cough chamber, along with droplet sampling at two different locations and nasal swabs from the sick subjects. The measured data over different seasons were used to evaluate and compare the results from sick, convalescent and healthy subjects. Although a total of 8 sick participants from winter 2014 and 2017 yielded positive nasal swab analysis ...


Application Of Pca To Cardiac Optical Mapping, Louis Woodhams 2017 Washington University in St. Louis

Application Of Pca To Cardiac Optical Mapping, Louis Woodhams

Louis Woodhams

Structural remodeling of the heart due to pathologies such as hypertension and myocardial infarction leads to the appearance of myofibroblasts, a phenotype largely absent in physiologic myocardium. While myofibroblasts are responsible for wound healing and structural repair of damaged myocardium, they are thought to have deleterious effects on electrical and mechanical properties of the heart. Understanding these effects is critical to developing effective treatments, and has motivated the development of a series of in vitro engineered heart tissues and cardiomyocyte-myofibroblast co-cultures whose mechanical and electrophysiological function can be deduced from video analysis. Electrophysiological properties are evident from changes in intensity ...


Cancer Diagnosis By Bioimpedance Spectroscopy And Computer-Assisted Pattern Recognition, Shahriar Shams 2017 Southern Methodist University

Cancer Diagnosis By Bioimpedance Spectroscopy And Computer-Assisted Pattern Recognition, Shahriar Shams

Mechanical Engineering Research Theses and Dissertations

The field of cancer diagnostics has always been one of the most complex and challenging areas in biomedical research, and there has been an increasing demand for more advanced clinical diagnostic equipment over the past four decades. In this thesis, a custom-made coaxial bioimpedance sensor was used, in combination with computer-aided pattern recognition tools, to identify cancer in tissue samples obtained from the formalin-fixed kidney of a 60 year-old male patient. Impedance data was collected using the coaxial sensor at 401 logarithmically-spaced frequency points ranging from 10 kHz to 100 MHz. Principle Component Analysis and Naive Bayes Classification techniques were ...


Bacterial Motility And Its Role In Biofilm Formation, Clayton J. Culp, Arezoo M. Ardekani, Adib Ahmadzadegan 2017 Purdue University

Bacterial Motility And Its Role In Biofilm Formation, Clayton J. Culp, Arezoo M. Ardekani, Adib Ahmadzadegan

The Summer Undergraduate Research Fellowship (SURF) Symposium

Bacterial biofilms are known to cause millions of dollars in damage in the medical industry per year via infection of central venous catheters, urinary catheters, and mechanical heart valves. Unfortunately, there are some characteristics of biofilm formation that are yet to be fully understood. Recently much work has been done to investigate the motility characteristics of bacteria with hopes of better understanding the phenomena of biofilm formation. Still, one of the least understood stages is bacterial attachment or adhesion, a process designed to anchor bacteria in an advantageous environment. Providing a better understanding of bacterial motility near solid interfaces will ...


Comparative Analysis Of Impact Attenuation Properties From Soccer Headgear, Kevin G. McIver, Goutham N. Sankaran, Justin J. Markel, Tom M. Talavage, Larry J. Leverenz, Eric A. Nauman 2017 Purdue University

Comparative Analysis Of Impact Attenuation Properties From Soccer Headgear, Kevin G. Mciver, Goutham N. Sankaran, Justin J. Markel, Tom M. Talavage, Larry J. Leverenz, Eric A. Nauman

The Summer Undergraduate Research Fellowship (SURF) Symposium

Athletes suffering from long-term neurocognitive deficiency due to subconcussive impacts is a major concern for football and soccer players today. Football players wear helmets that can help reduce injury risks like skull fractures, and these helmets must meet standard criteria that determinines how well a functional helmet should reduce accelerations of the player’s head. Currently no standard exists for testing soccer headgear despite studies demonstrating soccer players experience similar magnitudes of impacts. In this study, a modal impact hammer was used in conjunction with a Hybrid III 50th percentile test dummy head to simulate impacts experienced by soccer players ...


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