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174 full-text articles. Page 5 of 8.

Changes In The Ultrastructural Features Of Estrogen Deficient Ovine Bone, Peter Mauer 2014 Royal College of Surgeons in Ireland

Changes In The Ultrastructural Features Of Estrogen Deficient Ovine Bone, Peter Mauer

PhD theses

Osteoporosis is “a skeletal disorder characterised by compromised bone strength predis- posing to an increased risk of fracture” (NIH, 2001). Every second woman and every fifth man will suffer an osteoporotic fracture (Kanis et al., 2000). Of all people that suffer an age-related fracture, the current gold standard of osteoporosis diagnosis, DEXA scanning, misclassifies 80% of them to be non-osteoporotic (Sanders et al., 2006). Bone quantity is easily measured, however, bone strength is an interplay of bone quantity and quality — and the latter is hard to determine. More reliable clinical methods to diagnose osteoporosis are needed as well as widening ...


Assembled Monolayers Depends Upon The Roughness Of The Substrate And The Orientation Of The Terminal Moiety, Lucas B. Newcomb, Ian Tevis, Manza B. J. Atkinson, Symon M. Gathiaka, Rafael E. Luna, Martin M. Thuo 2014 University of Massachusetts Boston

Assembled Monolayers Depends Upon The Roughness Of The Substrate And The Orientation Of The Terminal Moiety, Lucas B. Newcomb, Ian Tevis, Manza B. J. Atkinson, Symon M. Gathiaka, Rafael E. Luna, Martin M. Thuo

Materials Science and Engineering Publications

The origin of the odd even effect in properties of self-assembled monolayers (SAMs) and/or technologies derived from them is poorly understood. We report that hydrophobicity and, hence, surface wetting of SAMs are dominated by the nature of the substrate (surface roughness and identity) and SAM tilt angle, which influences surface dipoles/orientation of the terminal moiety. We measured static contact angles (theta(s)) made by water droplets on n-alkanethiolate SAMs with an odd (SAM(O)) or even (SAM(E)) number of carbons (average theta(s) range of 105.8-112.1 degrees). When SAMs were fabricated on smooth "template-stripped" metal ...


Effect Of Surface Modification And Macrophage Phenotype On Particle Internalization, Daniel Wang, Ngoc Phan, Christopher Isely, Lucas Bruene, Kaitlin M. Bratlie 2014 Iowa State University

Effect Of Surface Modification And Macrophage Phenotype On Particle Internalization, Daniel Wang, Ngoc Phan, Christopher Isely, Lucas Bruene, Kaitlin M. Bratlie

Materials Science and Engineering Publications

Material properties play a key role in the cellular internalization of polymeric particles. In the present study, we have investigated the effects of material characteristics such as water contact angle, zeta potential, melting temperature, and alternative activation of complement on particle internalization for pro-inflammatory, pro-angiogenic, and naïve macrophages by using biopolymers (∼600 nm), functionalized with 13 different molecules. Understanding how material parameters influence particle internalization for different macrophage phenotypes is important for targeted delivery to specific cell populations. Here, we demonstrate that material parameters affect the alternative pathway of complement activation as well as particle internalization for different macrophage phenotypes ...


The Significance Of Macrophage Phenotype In Cancer And Biomaterials, Hannah C. Bygd, Kiva D. Forsmark, Kaitlin M. Bratlie 2014 Iowa State University

The Significance Of Macrophage Phenotype In Cancer And Biomaterials, Hannah C. Bygd, Kiva D. Forsmark, Kaitlin M. Bratlie

Materials Science and Engineering Publications

Macrophages have long been known to exhibit heterogeneous and plastic phenotypes. They show functional diversity with roles in homeostasis, tissue repair, immunity and disease. There exists a spectrum of macrophage phenotypes with varied effector functions, molecular determinants, cytokine and chemokine profiles, as well as receptor expression. In tumor microenvironments, the subset of macrophages known as tumor-associated macrophages generates byproducts that enhance tumor growth and angiogenesis, making them attractive targets for anti-cancer therapeutics. With respect to wound healing and the foreign body response, there is a necessity for balance between pro-inflammatory, wound healing, and regulatory macrophages in order to achieve successful ...


Highly Luminescent Salts Containing Well-Shielded Lanthanide-Centered Complex Anions And Bulky Imidazolium Countercations, Si-Fu Tang, Chantel Lorbeer, Xinjiao Wang, Pushpal Ghosh, Anja V. Mudring 2014 Qingdao Institute of Bioenergy and Bioprocess Technology

Highly Luminescent Salts Containing Well-Shielded Lanthanide-Centered Complex Anions And Bulky Imidazolium Countercations, Si-Fu Tang, Chantel Lorbeer, Xinjiao Wang, Pushpal Ghosh, Anja V. Mudring

Materials Science and Engineering Publications

In this paper, we report on the syntheses, structures, and characterization of four molten salts containing imidazolium cations and europium(III)- or terbium(III)-centered complex anions. In the complex anions, the lanthanide centers are wrapped by four pseudodiketonate anionic ligands, which prevent them from contacting with high-frequency oscillators and allow them to show intense characteristic europium(III) or terbium(III) emission, small line widths, high color purity, high quantum yields (30−49%), and long decay times (>2 ms).


The Development And Biocompatibility Of Low Temperature Co-Fired Ceramic (Ltcc) For Microfluidic And Biosensor Applications, Jin Luo 2014 University of Kentucky

The Development And Biocompatibility Of Low Temperature Co-Fired Ceramic (Ltcc) For Microfluidic And Biosensor Applications, Jin Luo

Theses and Dissertations--Chemical and Materials Engineering

Low temperature co-fired ceramic (LTCC) electronic packaging materials are applied for their electrical and mechanical properties, high reliability, chemical stability and ease of fabrication. Three dimensional features can also be prepared allowing integration of microfluidic channels and cavities inside LTCC modules. Mechanical, optical, electrical, microfluidic functions have been realized in single LTCC modules. For these reasons LTCC is attractive for biomedical microfluidics and Lab-on-a-Chip systems. However, commercial LTCC systems, optimized for microelectrics applications, have unknown cytocompatibility, and are not compatible with common surface functionalization chemistries.

The first goal of this work is to develop biocompatible LTCC materials for biomedical applications ...


Nanometer-Scale Membrane Electrode Systems For Active Protein Separation, Enzyme Immobilization And Cellular Electroporation, Zhiqiang Chen 2014 University of Kentucky

Nanometer-Scale Membrane Electrode Systems For Active Protein Separation, Enzyme Immobilization And Cellular Electroporation, Zhiqiang Chen

Theses and Dissertations--Chemical and Materials Engineering

Automated and continuous processes are the future trends in downstream protein purification. A functionalized nanometer-scale membrane electrode system, mimicking the function of cell wall transporters, can selectively capture genetically modified proteins and subsequently pump them through the system under programmed voltage pulses. Numerical study of the two-step pulse pumping cycles coupled with experimental His-GFP releasing study reveals the optimal 14s/1s pumping/repel pulse pumping condition at 10 mM bulk imidazole concentration in the permeate side. A separation factor for GFP: BSA of 9.7 was achieved with observed GFP electrophoretic mobility of 3.1×10-6 cm2 s ...


Cnt Membrane Platforms For Transdermal Drug Delivery And Aptamer Modulated Transport, Tao Chen 2014 University of Kentucky

Cnt Membrane Platforms For Transdermal Drug Delivery And Aptamer Modulated Transport, Tao Chen

Theses and Dissertations--Chemical and Materials Engineering

CNT membrane platforms are biomimetic polymeric membranes imbedded with carbon nanotubes which show fast fluid flow, electric conductivity, and the ability to be grafted with chemistry. A novel micro-dialysis probe nicotine concentration sampling technique was proposed and proved in vitro, which could greatly improve the efficiency and accuracy of future animal transdermal studies. To enhance the scope of transdermal drug delivery which was limited to passive diffusion of small, potent lipophilic drugs, a wire mesh lateral electroporation design was also proposed which could periodically disrupt the skin barrier and enhance drug flux.

It was shown that AMP binding aptamer at ...


The Advancement Of Bacterial Cellulose As A Bone And Vascular Scaffolds, Ryan Lee Hammonds 2013 University of Tennessee - Knoxville

The Advancement Of Bacterial Cellulose As A Bone And Vascular Scaffolds, Ryan Lee Hammonds

Doctoral Dissertations

Bacterial cellulose (BC) is a natural hydrogel made of nanofibers. This material has been used in commercial products, including wound dressings. BC can be modified and optimized for improved performance in multiple applications. This work will focus on producing and characterizing resorbable cellulose, a composite for bone applications, and a composite for a synthetic venous valve leaflet.

BC can be produced and modified to perform as a degradable tissue scaffold. This is achieved by an oxidation procedure after the initial production and purification of native BC. A material characterization of oxidized BC was performed to identify the changes in properties ...


Iron-Magnesium Alloy Bioabsorbable Blood Stent, Kaitlyn Jarry, L Stanciu 2013 Purdue University

Iron-Magnesium Alloy Bioabsorbable Blood Stent, Kaitlyn Jarry, L Stanciu

The Summer Undergraduate Research Fellowship (SURF) Symposium

Bioabsorbable materials are fairly new and proper alloys for implantation in the body have not yet been established. There are a few polymers that have showed promise, but they do not provide the proper mechanical support that metal does. These materials would be used to create devices such as blood stents and orthopedic screws. Investigation into the properties of different alloys can help to establish a material that can be used for implanted devices that are only needed for a limited amount of time. In order to investigate these alloys many different experiments will to be run to test the ...


Scaling Reversible Adhesion In Synthetic And Biological Systems, Michael D. Bartlett 2013 University of Massachusetts Amherst

Scaling Reversible Adhesion In Synthetic And Biological Systems, Michael D. Bartlett

Michael Bartlett

Geckos and other insects have fascinated scientists and casual observers with their
ability to effortlessly climb up walls and across ceilings. This capability has inspired
high capacity, easy release synthetic adhesives, which have focused on mimicking the
fibrillar features found on the foot pads of these climbing organisms. However, without a
fundamental framework that connects biological and synthetic adhesives from
nanoscopic to macroscopic features, synthetic mimics have failed to perform favorably at
large contact areas. In this thesis, we present a scaling approach which leads to an
understanding of reversible adhesion in both synthetic and biological systems over
multiple length ...


Materials Education And Research In Art And Design: A New Role For Libraries (Program Sheet), Mark Pompelia 2013 Rhode Island School of Design

Materials Education And Research In Art And Design: A New Role For Libraries (Program Sheet), Mark Pompelia

Materials Education and Research in Art and Design: A New Role for Libraries

No abstract provided.


Materials Education And Research In Art And Design: A New Role For Libraries (Survey Stats), Mark Pompelia 2013 Rhode Island School of Design

Materials Education And Research In Art And Design: A New Role For Libraries (Survey Stats), Mark Pompelia

Materials Education and Research in Art and Design: A New Role for Libraries

No abstract provided.


Materials Education And Research In Art And Design: A New Role For Libraries (Program Booklet), Mark Pompelia 2013 Rhode Island School of Design

Materials Education And Research In Art And Design: A New Role For Libraries (Program Booklet), Mark Pompelia

Materials Education and Research in Art and Design: A New Role for Libraries

No abstract provided.


Materials Education And Research In Art And Design: A New Role For Libraries (Website), Mark Pompelia 2013 Rhode Island School of Design

Materials Education And Research In Art And Design: A New Role For Libraries (Website), Mark Pompelia

Materials Education and Research in Art and Design: A New Role for Libraries

No abstract provided.


Materials Collection Creation And Administration: A New Role For Libraries (White Paper), Mark Pompelia 2013 Rhode Island School of Design

Materials Collection Creation And Administration: A New Role For Libraries (White Paper), Mark Pompelia

Materials Education and Research in Art and Design: A New Role for Libraries

The Problem/Opportunity: To define, identify, and guide design-based materials collections in academic settings and foster community among those with existing collections and/or those considering creating and supporting one.

Contents and topics:

  1. What is a materials collection?
  2. Why have a materials collection?
  3. Acquisition strategies
  4. Organizational approaches
  5. Programming possibilities
  6. Symposium summary
  7. Resources


Strength Testing And Material Characterization Of Cactus Spines, Mary Cooper, Jeff Goldstein, Thomas Tarlton 2013 California Polytechnic State University - San Luis Obispo

Strength Testing And Material Characterization Of Cactus Spines, Mary Cooper, Jeff Goldstein, Thomas Tarlton

Materials Engineering

Twelve different species of cactus spines from 6 different genera were collected from living specimens and maintained in a dry storage environment. Spines from each species underwent 3-point bend testing, XRD testing, and SEM imaging. XRD analysis was used to verify the presence of cellulose whisker like nanocrystals and to calculate the percent crystallinity of each spine. SEM images were captured of fracture surfaces at viewing angles of 90° and 45° relative to the fracture surface, with magnifications ranging between 150x and 4,000x. A total of six spines from each species were tested in three point bending using a ...


An Investigation Of Arabinan And Cellulose Based Nano-Composite Fabrication Methods, Marianne Smithfield, Carl Petterson, Robert Miller 2013 California Polytechnic State University - San Luis Obispo

An Investigation Of Arabinan And Cellulose Based Nano-Composite Fabrication Methods, Marianne Smithfield, Carl Petterson, Robert Miller

Materials Engineering

Microcrystalline cellulose was converted into nanocrystalline cellulose via an acid hydrolysis procedure. Scanning electron microscopy (SEM) was employed to measure the particle size and thus the effectiveness of acid hydrolysis. The nanocrystalline cellulose was poured through a 0.2μm filter to isolate the particles of ideal size. The nanocrystalline cellulose samples were stored in dimethylformamide (DMF) to prevent mold growth and agglomeration upon drying. Numerous composite samples were created by dissolving the arabinan in a solvent, suspending cellulose in the arabinan solution, and then drying the sample. Casting was performed in a silicon mold to allow sample removal without damage ...


Development Of A High Precision Quantum Dot Synthysis Method Utilizing A Microfluidic Reactor And In-Line Fluorescence Cell, Harry Lafferty, Jonny Hoadley 2013 California Polytechnic State University - San Luis Obispo

Development Of A High Precision Quantum Dot Synthysis Method Utilizing A Microfluidic Reactor And In-Line Fluorescence Cell, Harry Lafferty, Jonny Hoadley

Materials Engineering

Quantum dots show great potential for use as spectral converters in solar cells, lighting applications and biological imaging. These applications require precise control of quantum dot size to maximize performance. The fluorescence profile of quantum dots in solution correlates directly with particle size. An alternative, high precision process was developed for the synthesis of cadmium-selenide quantum dots using a microfluidic reactor and fluorescence flow through cell. The process required creating separate cadmium and selenium precursors that were then mixed in a nitrogen environment at 17± 1°C. Using an NE-300® syringe pump, the solution was pumped through a microfluidic reactor ...


Sol-Gel Derived Biodegradable And Bioactive Organic-Inorganic Hybrid Biomaterials For Bone Tissue Engineering, Bedilu A. Allo 2013 The University of Western Ontario

Sol-Gel Derived Biodegradable And Bioactive Organic-Inorganic Hybrid Biomaterials For Bone Tissue Engineering, Bedilu A. Allo

Electronic Thesis and Dissertation Repository

Treatments of bone injuries and defects have been largely centered on replacing the lost bone with tissues of allogeneic or xenogeneic sources as well as synthetic bone substitutes, which in all lead to limited degree of structural and functional recovery. As a result, tissue engineering has emerged as a viable technology to regenerate the structures and therefore recover the functions of bone tissue rather than replacement alone. Hence, the current strategies of bone tissue engineering and regeneration rely on bioactive scaffolds to mimic the natural extracellular matrix (ECM) as templates onto which cells attach, multiply, migrate and function.

In this ...


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