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191 full-text articles. Page 5 of 9.

Limits To The Effect Of Substrate Roughness Or Smoothness On The Odd–Even Effect In Wetting Properties Of N-Alkanethiolate Monolayers, Jiahao Chen, Zhengjia Wang, Stephanie Oyola-Reynoso, Symon M. Gathiaka, Martin M. Thuo 2015 Iowa State University

Limits To The Effect Of Substrate Roughness Or Smoothness On The Odd–Even Effect In Wetting Properties Of N-Alkanethiolate Monolayers, Jiahao Chen, Zhengjia Wang, Stephanie Oyola-Reynoso, Symon M. Gathiaka, Martin M. Thuo

Materials Science and Engineering Publications

This study investigates the effect of roughness on interfacial properties of an n-alkanethiolate self-assembled monolayer (SAM) and uses hydrophobicity to demonstrate the existence of upper and lower limits. This article also sheds light on the origin of the previously unexplained gradual increase in contact angles with increases in the size of the molecule making the SAM. We prepared Au surfaces with a root-mean-square (RMS) roughness of ∼0.2–0.5 nm and compared the wetting properties of n-alkanethiolate (C10–C16) SAMs fabricated on these surfaces. Static contact angles, θs, formed between the SAM and water, diethylene glycol, and ...


The Porter-Whitesides Discrepancy: Revisiting Odd-Even Effects In Wetting Properties Of N-Alkanethiolate Sams, Zhengjia Wang, Jiahao Chen, Stephanie Oyola-Reynoso, Martin M. Thuo 2015 Iowa State University

The Porter-Whitesides Discrepancy: Revisiting Odd-Even Effects In Wetting Properties Of N-Alkanethiolate Sams, Zhengjia Wang, Jiahao Chen, Stephanie Oyola-Reynoso, Martin M. Thuo

Materials Science and Engineering Publications

This review discusses the Porter-Whitesides discrepancy in wetting properties of n-alkanethiolate self-assembled monolayers (SAMs). About 25 years ago, Whitesides and coworker failed to observe any odd-even effect in wetting, however, Porter and his coworker did, albeit in select cases. Most previous studies agreed with Whitesides’ results, suggesting the absence of the odd-even effect in hydrophobicity of n-alkanethiolate SAMs. Recent reports have, however, found the odd-even effect in hydrophobicity of n-alkanethiolate SAMs on smooth substrates, indicating that hydrophobicity, and analogous interfacial properties, of n-alkanethiolate SAMs significantly depends on the properties of substrate. Unfortunately, the Whitesides and Porter papers do not report ...


Effect Of Surface Hydrophobicity On The Function Of The Immobilized Biomineralization Protein Mms6, Xunpei Liu, Honghu Zhang, Srikanth Nayak, German Parada, James W. Anderegg, Shuren Feng, Marit Nilsen-Hamilton, Mufit Akinc, Surya K. Mallapragada 2015 Iowa State University

Effect Of Surface Hydrophobicity On The Function Of The Immobilized Biomineralization Protein Mms6, Xunpei Liu, Honghu Zhang, Srikanth Nayak, German Parada, James W. Anderegg, Shuren Feng, Marit Nilsen-Hamilton, Mufit Akinc, Surya K. Mallapragada

Biochemistry, Biophysics and Molecular Biology Publications

Magnetotactic bacteria produce magnetic nanocrystals with uniform shapes and sizes in nature, which has inspired in vitro synthesis of uniformly sized magnetite nanocrystals under mild conditions. Mms6, a biomineralization protein from magnetotactic bacteria with a hydrophobic N-terminal domain and a hydrophilic C-terminal domain, can promote formation of magnetite nanocrystals in vitro with well-defined shape and size in gels under mild conditions. Here we investigate the role of surface hydrophobicity on the ability of Mms6 to template magnetite nanoparticle formation on surfaces. Our results confirmed that Mms6 can form a protein network structure on a monolayer of hydrophobic octadecanethiol (ODT)-coated ...


Quantitative Characterization Of Collagen In The Fibrotic Capsule Surrounding Implanted Polymeric Microparticles Through Second Harmonic Generation Imaging, Dana Akilbekova, Kaitlin M. Bratlie 2015 Iowa State University

Quantitative Characterization Of Collagen In The Fibrotic Capsule Surrounding Implanted Polymeric Microparticles Through Second Harmonic Generation Imaging, Dana Akilbekova, Kaitlin M. Bratlie

Materials Science and Engineering Publications

The collagenous capsule formed around an implant will ultimately determine the nature of its in vivo fate. To provide a better understanding of how surface modifications can alter the collagen orientation and composition in the fibrotic capsule, we used second harmonic generation (SHG) microscopy to evaluate collagen organization and structure generated in mice subcutaneously injected with chemically functionalized polystyrene particles. SHG is sensitive to the orientation of a molecule, making it a powerful tool for measuring the alignment of collagen fibers. Additionally, SHG arises from the second order susceptibility of the interrogated molecule in response to the electric field. Variation ...


Influence Of Polymer Chemistry On Cytokine Secretion From Polarized Macrophages, Daniel Wang, Kaitlin M. Bratlie 2015 Iowa State University

Influence Of Polymer Chemistry On Cytokine Secretion From Polarized Macrophages, Daniel Wang, Kaitlin M. Bratlie

Materials Science and Engineering Publications

Of central importance to tissue engineering and drug delivery is identifying polymer parameters that increase or decrease specific cytokines in response to biomaterials. In this study, we have interrogated the effects of material descriptors and material characteristics on pro-inflammatory, pro-angiogenic, and naïve macrophages using polymeric particles (∼600 nm), functionalized with 13 different moieties. We characterized tumor necrosis factor-α (TNF-α) and interleukin-10 (IL-10) secretion for the three macrophage populations and used the quantitative structure–activity relationship method (QSAR) to accurately predict cytokine secretion for the different macrophage phenotypes. The findings presented here demonstrate that altering cellular responses to polymers can be ...


Double- And Multi-Sided Adhesive Devices: Patent Application, Alfred J. Crosby, Michael D. Bartlett 2014 University of Massachusetts - Amherst

Double- And Multi-Sided Adhesive Devices: Patent Application, Alfred J. Crosby, Michael D. Bartlett

Michael Bartlett

The invention provides unique releasable adhesive devices and related methods that are capable of simultaneously adhering to two or multiple target surfaces of various nature and allow high load capacity, are reusable, easy release and suitable for extended and repeated use.


An Investigation On Biocompatibility Of Bio-Absorbable Polymer Coated Magnesium Alloys, Sushma Amruthaluri 2014 Florida International University

An Investigation On Biocompatibility Of Bio-Absorbable Polymer Coated Magnesium Alloys, Sushma Amruthaluri

FIU Electronic Theses and Dissertations

Advances in biomaterials have enabled medical practitioners to replace diseased body parts or to assist in the healing process. In situations where a permanent biomaterial implant is used for a temporary application, additional surgeries are required to remove these implants once the healing process is complete, which increases medical costs and patient morbidity. Bio-absorbable materials dissolve and are metabolized by the body after the healing process is complete thereby negating additional surgeries for removal of implants.

Magnesium alloys as novel bio-absorbable biomaterials, have attracted great attention recently because of their good mechanical properties, biocompatibility and corrosion rate in physiological environments ...


Fabrication Of 3d Ultrafine Fibrous Protein Structures Via Freeze-Drying, Yiling Huang 2014 University of Nebraska-Lincoln

Fabrication Of 3d Ultrafine Fibrous Protein Structures Via Freeze-Drying, Yiling Huang

Textiles, Merchandising and Fashion Design: Dissertations, Theses, & Student Research

In this thesis, ultrafine fibrous 3D matrices were fabricated using three different proteins (soy protein, wool keratin, and chicken feather keratin) via freeze-drying. Protein matrices are preferable for tissue engineering compared to matrices made from synthetic material because of their similarity to native extracellular matrices. Due to their cell-binding motifs, natural proteins are also recognized as more biocompatible compared. Freeze-drying, which is a simple method used to produce 3D sponge matrices, was employed in this study to fabricate 3D fibrous matrices in a controlled manner. The inner structures of the 3D matrices fabricated ranged from film to fibers, and the ...


Devices For Application And Load Bearing And Method Of Using The Same: Patent Application, Alfred J. Crosby, Michael D. Bartlett, Duncan J. Irschick, Daniel R. King 2014 University of Massachusetts - Amherst

Devices For Application And Load Bearing And Method Of Using The Same: Patent Application, Alfred J. Crosby, Michael D. Bartlett, Duncan J. Irschick, Daniel R. King

Michael Bartlett

Gecko-like adhesive application devices suited for dynamic applications are disclosed, where the device can be easily applied to target substrates, exhibiting a firm hold, and subsequently released therefrom. Gecko-like adhesive application devices that are suited for sustained holding after easy application (e.g., on vertical or inclined surfaces or ceiling) also are disclosed.


Effect Of Plasticizer On Oxygen Permeability Of Cast Polylactic Acid (Pla) Films Determined Using Dynamic Accumulation Method, Kurniawan Yuniarto, Bruce A. Welt, ARIS PURWANTO, Hadi Karia Purwadaria, Ayman Abdellatief, Titi C. Sunarti, Setyo Purwanto 2014 Bogor Agricultural University

Effect Of Plasticizer On Oxygen Permeability Of Cast Polylactic Acid (Pla) Films Determined Using Dynamic Accumulation Method, Kurniawan Yuniarto, Bruce A. Welt, Aris Purwanto, Hadi Karia Purwadaria, Ayman Abdellatief, Titi C. Sunarti, Setyo Purwanto

Journal of Applied Packaging Research

Polylactic acid (PLA) is becoming an increasingly important biopolymer for packaging applications. PLA brittleness limits its applicability. This study evaluated PLA properties with increasing amounts of added polyethylene glycol (PEG) plasticizer. Oxygen transmission rate (OTR) of cast films was determined using the newly available Dynamic Accumulation (DA) method. Arrhenius temperature sensitivity of OTR and polymer Permeability was also determined. Permeability of neat PLA is 4.848 ml mm (STP)/m2 s kPa; hence, 4.84 ml mm (STP)/m2 s kPa, 4.07 ml mm (STP)/m2 s kPa and 5.42 ml mm (STP)/m2 ...


A Collagen‐Glycosaminoglycan‐Fibrin Scaffold For Heart Valve Tissue Engineering Applications, Claire Brougham, Stefan Jockenhoevel, Thomas Flanagan, Fergal O'Brien 2014 Dublin Institute of Technology

A Collagen‐Glycosaminoglycan‐Fibrin Scaffold For Heart Valve Tissue Engineering Applications, Claire Brougham, Stefan Jockenhoevel, Thomas Flanagan, Fergal O'Brien

Conference Papers

The field of heart valve biology and tissue engineering a heart valve continue to expand. The presentatio ns at this meeting reflect the advances made in both areas due to the multi-disciplinary approach taken by many laboratories.


Scalable Functional Bone Substitutes: Strategic Integration Of Key Structural Elements Of Bone In Synthetic Biomaterials, Tera M. Filion, Jie Song 2014 University of Massachusetts Medical School

Scalable Functional Bone Substitutes: Strategic Integration Of Key Structural Elements Of Bone In Synthetic Biomaterials, Tera M. Filion, Jie Song

Jie Song

Summary: Introduces recent advances in the evolvement of non-metallic orthopedic biomaterials in the design of organic-inorganic composite bone substitutes. Citation: Tera M. Filion and Jie Song (2011). Scalable Functional Bone Substitutes: Strategic Integration of Key Structural Elements of Bone in Synthetic Biomaterials, Biomedical Engineering - Frontiers and Challenges, Reza Fazel-Rezai (Ed.), ISBN: 978-953-307-309-5, InTech, Available from: http://www.intechopen.com/articles/show/title/scalable-functional-bone-substitutes-strategic-integration-of-key-structural-elements-of-bone-in-syn


Chemically Modified Cellulose Fibrous Meshes For Use As Tissue Engineering Scaffolds, Tera Filion, Artem Kutikov, Jie Song 2014 University of Massachusetts Medical School

Chemically Modified Cellulose Fibrous Meshes For Use As Tissue Engineering Scaffolds, Tera Filion, Artem Kutikov, Jie Song

Jie Song

Cellulose and sulfated cellulose fibrous meshes exhibiting robust structural and mechanical integrity in water were fabricated using a combination of electrospinning, thermal-mechanical annealing and chemical modifications. The sulfated fibrous mesh exhibited higher retention capacity for human recombinant bone morphogenetic protein-2 than the cellulose mesh, and the retained proteins remained biologically active for at least 7 days. The sulfated fibrous mesh also more readily supported the attachment and osteogenic differentiation of rat bone marrow stromal cells in the absence of osteogenic growth factors. These properties combined make the sulfated cellulose fibrous mesh a promising bone tissue engineering scaffold.


Elastomeric High-Mineral Content Hydrogel-Hydroxyapatite Composites For Orthopedic Applications, Jie Song, Jianwen Xu, Tera Filion, Eduardo Saiz, Antoni Tomsia, Jane Lian, Gary Stein, David Ayers, Carolyn Bertozzi 2014 University of Massachusetts Medical School

Elastomeric High-Mineral Content Hydrogel-Hydroxyapatite Composites For Orthopedic Applications, Jie Song, Jianwen Xu, Tera Filion, Eduardo Saiz, Antoni Tomsia, Jane Lian, Gary Stein, David Ayers, Carolyn Bertozzi

Jie Song

The design of synthetic bone grafts that mimic the structure and composition of bone and possess good surgical handling characteristics remains a major challenge. We report the development of poly(2-hydroxyethyl methacrylate) (pHEMA)-hydroxyapatite (HA) composites termed "FlexBone" that possess osteoconductive mineral content approximating that of human bone yet exhibit elastomeric properties enabling the press-fitting into a defect site. The approach involves crosslinking pHEMA hydrogel in the presence of HA using viscous ethylene glycol as a solvent. The composites exhibit excellent structural integration between the apatite mineral component and the hydroxylated hydrogel matrix. The stiffness of the composite and the ...


Optical Resonators And Fiber Tapers As Transducers For Detection Of Nanoparticles And Bio-Molecules, Huzeyfe Yilmaz 2014 Washington University in St Louis

Optical Resonators And Fiber Tapers As Transducers For Detection Of Nanoparticles And Bio-Molecules, Huzeyfe Yilmaz

Engineering and Applied Science Theses & Dissertations

In recent years, detection of biological interactions on single molecule level has aspired many researchers to investigate several optical, chemical, electrical and mechanical sensing tools. Among these tools, toroidal optical resonators lead the way in detection of the smallest particle/molecule with the real time measurements. In this work, bio-sensing capabilities of toroidal optical resonators are investigated. Bio-sensing is realized via measuring the analyte-antigen interaction while the antigen is immobilized through a novel functionalization method.

Not long ago, detection of single nanoparticles using optical resonators has been accomplished however the need for cost-effective and practical transducers demands simpler tools. A ...


Surgical Adhesive From Mussel Mimetic Polymer, Jenna DeSousa, Cori Jenkins, Jonathan Wilker 2014 Purdue University

Surgical Adhesive From Mussel Mimetic Polymer, Jenna Desousa, Cori Jenkins, Jonathan Wilker

The Summer Undergraduate Research Fellowship (SURF) Symposium

Injuries involving damaged tissues are currently repaired through an invasive technique involving the use of screws, plates and sutures as support, which can damage these tissues. The biomedical field currently lacks an adhesive that can replace harmful implants. A surgical adhesive can provide a quick and easy alternative, which will minimize the risk of damaging healthy tissue in surgery. Inspiration for such materials can be found by looking at marine mussels as they are able to stick to nearly any surface, even in wet environments. Marine mussels affix themselves to different surfaces using adhesive plaques consisting of various proteins. Polymer ...


Characterization Of Swelling Ratio And Water Content Of Hydrogels For Cartilage Engineering Applications, Emily E. Gill, Renay S.-C. Su, Julie C. Liu 2014 Purdue University

Characterization Of Swelling Ratio And Water Content Of Hydrogels For Cartilage Engineering Applications, Emily E. Gill, Renay S.-C. Su, Julie C. Liu

The Summer Undergraduate Research Fellowship (SURF) Symposium

Due to the high prevalence of arthritis and cartilage-related injuries, tissue engineers are studying ways to grow cartilage tissue replacements. Resilin, an elastomeric protein found in insect cuticles, is known for its extraordinary resilience and elasticity. In previous studies, recombinant resilin-based hydrogels, or cross-linked protein networks, exhibited potential for use in cartilage tissue scaffolds. Our lab successfully developed resilin-based proteins with a sequence based on the mosquito gene and showed that resilin-based hydrogels possess mechanical properties of the same order of magnitude as native articular cartilage. In addition, these mechanical properties can be controlled by changing the protein concentration. To ...


Biological Implications Of Satellite Cells For Scaffold-Based Muscle Regenerative Engineering, Maggie R. Del Ponte, Charter Chain, Meng Deng Dr., Feng Yue Dr., Shihuan Kuang Dr. 2014 Purdue University

Biological Implications Of Satellite Cells For Scaffold-Based Muscle Regenerative Engineering, Maggie R. Del Ponte, Charter Chain, Meng Deng Dr., Feng Yue Dr., Shihuan Kuang Dr.

The Summer Undergraduate Research Fellowship (SURF) Symposium

Satellite cells are anatomically localized along the surface of muscle fibers and have been regarded as a population of muscle-specific progenitors that are responsible for muscle regeneration. In response to muscle injuries, satellite cells are activated to enter the cell cycle, then proliferate and differentiate into mature muscle cells to regenerate damaged myofibers. Unfortunately, this natural repair mechanism is interrupted in conditions such as muscle degenerative diseases or volumetric muscle loss. The function of stem cells is regulated by signals from their local microenvironment which is called the stem cell niche. Current satellite cell-based strategies such as direct cell transplantation ...


Design And Fabrication Of A Novel Electrospinning System For Musculoskeletal Tissue Regeneration, Carter L. Chain, Maggie R. Del Ponte, Meng Deng, Feng Yue, Shihuan Kuang 2014 Purdue University

Design And Fabrication Of A Novel Electrospinning System For Musculoskeletal Tissue Regeneration, Carter L. Chain, Maggie R. Del Ponte, Meng Deng, Feng Yue, Shihuan Kuang

The Summer Undergraduate Research Fellowship (SURF) Symposium

Disease and injury to human tissue, especially musculoskeletal tissue, is a prevalent concern to the public, affecting millions of people each year. Current treatment options involving autografts and allografts are hindered by limited availability and risk of immunogenicity, respectively. In order to overcome these limitations, a transdisiplinary regenerative engineering strategy has emerged with a focus on the development of biomimetic scaffolds that closely mimic the properties of the native tissues. For example, the structure of muscle tissue is characterized by oriented muscle fibers. However, fabrication of aligned nanofiber structures that mimic the anisotropic organization of muscle presents significant engineering challenges ...


The Role Of Metal Oxide Layers In The Sensitivity Of Lactate Biosensors Subjected To Oxygen-Limited Conditions, Elizabeth Andreasen, Lia Stanciu, Aytekin Uzunoglu 2014 Purdue University

The Role Of Metal Oxide Layers In The Sensitivity Of Lactate Biosensors Subjected To Oxygen-Limited Conditions, Elizabeth Andreasen, Lia Stanciu, Aytekin Uzunoglu

The Summer Undergraduate Research Fellowship (SURF) Symposium


Amperometric lactate biosensors are used to detect lactate concentration in blood and tissues, which is integral in identifying cyanide poisoning, septic shock, and athletic condition. The construction of lactate biosensors with high sensitivity, selectivity, and stability is imperative to diagnose and determine these medical conditions. Lactate detection is currently limited to oxygen-rich environments due to the fact that oxygen is a limiting factor in the lactate reaction. To circumvent this problem, researchers have developed mediators or alternate, oxygen-free enzymes to improve sensitivity. In our study, ceria (CeO2) with high oxygen storage capacity (OSC) was introduced to the enzyme layer ...


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