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Surface-Enhanced Raman Spectroscopy-Based Biomarker Detection For B-Cell Malignancies, Nathan Israelsen 2015 Utah State University

Surface-Enhanced Raman Spectroscopy-Based Biomarker Detection For B-Cell Malignancies, Nathan Israelsen

All Graduate Theses and Dissertations

This thesis presents a light scattering-based method for biomarker detection, which could potentially be used for the quantification of multiple biomarkers specific to B-cell malignancies. This method uses fabricated gold nanoparticle probes to amplify inelastic light scattering in a process referred to as surface-enhanced Raman scattering. These gold nanoparticle probes were conjugated to antibodies for specific and targeted molecular binding. The spectrum of the amplified inelastic light scattering was detected using a spectrometer and a detector. To detect the light scattering signal from the gold nanoparticle probes, several commercial Raman spectrometer instruments were evaluated. Initial results from these evaluations are ...


Double- And Multi-Sided Adhesive Devices: Patent Application, Alfred J. Crosby, Michael D. Bartlett 2014 University of Massachusetts - Amherst

Double- And Multi-Sided Adhesive Devices: Patent Application, Alfred J. Crosby, Michael D. Bartlett

Michael Bartlett

The invention provides unique releasable adhesive devices and related methods that are capable of simultaneously adhering to two or multiple target surfaces of various nature and allow high load capacity, are reusable, easy release and suitable for extended and repeated use.


An Investigation On Biocompatibility Of Bio-Absorbable Polymer Coated Magnesium Alloys, Sushma Amruthaluri 2014 Florida International University

An Investigation On Biocompatibility Of Bio-Absorbable Polymer Coated Magnesium Alloys, Sushma Amruthaluri

FIU Electronic Theses and Dissertations

Advances in biomaterials have enabled medical practitioners to replace diseased body parts or to assist in the healing process. In situations where a permanent biomaterial implant is used for a temporary application, additional surgeries are required to remove these implants once the healing process is complete, which increases medical costs and patient morbidity. Bio-absorbable materials dissolve and are metabolized by the body after the healing process is complete thereby negating additional surgeries for removal of implants.

Magnesium alloys as novel bio-absorbable biomaterials, have attracted great attention recently because of their good mechanical properties, biocompatibility and corrosion rate in physiological environments ...


Fabrication Of 3d Ultrafine Fibrous Protein Structures Via Freeze-Drying, Yiling Huang 2014 University of Nebraska-Lincoln

Fabrication Of 3d Ultrafine Fibrous Protein Structures Via Freeze-Drying, Yiling Huang

Textiles, Merchandising and Fashion Design: Dissertations, Theses, & Student Research

In this thesis, ultrafine fibrous 3D matrices were fabricated using three different proteins (soy protein, wool keratin, and chicken feather keratin) via freeze-drying. Protein matrices are preferable for tissue engineering compared to matrices made from synthetic material because of their similarity to native extracellular matrices. Due to their cell-binding motifs, natural proteins are also recognized as more biocompatible compared. Freeze-drying, which is a simple method used to produce 3D sponge matrices, was employed in this study to fabricate 3D fibrous matrices in a controlled manner. The inner structures of the 3D matrices fabricated ranged from film to fibers, and the ...


Devices For Application And Load Bearing And Method Of Using The Same: Patent Application, Alfred J. Crosby, Michael D. Bartlett, Duncan J. Irschick, Daniel R. King 2014 University of Massachusetts - Amherst

Devices For Application And Load Bearing And Method Of Using The Same: Patent Application, Alfred J. Crosby, Michael D. Bartlett, Duncan J. Irschick, Daniel R. King

Michael Bartlett

Gecko-like adhesive application devices suited for dynamic applications are disclosed, where the device can be easily applied to target substrates, exhibiting a firm hold, and subsequently released therefrom. Gecko-like adhesive application devices that are suited for sustained holding after easy application (e.g., on vertical or inclined surfaces or ceiling) also are disclosed.


Effect Of Plasticizer On Oxygen Permeability Of Cast Polylactic Acid (Pla) Films Determined Using Dynamic Accumulation Method, Kurniawan Yuniarto, Bruce A. Welt, ARIS PURWANTO, Hadi Karia Purwadaria, Ayman Abdellatief, Titi C. Sunarti, Setyo Purwanto 2014 Bogor Agricultural University

Effect Of Plasticizer On Oxygen Permeability Of Cast Polylactic Acid (Pla) Films Determined Using Dynamic Accumulation Method, Kurniawan Yuniarto, Bruce A. Welt, Aris Purwanto, Hadi Karia Purwadaria, Ayman Abdellatief, Titi C. Sunarti, Setyo Purwanto

Journal of Applied Packaging Research

Polylactic acid (PLA) is becoming an increasingly important biopolymer for packaging applications. PLA brittleness limits its applicability. This study evaluated PLA properties with increasing amounts of added polyethylene glycol (PEG) plasticizer. Oxygen transmission rate (OTR) of cast films was determined using the newly available Dynamic Accumulation (DA) method. Arrhenius temperature sensitivity of OTR and polymer Permeability was also determined. Permeability of neat PLA is 4.848 ml mm (STP)/m2 s kPa; hence, 4.84 ml mm (STP)/m2 s kPa, 4.07 ml mm (STP)/m2 s kPa and 5.42 ml mm (STP)/m2 ...


A Collagen‐Glycosaminoglycan‐Fibrin Scaffold For Heart Valve Tissue Engineering Applications, Claire Brougham, Stefan Jockenhoevel, Thomas Flanagan, Fergal O'Brien 2014 Dublin Institute of Technology

A Collagen‐Glycosaminoglycan‐Fibrin Scaffold For Heart Valve Tissue Engineering Applications, Claire Brougham, Stefan Jockenhoevel, Thomas Flanagan, Fergal O'Brien

Conference Papers

The field of heart valve biology and tissue engineering a heart valve continue to expand. The presentatio ns at this meeting reflect the advances made in both areas due to the multi-disciplinary approach taken by many laboratories.


Scalable Functional Bone Substitutes: Strategic Integration Of Key Structural Elements Of Bone In Synthetic Biomaterials, Tera Filion, Jie Song 2014 University of Massachusetts Medical School

Scalable Functional Bone Substitutes: Strategic Integration Of Key Structural Elements Of Bone In Synthetic Biomaterials, Tera Filion, Jie Song

Jie Song

Summary: Introduces recent advances in the evolvement of non-metallic orthopedic biomaterials in the design of organic-inorganic composite bone substitutes. Citation: Tera M. Filion and Jie Song (2011). Scalable Functional Bone Substitutes: Strategic Integration of Key Structural Elements of Bone in Synthetic Biomaterials, Biomedical Engineering - Frontiers and Challenges, Reza Fazel-Rezai (Ed.), ISBN: 978-953-307-309-5, InTech, Available from: http://www.intechopen.com/articles/show/title/scalable-functional-bone-substitutes-strategic-integration-of-key-structural-elements-of-bone-in-syn


Chemically Modified Cellulose Fibrous Meshes For Use As Tissue Engineering Scaffolds, Tera Filion, Artem Kutikov, Jie Song 2014 University of Massachusetts Medical School

Chemically Modified Cellulose Fibrous Meshes For Use As Tissue Engineering Scaffolds, Tera Filion, Artem Kutikov, Jie Song

Jie Song

Cellulose and sulfated cellulose fibrous meshes exhibiting robust structural and mechanical integrity in water were fabricated using a combination of electrospinning, thermal-mechanical annealing and chemical modifications. The sulfated fibrous mesh exhibited higher retention capacity for human recombinant bone morphogenetic protein-2 than the cellulose mesh, and the retained proteins remained biologically active for at least 7 days. The sulfated fibrous mesh also more readily supported the attachment and osteogenic differentiation of rat bone marrow stromal cells in the absence of osteogenic growth factors. These properties combined make the sulfated cellulose fibrous mesh a promising bone tissue engineering scaffold.


Elastomeric High-Mineral Content Hydrogel-Hydroxyapatite Composites For Orthopedic Applications, Jie Song, Jianwen Xu, Tera Filion, Eduardo Saiz, Antoni Tomsia, Jane Lian, Gary Stein, David Ayers, Carolyn Bertozzi 2014 University of Massachusetts Medical School

Elastomeric High-Mineral Content Hydrogel-Hydroxyapatite Composites For Orthopedic Applications, Jie Song, Jianwen Xu, Tera Filion, Eduardo Saiz, Antoni Tomsia, Jane Lian, Gary Stein, David Ayers, Carolyn Bertozzi

Jie Song

The design of synthetic bone grafts that mimic the structure and composition of bone and possess good surgical handling characteristics remains a major challenge. We report the development of poly(2-hydroxyethyl methacrylate) (pHEMA)-hydroxyapatite (HA) composites termed "FlexBone" that possess osteoconductive mineral content approximating that of human bone yet exhibit elastomeric properties enabling the press-fitting into a defect site. The approach involves crosslinking pHEMA hydrogel in the presence of HA using viscous ethylene glycol as a solvent. The composites exhibit excellent structural integration between the apatite mineral component and the hydroxylated hydrogel matrix. The stiffness of the composite and the ...


Design And Fabrication Of A Novel Electrospinning System For Musculoskeletal Tissue Regeneration, Carter L. Chain, Maggie R. Del Ponte, Meng Deng, Feng Yue, Shihuan Kuang 2014 Purdue University

Design And Fabrication Of A Novel Electrospinning System For Musculoskeletal Tissue Regeneration, Carter L. Chain, Maggie R. Del Ponte, Meng Deng, Feng Yue, Shihuan Kuang

The Summer Undergraduate Research Fellowship (SURF) Symposium

Disease and injury to human tissue, especially musculoskeletal tissue, is a prevalent concern to the public, affecting millions of people each year. Current treatment options involving autografts and allografts are hindered by limited availability and risk of immunogenicity, respectively. In order to overcome these limitations, a transdisiplinary regenerative engineering strategy has emerged with a focus on the development of biomimetic scaffolds that closely mimic the properties of the native tissues. For example, the structure of muscle tissue is characterized by oriented muscle fibers. However, fabrication of aligned nanofiber structures that mimic the anisotropic organization of muscle presents significant engineering challenges ...


Biological Implications Of Satellite Cells For Scaffold-Based Muscle Regenerative Engineering, Maggie R. Del Ponte, Charter Chain, Meng Deng Dr., Feng Yue Dr., Shihuan Kuang Dr. 2014 Purdue University

Biological Implications Of Satellite Cells For Scaffold-Based Muscle Regenerative Engineering, Maggie R. Del Ponte, Charter Chain, Meng Deng Dr., Feng Yue Dr., Shihuan Kuang Dr.

The Summer Undergraduate Research Fellowship (SURF) Symposium

Satellite cells are anatomically localized along the surface of muscle fibers and have been regarded as a population of muscle-specific progenitors that are responsible for muscle regeneration. In response to muscle injuries, satellite cells are activated to enter the cell cycle, then proliferate and differentiate into mature muscle cells to regenerate damaged myofibers. Unfortunately, this natural repair mechanism is interrupted in conditions such as muscle degenerative diseases or volumetric muscle loss. The function of stem cells is regulated by signals from their local microenvironment which is called the stem cell niche. Current satellite cell-based strategies such as direct cell transplantation ...


The Role Of Metal Oxide Layers In The Sensitivity Of Lactate Biosensors Subjected To Oxygen-Limited Conditions, Elizabeth Andreasen, Lia Stanciu, Aytekin Uzunoglu 2014 Purdue University

The Role Of Metal Oxide Layers In The Sensitivity Of Lactate Biosensors Subjected To Oxygen-Limited Conditions, Elizabeth Andreasen, Lia Stanciu, Aytekin Uzunoglu

The Summer Undergraduate Research Fellowship (SURF) Symposium


Amperometric lactate biosensors are used to detect lactate concentration in blood and tissues, which is integral in identifying cyanide poisoning, septic shock, and athletic condition. The construction of lactate biosensors with high sensitivity, selectivity, and stability is imperative to diagnose and determine these medical conditions. Lactate detection is currently limited to oxygen-rich environments due to the fact that oxygen is a limiting factor in the lactate reaction. To circumvent this problem, researchers have developed mediators or alternate, oxygen-free enzymes to improve sensitivity. In our study, ceria (CeO2) with high oxygen storage capacity (OSC) was introduced to the enzyme layer ...


Characterization Of Swelling Ratio And Water Content Of Hydrogels For Cartilage Engineering Applications, Emily E. Gill, Renay S.-C. Su, Julie C. Liu 2014 Purdue University

Characterization Of Swelling Ratio And Water Content Of Hydrogels For Cartilage Engineering Applications, Emily E. Gill, Renay S.-C. Su, Julie C. Liu

The Summer Undergraduate Research Fellowship (SURF) Symposium

Due to the high prevalence of arthritis and cartilage-related injuries, tissue engineers are studying ways to grow cartilage tissue replacements. Resilin, an elastomeric protein found in insect cuticles, is known for its extraordinary resilience and elasticity. In previous studies, recombinant resilin-based hydrogels, or cross-linked protein networks, exhibited potential for use in cartilage tissue scaffolds. Our lab successfully developed resilin-based proteins with a sequence based on the mosquito gene and showed that resilin-based hydrogels possess mechanical properties of the same order of magnitude as native articular cartilage. In addition, these mechanical properties can be controlled by changing the protein concentration. To ...


Surgical Adhesive From Mussel Mimetic Polymer, Jenna DeSousa, Cori Jenkins, Jonathan Wilker 2014 Purdue University

Surgical Adhesive From Mussel Mimetic Polymer, Jenna Desousa, Cori Jenkins, Jonathan Wilker

The Summer Undergraduate Research Fellowship (SURF) Symposium

Injuries involving damaged tissues are currently repaired through an invasive technique involving the use of screws, plates and sutures as support, which can damage these tissues. The biomedical field currently lacks an adhesive that can replace harmful implants. A surgical adhesive can provide a quick and easy alternative, which will minimize the risk of damaging healthy tissue in surgery. Inspiration for such materials can be found by looking at marine mussels as they are able to stick to nearly any surface, even in wet environments. Marine mussels affix themselves to different surfaces using adhesive plaques consisting of various proteins. Polymer ...


Material Transfer Controlled By Elastomeric Layer Thickness, Michael D. Bartlett, Alfred J. Crosby 2014 University of Massachusetts - Amherst

Material Transfer Controlled By Elastomeric Layer Thickness, Michael D. Bartlett, Alfred J. Crosby

Michael Bartlett

Transferring material components across substrates through the
control of interfacial adhesion is important for electronics, biology and
other fabrication processes. Here we show a transfer mechanism
which controls adhesive force through the thickness of supported
elastomeric substrates. This is experimentally demonstrated by
transferring millimeter and centimeter scale wafers to progressively
thinner substrates without any specific actuation, chemical treatment,
or surface topography. We extend this methodology by selectively
transferring objects with sub-surface patterns and demonstrate how
thickness control can enable roll-to-roll material transfer processes.
These experiments are supported by a theoretical model which
demonstrates how this mechanism is governed by the ...


Fabrication And Testing Of Arabinan Cellulose Nanocomposites, Ross Johnson, Austin Rosso, Nick Semansky 2014 California Polytechnic State University - San Luis Obispo

Fabrication And Testing Of Arabinan Cellulose Nanocomposites, Ross Johnson, Austin Rosso, Nick Semansky

Materials Engineering

Inspired by the structure and composition of cactus spines found in nature, arabinan-cellulose nanocomposites were fabricated into thin films and tested for mechanical stiffness. The composites consisted of varying amounts of nanocrystalline cellulose reinforcement suspended in an arabinan matrix. Both materials are polysaccharides and are known to be biodegradable and food safe. The thin film samples were tensile tested using a dynamic mechanical analysis machine both as-cast and after a heat-treatment. The heat treatment of the arabinan itself resulted in an order of magnitude increase in stiffness, while the cellulose reinforced composites increased roughly six fold. The arabinan-50 wt% cellulose ...


Developent Of A Phospholipid Encapsulation Process For Quantum Dots To Be Used In Biologic Applications, Logan Grimes 2014 California Polytechnic State University, San Luis Obispo

Developent Of A Phospholipid Encapsulation Process For Quantum Dots To Be Used In Biologic Applications, Logan Grimes

Master's Theses and Project Reports

The American Cancer Society predicts that 1,665,540 people will be diagnosed with cancer, and 585,720 people will die from cancer in 2014. One of the most common types of cancer in the United States is skin cancer. Melanoma alone is predicted to account for 10,000 of the cancer related deaths in 2014. As a highly mobile and aggressive form of cancer, melanoma is difficult to fight once it has metastasized through the body. Early detection in such varieties of cancer is critical in improving survival rates in afflicted patients. Present methods of detection rely on visual ...


Mixed Culture Electrochemically Active Biofilms And Their Microscopic And Spectroelectrochemical Studies, Mohammad Mansoob Khan Dr, S. A. Ansari, J. H. Lee, J. Lee, M. H. Cho 2014 Universiti Brunei Darussalaam

Mixed Culture Electrochemically Active Biofilms And Their Microscopic And Spectroelectrochemical Studies, Mohammad Mansoob Khan Dr, S. A. Ansari, J. H. Lee, J. Lee, M. H. Cho

Dr. Mohammad Mansoob Khan

Mixed culture electrochemically active biofilms (EABs) were developed on carbon paper using a sludge with mixed culture bacteria for microscopic and pectroelectrochemical studies because a naturally mixed culture bacterial strain is more applicable than a pure culture strain. EAB development was confirmed by microbial fuel cells (MFCs) by obtaining a constant increase in potential (∼0.36 V). Microscopic and spectroscopic studies showed that a mixed culture EABs formed on the support. Cyclic voltammetry (CV), differential pulse voltammetry (DPV), and electrochemical impedance spectroscopy (EIS), which are nondestructive voltammetry techniques, indicated that the EABs could be source of electrons and used effectively ...


Agen/Bsen 344: Biological And Environmental Transport Processes—A Peer Review Of Teaching Project Benchmark Portfolio, Shadi F. Othman 2014 University of Nebraska - Lincoln

Agen/Bsen 344: Biological And Environmental Transport Processes—A Peer Review Of Teaching Project Benchmark Portfolio, Shadi F. Othman

UNL Faculty Course Portfolios

The course I am providing a portfolio for is BSEN/AGEN 344 which is a required course for all our undergraduate students. The Department provides an assessment for the course to align itself with the ABET's Accreditation Process. I taught the course in Spring 2012 adapting a new Team Based Learning Approach. I have three main objective from my portfolio: (1) refine my methods in documenting the linkage between my course goals and assessment measures, (2) document the efficacy of team based learning approach, (3) refine team based learning approach for the current course and adapt the approach to ...


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