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Development Of Image-Based Surgical Planning Software For Bone-Conduction Implants, Carlos D. Salgado 2018 The University of Western Ontario

Development Of Image-Based Surgical Planning Software For Bone-Conduction Implants, Carlos D. Salgado

Electronic Thesis and Dissertation Repository

The BONEBRIDGE bone-conduction device is used to treat conductive and mixed hearing losses. The size of its floating mass transducer (FMT) can preclude implantation in certain anatomies, necessitating comprehensive surgical planning. Current techniques are time consuming and difficult to transfer to the operating room. The objective of this thesis was to develop software for calculating skull thickness to the dura mater to find locations for the FMT and to the first air cells which guarantee sufficient bone for the implant screws to grasp. Temporal bone computed tomography (CT) images were segmented and processed and custom Matlab code was written to ...


Development Of An Emg-Based Muscle Health Model For Elbow Trauma Patients, Emma Farago 2018 The University of Western Ontario

Development Of An Emg-Based Muscle Health Model For Elbow Trauma Patients, Emma Farago

Electronic Thesis and Dissertation Repository

Musculoskeletal (MSK) conditions are a leading cause of pain and disability worldwide. Rehabilitation is critical for recovery from these conditions and for the prevention of long-term disability. Robot-assisted therapy has been demonstrated to provide improvements to stroke rehabilitation in terms of efficiency and patient adherence. However, there are no wearable robot-assisted solutions for patients with MSK injuries. One of the limiting factors is the lack of appropriate models that allow the use of biosignals as an interface input. Furthermore, there are no models to discern the health of MSK patients as they progress through their therapy.

This thesis describes the ...


Shaped 3d Microcarriers For Adherent Cell Culture And Analysis, Chueh-Yu Wu, Daniel Stoecklein, Aditya Kommajosula, Jonathan Lin, Keegan Owsley, Baskar Ganapathysubramanian, Dino Di Carlo 2018 University of California, Los Angeles

Shaped 3d Microcarriers For Adherent Cell Culture And Analysis, Chueh-Yu Wu, Daniel Stoecklein, Aditya Kommajosula, Jonathan Lin, Keegan Owsley, Baskar Ganapathysubramanian, Dino Di Carlo

Mechanical Engineering Publications

Standard tissue culture of adherent cells is known to poorly replicate physiology and often entails suspending cells in solution for analysis and sorting, which modulates protein expression and eliminates intercellular connections. To allow adherent culture and processing in flow, we present 3D-shaped hydrogel cell microcarriers, which are designed with a recessed nook in a first dimension to provide a tunable shear-stress shelter for cell growth, and a dumbbell shape in an orthogonal direction to allow for self-alignment in a confined flow, important for processing in flow and imaging flow cytometry. We designed a method to rapidly design, using the genetic ...


Transcranial Magnetic Stimulation: Design Of A Stimulator And A Focused Coil For The Application Of Small Animals, Jayaprakash Selvaraj, Priyam Rastogi, Neelam G. Prabhu Gaunkar, Ravi L. Hadimani, Mani Mina 2018 Iowa State University

Transcranial Magnetic Stimulation: Design Of A Stimulator And A Focused Coil For The Application Of Small Animals, Jayaprakash Selvaraj, Priyam Rastogi, Neelam G. Prabhu Gaunkar, Ravi L. Hadimani, Mani Mina

Electrical and Computer Engineering Publications

Transcranial magnetic stimulation (TMS) is a non-invasive, safe, effective, and food and drug administration approved treatment for major depressive disorder. TMS relies on time-varying magnetic fields to induce an electric field in the brain, resulting in depolarization or hyperpolarization of the neurons. Recently, there has been extensive research to improve the magnetic coil design, effectiveness of TMS treatment, and improvement in the computer modeling of human brains, yet little development is reported on the TMS pulse generators and coil design for small animals. TMS pulse generators, or stimulators, are the circuits which provides pulse current to drive the inductive coils ...


New Algorithms For Compressed Sensing Of Mri: Wtwts, Dwts, Wdwts, Srivarna Settisara Janney 2018 Kennesaw State University

New Algorithms For Compressed Sensing Of Mri: Wtwts, Dwts, Wdwts, Srivarna Settisara Janney

Master of Science in Computer Science Theses

Magnetic resonance imaging (MRI) is one of the most accurate imaging techniques that can be used to detect several diseases, where other imaging methodologies fail. MRI data takes a longer time to capture. This is a pain taking process for the patients to remain still while the data is being captured. This is also hard for the doctor as well because if the images are not captured correctly then it will lead to wrong diagnoses of illness that might put the patients lives in danger. Since long scanning time is one of most serious drawback of the MRI modality, reducing ...


Optimization Of Gpu-Accelerated Iterative Ct Reconstruction Algorithm For Clinical Use, Tao Ge 2018 Washington University in St. Louis

Optimization Of Gpu-Accelerated Iterative Ct Reconstruction Algorithm For Clinical Use, Tao Ge

Engineering and Applied Science Theses & Dissertations

In order to transition the GPU-accelerated CT reconstruction algorithm to a more clinical environment, a graphical user interface is implemented. Some optimization methods on the implementation are presented. We describe the alternating minimization (AM) algorithm as the updating algorithm, and the branchless distance-driven method for the system forward operator. We introduce a version of the Feldkamp-Davis-Kress algorithm to generate the initial image for our alternating minimization algorithm and compare it to a choice of a constant initial image. For the sake of better rate of convergence, we introduce the ordered-subsets method, find the optimal number of ordered subsets, and discuss ...


Segmentation, Tracking, And Kinematics Of Lung Parenchyma And Lung Tumors From 4d Ct With Application To Radiation Treatment Planning., Jungwon Cha 2018 University of Louisville

Segmentation, Tracking, And Kinematics Of Lung Parenchyma And Lung Tumors From 4d Ct With Application To Radiation Treatment Planning., Jungwon Cha

Electronic Theses and Dissertations

This thesis is concerned with development of techniques for efficient computerized analysis of 4-D CT data. The goal is to have a highly automated approach to segmentation of the lung boundary and lung nodules inside the lung. The determination of exact lung tumor location over space and time by image segmentation is an essential step to track thoracic malignancies. Accurate image segmentation helps clinical experts examine the anatomy and structure and determine the disease progress. Since 4-D CT provides structural and anatomical information during tidal breathing, we use the same data to also measure mechanical properties related to deformation of ...


Longitudinal Tracking Of Physiological State With Electromyographic Signals., Robert Warren Stallard 2018 University of Louisville

Longitudinal Tracking Of Physiological State With Electromyographic Signals., Robert Warren Stallard

Electronic Theses and Dissertations

Electrophysiological measurements have been used in recent history to classify instantaneous physiological configurations, e.g., hand gestures. This work investigates the feasibility of working with changes in physiological configurations over time (i.e., longitudinally) using a variety of algorithms from the machine learning domain. We demonstrate a high degree of classification accuracy for a binary classification problem derived from electromyography measurements before and after a 35-day bedrest. The problem difficulty is increased with a more dynamic experiment testing for changes in astronaut sensorimotor performance by taking electromyography and force plate measurements before, during, and after a jump from a small ...


Phase Unwrapping Of 4d-Flow Mri Data With Graph Cuts., Andrew Justice 2018 University of Louisville

Phase Unwrapping Of 4d-Flow Mri Data With Graph Cuts., Andrew Justice

Electronic Theses and Dissertations

A common issue when measuring velocity utilizing 4D flow magnetic resonance imaging (MRI) is aliasing that occurs because of a low velocity encoding parameter (VENC). Aliasing can be avoided if the velocity encoding parameter is set above the largest velocity quantity. However, when this is done the velocity to noise ratio is lowered less detail is acquired in the image. Thusly, it is sometimes desirable to have a below the maximum velocity to acquire higher quality data.

Consequently, an efficient and robust algorithm is needed to unwrap the aliased data. This paper proposes an iterative graph cuts algorithm to perform ...


Image Processing Applications In Real Life: 2d Fragmented Image And Document Reassembly And Frequency Division Multiplexed Imaging, Houman Kamran Habibkhani, Houman Kamran Habibkhani 2018 Louisiana State University

Image Processing Applications In Real Life: 2d Fragmented Image And Document Reassembly And Frequency Division Multiplexed Imaging, Houman Kamran Habibkhani, Houman Kamran Habibkhani

LSU Doctoral Dissertations

In this era of modern technology, image processing is one the most studied disciplines of signal processing and its applications can be found in every aspect of our daily life. In this work three main applications for image processing has been studied.

In chapter 1, frequency division multiplexed imaging (FDMI), a novel idea in the field of computational photography, has been introduced. Using FDMI, multiple images are captured simultaneously in a single shot and can later be extracted from the multiplexed image. This is achieved by spatially modulating the images so that they are placed at different locations in the ...


Generalized Robust Mtl Semantics For Problems In Cardiac Electrophysiology, Houssam Abbas, Rahul Mangharam 2018 University of Pennsylvania

Generalized Robust Mtl Semantics For Problems In Cardiac Electrophysiology, Houssam Abbas, Rahul Mangharam

Real-Time and Embedded Systems Lab (mLAB)

Robustness-Guided Falsification (RGF) is an efficient

testing technique that tries to find a system execution that

violates some formal specification, by minimizing the robustness

of the specification over the set of initial conditions of the

system. Robustness uses an underlying distance function on

the space of system executions. As RGF is applied to new fields

like medicine, it is essential to determine whether our distances

still capture the domain expert’s intuition of which executions

are similar and which are not. Motivated by the problem of

testing the algorithms of cardiac defibrillators implanted in

millions of patients worldwide, this work ...


Deep Gaze Velocity Analysis During Mammographic Reading For Biometric Identification Of Radiologists, Hong-Jun Yoon, Folami Alamudun, Kathy Hudson, Garnetta Morin-Ducote, Georgia Tourassi 2018 Biomedical Sciences, Engineering, and Computing Group Health Data Sciences Institute, Oak Ridge National Laboratory

Deep Gaze Velocity Analysis During Mammographic Reading For Biometric Identification Of Radiologists, Hong-Jun Yoon, Folami Alamudun, Kathy Hudson, Garnetta Morin-Ducote, Georgia Tourassi

Journal of Human Performance in Extreme Environments

Several studies have confirmed that the gaze velocity of the human eye can be utilized as a behavioral biometric or personalized biomarker. In this study, we leverage the local feature representation capacity of convolutional neural networks (CNNs) for eye gaze velocity analysis as the basis for biometric identification of radiologists performing breast cancer screening. Using gaze data collected from 10 radiologists reading 100 mammograms of various diagnoses, we compared the performance of a CNN-based classification algorithm with two deep learning classifiers, deep neural network and deep belief network, and a previously presented hidden Markov model classifier. The study showed that ...


Plasmonic Nanoplatforms For Biochemical Sensing And Medical Applications, Arash Ahmadivand 2018 Florida International University

Plasmonic Nanoplatforms For Biochemical Sensing And Medical Applications, Arash Ahmadivand

FIU Electronic Theses and Dissertations

Plasmonics, the science of the excitation of surface plasmon polaritons (SPP) at the metal-dielectric interface under intense beam radiation, has been studied for its immense potential for developing numerous nanophotonic devices, optical circuits and lab-on-a-chip devices. The key feature, which makes the plasmonic structures promising is the ability to support strong resonances with different behaviors and tunable localized hotspots, excitable in a wide spectral range. Therefore, the fundamental understanding of light-matter interactions at subwavelength nanostructures and use of this understanding to tailor plasmonic nanostructures with the ability to sustain high-quality tunable resonant modes are essential toward the realization of highly ...


Big Data And Parkinson’S Disease: Exploration, Analyses, And Data Challenges, Mahalakshmi SenthilarumugamVeilukandammal, Sree Nilakanta, Baskar Ganapathysubramanian, Vellareddy Anantharam, Anumantha Kanthasamy, Auriel A. Willette 2018 Iowa State University

Big Data And Parkinson’S Disease: Exploration, Analyses, And Data Challenges, Mahalakshmi Senthilarumugamveilukandammal, Sree Nilakanta, Baskar Ganapathysubramanian, Vellareddy Anantharam, Anumantha Kanthasamy, Auriel A. Willette

Mechanical Engineering Conference Presentations, Papers, and Proceedings

In healthcare, a tremendous amount of clinical and laboratory tests, imaging, prescription and medication data are being collected. Big data analytics on these data aim at early detection of disease which will help in developing preventive measures and in improving patient care. Parkinson disease is the second-most common neurodegenerative disorder in the United States. To find a cure for Parkinson's disease biological, clinical and behavioral data of different cohorts are collected, managed and propagated through Parkinson’s Progression Markers Initiative (PPMI). Applying big data technology to this data will lead to the identification of the potential biomarkers of Parkinson ...


Transfer Operator Theoretic Framework For Monitoring Building Indoor Environment In Uncertain Operating Conditions, Himanshu Sharma, Anthony D. Fontanini, Umesh Vaidya, Baskar Ganapathysubramanian 2018 Iowa State University

Transfer Operator Theoretic Framework For Monitoring Building Indoor Environment In Uncertain Operating Conditions, Himanshu Sharma, Anthony D. Fontanini, Umesh Vaidya, Baskar Ganapathysubramanian

Mechanical Engineering Publications

Dynamical system-based linear transfer Perron- Frobenius (P-F) operator framework is developed to address analysis and design problems in the building system. In particular, the problems of fast contaminant propagation and optimal placement of sensors in uncertain operating conditions of indoor building environment are addressed. The linear nature of transfer P-F operator is exploited to develop a computationally efficient numerical scheme based on the finite dimensional approximation of P-F operator for fast propagation of contaminants. The proposed scheme is an order of magnitude faster than existing methods that rely on simulation of an advection-diffusion partial differential equation for contaminant transport. Furthermore ...


Brain Science = Biology + Engineering, Jennifer Welborn, Guangyu Xu, Morton Sternheim, Chris Emery 2018 Amherst Regional Middle School

Brain Science = Biology + Engineering, Jennifer Welborn, Guangyu Xu, Morton Sternheim, Chris Emery

Science and Engineering Saturday Seminars

This interdisciplinary (physical and life sciences) seminar exposes participants to cutting edge research at UMASS, Amherst, on cell imaging using a chip which gathers a variety of data on the activities of single cells. Part of the seminar will be a presentation of current research in this area, followed by hands-on activities and a visit to the lab where this research is conducted. Application of this new technology to brain research will be discussed as well as the NGSS standards alignment and classroom applications at various levels and disciplines.


Investigation Of Shape, Position, And Permeability Of Shielding Material In Quadruple Butterfly Coil For Focused Transcranial Magnetic Stimulation, Priyam Rastogi, Bowen Zhang, Yalun Tang, Erik G. Lee, Ravi L. Hadimani, David C. Jiles 2018 Iowa State University

Investigation Of Shape, Position, And Permeability Of Shielding Material In Quadruple Butterfly Coil For Focused Transcranial Magnetic Stimulation, Priyam Rastogi, Bowen Zhang, Yalun Tang, Erik G. Lee, Ravi L. Hadimani, David C. Jiles

Electrical and Computer Engineering Publications

Transcranial magnetic stimulation has been gaining popularity in the therapy for several neurological disorders. A time-varying magnetic field is used to generate electric field in the brain. As the development of TMS methods takes place, emphasis on the coil design increases in order to improve focal stimulation. Ideally reduction of stimulation of neighboring regions of the target area is desired. This study, focused on the improvement of the focality of the Quadruple Butterfly Coil (QBC) with supplemental use of different passive shields. Parameters such as shape, position and permeability of the shields have been explored to improve the focus of ...


Development Of A Novel Anti-Infectivity Platform For The Treatment Of Neglected Tropical And Infectious Diseases, Andrea Marie Binnebose 2018 Iowa State University

Development Of A Novel Anti-Infectivity Platform For The Treatment Of Neglected Tropical And Infectious Diseases, Andrea Marie Binnebose

Graduate Theses and Dissertations

This dissertation focuses on the design of novel strategies for the prevention and treatment of neglected tropical and infectious diseases using polyanhydride nanoparticles as a drug delivery platform. The overall goal of this research is to design efficacious drug delivery vehicles that are effective against the filarial nematode Brugia malayi and B. pahangi and intracellular bacteria Mycobacterium tuberculosis, M. paratuberculosis, and M. marinum. The primary goal is to use the polyanhydride nanoparticles to deliver high enough microenvironmental concentrations to cause the death of the organism, thereby reducing the mortality, morbidity, and transmission of the disease. While a wide array of ...


Excitation And Injury Of Adult Ventricular Cardiomyocytes By Nano- To Millisecond Electric Shocks, Iurii Semenov, Sergey Grigoryev, Johanna U. Neuber, Christian W. Zemlin, Olga N. Pakhomova, Maura Casciola, Andrei G. Pakhomov 2018 Old Dominion University

Excitation And Injury Of Adult Ventricular Cardiomyocytes By Nano- To Millisecond Electric Shocks, Iurii Semenov, Sergey Grigoryev, Johanna U. Neuber, Christian W. Zemlin, Olga N. Pakhomova, Maura Casciola, Andrei G. Pakhomov

Bioelectrics Publications

Intense electric shocks of nanosecond (ns) duration can become a new modality for more efficient but safer defibrillation. We extended strength-duration curves for excitation of cardiomyocytes down to 200 ns, and compared electroporative damage by proportionally more intense shocks of different duration. Enzymatically isolated murine, rabbit, and swine adult ventricular cardiomyocytes (VCM) were loaded with a Ca2+ indicator Fluo-4 or Fluo-5N and subjected to shocks of increasing amplitude until a Ca2+ transient was optically detected. Then, the voltage was increased 5-fold, and the electric cell injury was quantified by the uptake of a membrane permeability marker dye, propidium ...


Upregulation Of Dna Sensors In B16.F10 Melanoma Spheroid Cells After Electrotransfer Of Pdna, Katarina Znidar, Masa Bosnjak, Tanja Jesenko, Loree C. Heller, Maja Cemazar 2018 Old Dominion University

Upregulation Of Dna Sensors In B16.F10 Melanoma Spheroid Cells After Electrotransfer Of Pdna, Katarina Znidar, Masa Bosnjak, Tanja Jesenko, Loree C. Heller, Maja Cemazar

Bioelectrics Publications

Increased expression of cytosolic DNA sensors, a category of pattern recognition receptor, after control plasmid DNA electrotransfer was observed in our previous studies on B16.F10 murine melanoma cells. This expression was correlated with the upregulation of proinflammatory cytokines and chemokines and was associated with cell death. Here, we expanded our research to include the influence of features of cells in a 3-dimensional environment, which better represents the tumors’ organization in vivo. Our results show that lower number of cells were transfected in spheroids compared to 2-dimensional cultures, that growth was delayed after electroporation alone or after electrotransfer of plasmid ...


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