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A Stroke Therapy Brace Design, Evan Kirkbride 2016 California Polytechnic State University, San Luis Obispo

A Stroke Therapy Brace Design, Evan Kirkbride

Electrical Engineering

Victims of stroke often have difficulty with rehabilitation. With limited movement on their affected arm, patients often do not want to move much for physical therapy. In this project, we design a robotic brace that helps stroke patients move their arm more effectively in a reaching or pulling motion. By giving patients more movement in their affected arm than they would have otherwise, patients gain more from rehabilitation. The brace also adapts to the patient’s needs, providing more inclination or resistance as needed for their physical therapy. This kind of therapy engages patients rather than relying on their likely ...


Improving Radiation Therapy Through Motion Tracking, Hanlin Wan 2016 Washington University in St. Louis

Improving Radiation Therapy Through Motion Tracking, Hanlin Wan

Engineering and Applied Science Theses & Dissertations

Radiation therapy is a widely-used cancer treatment method in which lethal doses of ionizing radiation are delivered to cancerous cells. Given the high dose requirements and the risk of associated complications, it is essential that radiation be targeted to cancerous cells while minimizing the dose to surrounding tissue. While current technology allows for accurate targeting of radiation dose, there is one major hurdle: Respiratory motion causes movement of up to a few centimeters of tumors in the abdomen and thorax, rendering even the most accurate radiation delivery machine highly inaccurate. Imaging devices integrated with the treatment machines allow us to ...


Translational Photoacoustic Tomography, Yong Zhou 2016 Washington University in St. Louis

Translational Photoacoustic Tomography, Yong Zhou

Engineering and Applied Science Theses & Dissertations

Combining optical excitation and ultrasonic detection, photoacoustic tomography (PAT) offers deep imaging with high resolution. With optical excitation, PAT maintains the high contrast of optical imaging. Because of the low scattering of ultrasonic waves in tissue, PAT achieves high spatial resolution at depths. Several advantages make PAT suitable for clinical application, including its scalable penetration and resolution, high optical absorption contrast, fast imaging speed, and ability to perform spectral decomposition. Based on different image reconstruction mechanisms, PAT can be further divided into two embodiments: raster-scanning-based photoacoustic microscopy (PAM) and reconstruction-algorism-based photoacoustic computed tomography (PACT). This dissertation aims to advance the ...


Design And Implementation Of An Integrated Biosensor Platform For Lab-On-A-Chip Diabetic Care Systems, Khandaker Abdullah Al Mamun 2016 University of Tennessee - Knoxville

Design And Implementation Of An Integrated Biosensor Platform For Lab-On-A-Chip Diabetic Care Systems, Khandaker Abdullah Al Mamun

Doctoral Dissertations

Recent advances in semiconductor processing and microfabrication techniques allow the implementation of complex microstructures in a single platform or lab on chip. These devices require fewer samples, allow lightweight implementation, and offer high sensitivities. However, the use of these microstructures place stringent performance constraints on sensor readout architecture. In glucose sensing for diabetic patients, portable handheld devices are common, and have demonstrated significant performance improvement over the last decade. Fluctuations in glucose levels with patient physiological conditions are highly unpredictable and glucose monitors often require complex control algorithms along with dynamic physiological data. Recent research has focused on long term ...


Modeling Mortality Data: A Case Study In Data Management For Computer Science Research, Anna Newman 2016 Simmons College, Graduate School of Library & Information Science

Modeling Mortality Data: A Case Study In Data Management For Computer Science Research, Anna Newman

University of Massachusetts and New England Area Librarian e-Science Symposium

This poster presents the results of a case study completed as part of the Simmons College course Scientific Research Data Management. The case study focuses on research conducted by a computer science laboratory on factors that influence patient mortality, using topic modeling and other computational techniques. Based on the research narrative, data management practices and needs specific to computer science research are mapped to the New England Collaborative Data Management Curriculum Modules for Managing Research Data. These areas of focus will help information professionals to identify the data management challenges presented by computer science research, as well as the tools ...


Deformable Contour Models For Digitizing A Printed Brainstem Atlas, Nirmal J. Patel 2016 Old Dominion University

Deformable Contour Models For Digitizing A Printed Brainstem Atlas, Nirmal J. Patel

Electrical & Computer Engineering Theses & Disssertations

The brainstem is a part of the brain that is connected to the cerebrum and the spinal cord. Ten out of twelve pairs of cranial nerves emerge from the brainstem. The cranial nerves transmit information between the brain and various parts of the body. Due to its anatomical and physiological relevance, a descriptive digital brainstem is important for neurosurgery planning and simulation. For both of these neurosurgical applications, the complexity of the brainstem requires a digital atlas approach to segmentation that maps intensities to tissues rather than less descriptive voxel or surface-based approaches. However, a descriptive brainstem atlas with adequate ...


Utilizing Brain-Computer Interfacing To Control Neuroprosthetic Devices, Cheyne J. Angy 2016 Liberty University

Utilizing Brain-Computer Interfacing To Control Neuroprosthetic Devices, Cheyne J. Angy

Senior Honors Theses

Advances in neuroprosthetics in recent years have made an enormous impact on the quality of life for many people with disabilities, helping them regain the functionality of damaged or impaired abilities. One of the main hurdles to regaining full functionality regarding neuroprosthetics is the integration between the neural prosthetic device and the method in which the neural prosthetic device is controlled or manipulated to function correctly and efficiently. One of the most promising methods for integrating neural prosthetics to an efficient method of control is through Brian-computer Interfacing (BCI). With this method, the neuroprosthetic device is integrated into the human ...


Blind X-Ray Ct Image Reconstruction From Polychromatic Poisson Measurements, Renliang Gu, Aleksandar Dogandžić 2016 Iowa State University

Blind X-Ray Ct Image Reconstruction From Polychromatic Poisson Measurements, Renliang Gu, Aleksandar Dogandžić

Electrical and Computer Engineering Publications

We develop a framework for reconstructing images that are sparse in an appropriate transform domain from polychromatic computed tomography (CT) measurements under the blind scenario where the material of the inspected object and incident-energy spectrum are unknown. Assuming that the object that we wish to reconstruct consists of a single material, we obtain a parsimonious measurement-model parameterization by changing the integral variable from photon energy to mass attenuation, which allows us to combine the variations brought by the unknown incident spectrum and mass attenuation into a single unknown mass-attenuation spectrum function; the resulting measurement equation has the Laplaceintegral form. The ...


Design Of Highly Stable Low-Density Self-Assembled Monolayers Using Thiol-Yne Click Reaction For The Study Of Protein-Surface Interactions, Leila Safazadeh Haghighi 2016 University of Kentucky

Design Of Highly Stable Low-Density Self-Assembled Monolayers Using Thiol-Yne Click Reaction For The Study Of Protein-Surface Interactions, Leila Safazadeh Haghighi

Theses and Dissertations--Chemical and Materials Engineering

Protein adsorption on solid surfaces is a common yet complicated phenomenon that is not fully understood. Self-assembled monolayers have been utilized in many studies, as well-defined model systems for studying protein-surface interactions in the atomic level. Various strategies, including the use of single component SAMs[1, 2], combinations of long and short alkanethiolates with methyl- and hydroxyl- terminal groups[3, 4], and using mixtures of alkanethiolates with similar chain length and varying terminal functional group [5] have been used to effectively control the surface wettability and determine the effect of surface composition and wettability on protein adsorption. In this dissertation ...


Enhancing Nerve Regeneration In The Peripheral Nervous System Using Polymeric Scaffolds, Stem Cell Engineering And Nanoparticle Delivery System, Anup Dutt Sharma 2016 Iowa State University

Enhancing Nerve Regeneration In The Peripheral Nervous System Using Polymeric Scaffolds, Stem Cell Engineering And Nanoparticle Delivery System, Anup Dutt Sharma

Graduate Theses and Dissertations

Peripheral nerve regeneration is a complex biological process responsible for regrowth of neural tissue following a nerve injury. The main objective of this project was to enhance peripheral nerve regeneration using interdisciplinary approaches involving polymeric scaffolds, stem cell therapy, drug delivery and high content screening. Biocompatible and biodegradable polymeric materials such as poly (lactic acid) were used for engineering conduits with micropatterns capable of providing mechanical support and orientation to the regenerating axons and polyanhydrides for fabricating nano/microparticles for localized delivery of neurotrophic growth factors and cytokines at the site of injury. Transdifferentiated bone marrow stromal cells or mesenchymal ...


Point Of Care Diagnostics And Health Monitoring Devices, Akshaya Shanmugam 2016 University of Massachusetts - Amherst

Point Of Care Diagnostics And Health Monitoring Devices, Akshaya Shanmugam

Doctoral Dissertations May 2014 - current

Existing disease screening methods mostly rely on symptom based diagnosis. This is mainly because of lack of accessibility and cost associated with the tests. Testing for the presence of the disease after the onset of symptoms has a negative impact on chances of survival and treatment costs.

Miniaturized low cost diagnostic devices that can be used outside the hospital setting can provide continuous health monitoring and aid in early diagnosis. This thesis presents techniques to develop such disease screening and health monitoring devices. The techniques presented here focus on medical devices that can benefit from microfluidic devices, fluorescence imaging, and ...


Biomolecules That Impact Phenotypic Transitions In Fibroblasts And Macrophages, Kiva Diane Forsmark 2016 Iowa State University

Biomolecules That Impact Phenotypic Transitions In Fibroblasts And Macrophages, Kiva Diane Forsmark

Graduate Theses and Dissertations

Macrophages and fibroblasts are intricately involved in many biological responses. The foreign body response (FBR) is orchestrated by macrophages, wherein the phenotypes of these macrophages exist plastically along a spectrum from M1, proinflammatory macrophages to M2a, anti-inflammatory, pro-wound healing macrophages, and M2c, regulatory macrophages. The timely progression of macrophages through these phenotypic changes is necessary for the resolution of this response. Interplay between M2a macrophages, myofibroblasts and M2c macrophages is responsible for the eventual resolution of this response. Following, transforming growth factor-β (TGF-β) activation, fibroblasts differentiate into myofibroblasts; these cells will secrete and contract extracellular matrix (ECM) components into a ...


Analysis Of Trans-Epithelial Electrical Resistance (Teer) In Organ-On-Chips To Study The Functions Of Human Placenta, Rajeendra Lakruwan Pemathilaka 2016 Iowa State University

Analysis Of Trans-Epithelial Electrical Resistance (Teer) In Organ-On-Chips To Study The Functions Of Human Placenta, Rajeendra Lakruwan Pemathilaka

Graduate Theses and Dissertations

Organ-on a-chip technology is becoming a popular method for drug testing. Microfluidic Organ-on-a-chip eliminates the need for live objects, such as animals, to do drug testing. Although the Organ-on-a-chip devices are becoming popular, creating a microfluidic device to represent human placenta is more challenging than other organs. Current drug testing methods are considered unethical and unreliable due to drug testing on animals and cost. The human placenta is a temporary organ created during pregnancy to connect fetus and its mother to allow nutrient supply, gas exchange, waste elimination, and avoid internal infections. Researchers wanted to study how the two-way traffic ...


In-Shoe Plantar Pressure System To Investigate Ground Reaction Force Using Android Platform, Ahmed A. Mostfa 2016 Virginia Commonwealth University

In-Shoe Plantar Pressure System To Investigate Ground Reaction Force Using Android Platform, Ahmed A. Mostfa

Theses and Dissertations

Human footwear is not yet designed to optimally relieve pressure on the heel of the foot. Proper foot pressure assessment requires personal training and measurements by specialized machinery. This research aims to investigate and hypothesize about Preferred Transition Speed (PTS) and to classify the gait phase of explicit variances in walking patterns between different subjects. An in-shoe wearable pressure system using Android application was developed to investigate walking patterns and collect data on Activities of Daily Living (ADL). In-shoe circuitry used Flexi-Force A201 sensors placed at three major areas: heel contact, 1st metatarsal, and 5th metatarsal with a PIC16F688 microcontroller ...


Assessment Of Optimized Electrode Configuration In Electrical Impedance Myography Study Using Genetic Algorithm Via Finite Element Model, Somen Baidya 2016 Georgia Southern University

Assessment Of Optimized Electrode Configuration In Electrical Impedance Myography Study Using Genetic Algorithm Via Finite Element Model, Somen Baidya

Electronic Theses & Dissertations

Electrical Impedance Myography (EIM) is a neurophysiologic technique in which high- frequency, low-intensity electrical current is applied via surface electrodes over a muscle or muscle group of interest and the resulting electrical parameters (resistance, reactance and phase) are analyzed to isolate diseased muscles from healthy ones. Beside muscle properties, some other anatomic and non-anatomic factors like muscle shape, subcutaneous fat (SF) thickness, inter-electrode distance, etc. also impact the major EIM parameters and thus affect the EIM analysis outcomes. The purpose of this study is to explore the effects of variation in some of these factors impose on EIM parameters and ...


Emlighten, Emily Mulvany 2016 University of Akron

Emlighten, Emily Mulvany

Honors Research Projects

This project is focused on creating a system to increase patient satisfaction in hospitals. My senior design team has been working hand in hand with the emergency department of Akron General to design this system called EMlighten. The goal is to create an experience for patients where they exit the hospital feeling more satisfied than they currently are. Patient satisfaction is a key performance indicator used by many hospitals to determine how much additional funding each hospital department is granted. If patients feel more satisfied, not only is that indicative of better care, but departments will receive extra funding. EMlighten ...


A Software Application For Cardiac-Gated Computerized Tomography Scanning, Stephen Caldwell, Trevor Engelsman 2016 University of Akron

A Software Application For Cardiac-Gated Computerized Tomography Scanning, Stephen Caldwell, Trevor Engelsman

Honors Research Projects

Computerized tomography (CT) scans are a common clinical imaging procedure used worldwide. Operating in the X-Ray spectrum, these machines rotate scanners around a stationary body in order to compile two-dimensional images into a unified three-dimensional image. With adjustment to scan frequency and intensity, internal features such as muscles, organs, and tendons can easily be viewed. However, the heart has long evaded CT use due to its near-constant motion. Recently, cardiac-gated scans have entered the market as a technique to image the heart at a specific moment in time when it is nearly still - the quiescent period. Occurring during rapid depolarization ...


Cobalt Ferrite Nanoparticles Fabricated Via Co-Precipitation In Air: Overview Of Size Control And Magnetic Properties, Dennis Toledo 2015 Florida International University

Cobalt Ferrite Nanoparticles Fabricated Via Co-Precipitation In Air: Overview Of Size Control And Magnetic Properties, Dennis Toledo

FIU Electronic Theses and Dissertations

Cobalt Ferrite has important, size-dependent magnetic properties. Consequently, an overview of particle size is important. Co-precipitation in air was the fabrication method used because it is comparatively simple and safe. The effects of three different reaction times including 1, 2, 3 hour(s) on particle size were compared. Also, the effectiveness of three different capping agents (Oleic Acid, Polyvinylpyrollidone (PVP), and Trisodium Citrate) in reducing aggregation and correspondingly particle size were examined. Using Welch’s analysis of variance (ANOVA) and the relevant post hoc tests, there was no significant difference (p=0.05) between reaction times of 1 hour and ...


Projected Nesterov’S Proximal-Gradient Signal Recovery From Compressive Poisson Measurements, Renliang Gu, Aleksandar Dogandžić 2015 Iowa State University

Projected Nesterov’S Proximal-Gradient Signal Recovery From Compressive Poisson Measurements, Renliang Gu, Aleksandar Dogandžić

Aleksandar Dogandžić

We develop a projected Nesterov’s proximal-gradient (PNPG) scheme for reconstructing sparse signals from compressive Poisson-distributed measurements with the mean signal intensity that follows an affine model with known intercept. The objective function to be minimized is a sum of convex data fidelity (negative log-likelihood (NLL)) and regularization terms. We apply sparse signal regularization where the signal belongs to a nonempty closed convex set within the domain of the NLL and signal sparsity is imposed using total-variation (TV) penalty. We present analytical upper bounds on the regularization tuning constant. The proposed PNPG method employs projected Nesterov’s acceleration step, function ...


Computational Characterization Of Exogenous Micrornas That Can Be Transferred Into Human Circulation, Jiang Shu, Kevin Chiang, Janos Zempleni, Juan Cui 2015 University of Nebraska-Lincoln

Computational Characterization Of Exogenous Micrornas That Can Be Transferred Into Human Circulation, Jiang Shu, Kevin Chiang, Janos Zempleni, Juan Cui

CSE Journal Articles

MicroRNAs have been long considered synthesized endogenously until very recent discoveries showing that human can absorb dietary microRNAs from animal and plant origins while the mechanism remains unknown. Compelling evidences of microRNAs from rice, milk, and honeysuckle transported to human blood and tissues have created a high volume of interests in the fundamental questions that which and how exogenous microRNAs can be transferred into human circulation and possibly exert functions in humans. Here we present an integrated genomics and computational analysis to study the potential deciding features of transportable microRNAs. Specifically, we analyzed all publicly available microRNAs, a total of ...


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