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The Electrophysiology Of Resting State Fmri Networks, Carl David Hacker 2017 Washington University in St. Louis

The Electrophysiology Of Resting State Fmri Networks, Carl David Hacker

Engineering and Applied Science Theses & Dissertations

Traditional research in neuroscience has studied the topography of specific brain functions largely by presenting stimuli or imposing tasks and measuring evoked brain activity. This paradigm has dominated neuroscience for 50 years. Recently, investigations of brain activity in the resting state, most frequently using functional magnetic resonance imaging (fMRI), have revealed spontaneous correlations within widely distributed brain regions known as resting state networks (RSNs). Variability in RSNs across individuals has found to systematically relate to numerous diseases as well as differences in cognitive performance within specific domains. However, the relationship between spontaneous fMRI activity and the underlying neurophysiology is not ...


Pet/Mr Imaging Of Hypoxic Atherosclerotic Plaque Using 64cu-Atsm, Xingyu Nie 2017 Washington University in St. Louis

Pet/Mr Imaging Of Hypoxic Atherosclerotic Plaque Using 64cu-Atsm, Xingyu Nie

Engineering and Applied Science Theses & Dissertations

ABSTRACT OF THE DISSERTATION

PET/MR Imaging of Hypoxic Atherosclerotic Plaque Using 64Cu-ATSM

by

Xingyu Nie

Doctor of Philosophy in Biomedical Engineering

Washington University in St. Louis, 2017

Professor Pamela K. Woodard, Chair

Professor Suzanne Lapi, Co-Chair

It is important to accurately identify the factors involved in the progression of atherosclerosis because advanced atherosclerotic lesions are prone to rupture, leading to disability or death. Hypoxic areas have been known to be present in human atherosclerotic lesions, and lesion progression is associated with the formation of lipid-loaded macrophages and increased local inflammation which are potential major factors in the formation of ...


An Exact Analysis For Four-Order Acousto-Optic Bragg Diffraction Which Incorporates Both Incident Light Angle And Sound Frequency Dependencies, Adeyinka Sunday Ademola 2017 University of Texas at Tyler

An Exact Analysis For Four-Order Acousto-Optic Bragg Diffraction Which Incorporates Both Incident Light Angle And Sound Frequency Dependencies, Adeyinka Sunday Ademola

Electrical Engineering Theses

This thesis extends the prior work which produced an exact solution to the four-order acousto-optic (AO) Bragg cell with assumed fixed center frequency and with exact Bragg angle incident light. The extension predicts the model that incorporates the dependencies of both the input angle of light and the sound frequency. Specifically, a generalized 4th order linear differential equation (DE), is developed from a simultaneous analysis of four coupled AO system of DEs. Through standard methods, the characteristic roots, which requires solving a quartic equation, is produced. Subsequently, a derived system of homogeneous solutions, which absorbs the roots obtained using ...


Development Of An Oxygen Saturation Monitoring System By Embedded Electronics, Manikandan Venkatesan Gomathy 2017 University of Arkansas, Fayetteville

Development Of An Oxygen Saturation Monitoring System By Embedded Electronics, Manikandan Venkatesan Gomathy

Theses and Dissertations

Measuring Oxygenation of blood (SaO2) plays a vital role in patient’s health monitoring. This is often measured by pulse oximeter, which is standard measure during anesthesia, asthma, operative and post-operative recoveries. Despite all, monitoring Oxygen level is necessary for infants with respiratory problems, old people, and pregnant women and in other critical situations.

This paper discusses the process of calculating the level of oxygen in blood and heart-rate detection using a non-invasive photo plethysmography also called as pulsoximeter using the MSP430FG437 microcontroller (MCU). The probe uses infrared lights to measure and should be in physical contact with any peripheral ...


Basic Science To Clinical Research: Segmentation Of Ultrasound And Modelling In Clinical Informatics, Ali K. Hamou 2017 The University of Western Ontario

Basic Science To Clinical Research: Segmentation Of Ultrasound And Modelling In Clinical Informatics, Ali K. Hamou

Electronic Thesis and Dissertation Repository

The world of basic science is a world of minutia; it boils down to improving even a fraction of a percent over the baseline standard. It is a domain of peer reviewed fractions of seconds and the world of squeezing every last ounce of efficiency from a processor, a storage medium, or an algorithm. The field of health data is based on extracting knowledge from segments of data that may improve some clinical process or practice guideline to improve the time and quality of care. Clinical informatics and knowledge translation provide this information in order to reveal insights to the ...


Advanced Signal Processing Methods For Plane-Wave Color Doppler Ultrasound Imaging, Omar Mansour 2017 The University of Western Ontario

Advanced Signal Processing Methods For Plane-Wave Color Doppler Ultrasound Imaging, Omar Mansour

Electronic Thesis and Dissertation Repository

Conventional medical ultrasound imaging uses focused beams to scan the imaging scene line-by-line, but recently however, plane-wave imaging, in which plane-waves are used to illuminate the entire imaging scene, has been gaining popularity due its ability to achieve high frame rates, thus allowing the capture of fast dynamic events and producing continuous Doppler data. In most implementations, multiple low-resolution images from different plane wave tilt angles are coherently averaged (compounded) to form a single high-resolution image, albeit with the undesirable side effect of reducing the frame rate, and attenuating signals with high Doppler shifts.

This thesis introduces a spread-spectrum color ...


Meta!Blast: A Serious Game To Explore The Complexities Of Structural And Metabolic Cell Biology, Eve S. Wurtele, Diane C. Bassham, Julie Dickerson, David J. Kabala, William Schneller, Mark Stenerson, Achyuthan Vasanth 2017 Iowa State University

Meta!Blast: A Serious Game To Explore The Complexities Of Structural And Metabolic Cell Biology, Eve S. Wurtele, Diane C. Bassham, Julie Dickerson, David J. Kabala, William Schneller, Mark Stenerson, Achyuthan Vasanth

Diane Bassham

Knowledge of cellular structure and function has increased dramatically with the advent of modern molecular and computational technologies. Helping students to understand cellular dynamics is a major challenge to educators. To address this challenge, we have developed the Kabala Engine, an open source engine based on OpenSG (http://www.opensg.org) and VRJuggler (http://www.vrjuggler.org). This engine is designed to enable biologists, and indeed any domain expert — chemists, artists, psychologists — to create virtual interactive worlds for teaching or research. As a proof-of-concept, we have used this engine to create Meta!Blast, a virtual plant cell containing a prototype ...


Silent Communication Device, Christopher Wayne Schutter 2017 Calfornia Polytechnic State University - San Luis Obispo

Silent Communication Device, Christopher Wayne Schutter

Master's Theses and Project Reports

Oral communication has constituted as a necessary aspect of how people interact with one another, but there are always situations where this form of communication can create distractions, irritation, or even danger. Take for example, a student in a laboratory who needs to communicate effectively with a lab partner without creating a distraction to those trying to work around said student or a soldier on a battlefield who needs to relay information effectively to his or her comrades without revealing his or her position to the enemy. It becomes apparent that people need a more exclusive form of communication in ...


Metablast! Virtual Cell: A Pedagogical Convergence Between Game Design And Science Education, Anson B. Call, Steven Herrnstadt, Eve S. Wurtele, Julie Dickerson, Diane Bassham 2017 Iowa State University

Metablast! Virtual Cell: A Pedagogical Convergence Between Game Design And Science Education, Anson B. Call, Steven Herrnstadt, Eve S. Wurtele, Julie Dickerson, Diane Bassham

Eve Wurtele

MetaBlast! Virtual Cell (from now on referred to as VC) is a game design solution to a specific scientific and educational problem; expressly, how to make advanced, university level plant biology instruction on molecular and anatomical levels an exciting, efficient learning experience. The advanced technologies of 3D modeling and animation, computer programming and game design are united and tempered with strong, scientific guidance for accuracy and art direction for a powerful visual and audio simulation. The additional strength of intense gaming as a powerful tool aiding memory, logic and problem solving has recently become well recognized. Virtual Cell will provide ...


Meta!Blast: A Serious Game To Explore The Complexities Of Structural And Metabolic Cell Biology, Eve S. Wurtele, Diane C. Bassham, Julie Dickerson, David J. Kabala, William Schneller, Mark Stenerson, Achyuthan Vasanth 2017 Iowa State University

Meta!Blast: A Serious Game To Explore The Complexities Of Structural And Metabolic Cell Biology, Eve S. Wurtele, Diane C. Bassham, Julie Dickerson, David J. Kabala, William Schneller, Mark Stenerson, Achyuthan Vasanth

Eve Wurtele

Knowledge of cellular structure and function has increased dramatically with the advent of modern molecular and computational technologies. Helping students to understand cellular dynamics is a major challenge to educators. To address this challenge, we have developed the Kabala Engine, an open source engine based on OpenSG (http://www.opensg.org) and VRJuggler (http://www.vrjuggler.org). This engine is designed to enable biologists, and indeed any domain expert — chemists, artists, psychologists — to create virtual interactive worlds for teaching or research. As a proof-of-concept, we have used this engine to create Meta!Blast, a virtual plant cell containing a prototype ...


Metnetge: Interactive Views Of Biological Networks And Ontologies, Jia Ming, Suh-Yeon Choi, Dirk Reiners, Eve S. Wurtele, Julie A. Dickerson 2017 Iowa State University

Metnetge: Interactive Views Of Biological Networks And Ontologies, Jia Ming, Suh-Yeon Choi, Dirk Reiners, Eve S. Wurtele, Julie A. Dickerson

Eve Wurtele

Background

Linking high-throughput experimental data with biological networks is a key step for understanding complex biological systems. Currently, visualization tools for large metabolic networks often result in a dense web of connections that is difficult to interpret biologically. The MetNetGE application organizes and visualizes biological networks in a meaningful way to improve performance and biological interpretability.

Results

MetNetGE is an interactive visualization tool based on the Google Earth platform. MetNetGE features novel visualization techniques for pathway and ontology information display. Instead of simply showing hundreds of pathways in a complex graph, MetNetGE gives an overview of the network using the ...


T1, T2, And Off-Resonance Mapping Using A Non-Linear Least-Squares Fit Of The Bssfp Signal, Meredith Taylor, Joseph Valentine, Steven Whitaker, Neal Bangerter 2017 Brigham Young University

T1, T2, And Off-Resonance Mapping Using A Non-Linear Least-Squares Fit Of The Bssfp Signal, Meredith Taylor, Joseph Valentine, Steven Whitaker, Neal Bangerter

Biomedical Engineering Western Regional Conference

The mapping of MR relaxation times has found a broad variety of applications in the study of disease. Unfortunately, the gold standards for acquiring T1 and T2 maps require long scan times, and are therefore more suited to 2D acquisitions with limited slices. For reasonable scan times, resolution is limited making these scans less useful for showing fine morphological detail. A rapid 3D sequence at higher resolutions that could be used to provide both morphological detail and relaxation time maps would be particularly useful. We propose a technique with potential to provide simultaneous band-free 3D datasets and estimates ...


Bssfp Elliptical Signal Model With Grappa Parallel Imaging, Grayson Tarbox, Joseph Valentine, Meredith Taylor, Neal Bangerter 2017 Brigham Young University

Bssfp Elliptical Signal Model With Grappa Parallel Imaging, Grayson Tarbox, Joseph Valentine, Meredith Taylor, Neal Bangerter

Biomedical Engineering Western Regional Conference

In magnetic resonance imaging, balanced steady-state free precession acquisition using the elliptical signal model geometrical solution can be combined with a GRAPPA parallel imaging reconstruction that preserves phase information to shorten scan times.


Water Fat Separation With Multiple-Acquisition Bssfp Mri, Michael A. Mendoza 8232743, Joseph Valentine, Neal Bangerter 2017 Brigham Young University

Water Fat Separation With Multiple-Acquisition Bssfp Mri, Michael A. Mendoza 8232743, Joseph Valentine, Neal Bangerter

Biomedical Engineering Western Regional Conference

We present a technique that combines the advantages of bSSFP MRI with Dixon reconstruction in order to produce robust water fat separation with high SNR in a short imaging time, while simultaneously reducing banding artifacts that traditionally degrade image quality.


3d Printed Microfluidics, Hua Gong, Clayton Ramstedt, Adam T. Woolley, Gregory P. Nordin 2017 Brigham Young University

3d Printed Microfluidics, Hua Gong, Clayton Ramstedt, Adam T. Woolley, Gregory P. Nordin

Biomedical Engineering Western Regional Conference

3D printing for microfluidic (lab-on-a-chip) devices


Toward Improving Electrocardiogram (Ecg) Biometric Verification Using Mobile Sensors: A Two-Stage Classifier Approach, Robin Tan, Marek Perkowski 2017 Portland State University

Toward Improving Electrocardiogram (Ecg) Biometric Verification Using Mobile Sensors: A Two-Stage Classifier Approach, Robin Tan, Marek Perkowski

Electrical and Computer Engineering Faculty Publications and Presentations

Electrocardiogram (ECG) signals sensed from mobile devices pertain the potential for biometric identity recognition applicable in remote access control systems where enhanced data security is demanding. In this study, we propose a new algorithm that consists of a two-stage classifier combining random forest and wavelet distance measure through a probabilistic threshold schema, to improve the effectiveness and robustness of a biometric recognition system using ECG data acquired from a biosensor integrated into mobile devices. The proposed algorithm is evaluated using a mixed dataset from 184 subjects under different health conditions. The proposed two-stage classifier achieves a total of 99.52 ...


Simulations Of A Variable Friction Device For Multihazard Mitigation, Liang Cao, Simon Laflamme, Douglas Taylor, James Ricles 2017 Iowa State University

Simulations Of A Variable Friction Device For Multihazard Mitigation, Liang Cao, Simon Laflamme, Douglas Taylor, James Ricles

Simon Laflamme

This paper investigates the performance of a novel semiactive damping device at mitigating nonsimultaneous multihazard loads. The device, termed modified friction device (MFD), has been previously proposed by the authors. It consists of a variable friction system based on automotive drum brake technology. The device has been demonstrated in a laboratory environment, and its dynamic behavior has been modeled. This model is used to conduct numerical simulations on two representative structures, one short building located in Japan and the other tall building located in Boston, MA. Simulated hazards include wind, blast, and seismic loads. Various control cases are considered, including ...


Reconstruction Of In-Plane Strain Maps Using Hybrid Dense Sensor Network Composed Of Sensing Skin, Austin R.J. Downey, Simon Laflamme, Filippo Ubertini 2017 Iowa State University

Reconstruction Of In-Plane Strain Maps Using Hybrid Dense Sensor Network Composed Of Sensing Skin, Austin R.J. Downey, Simon Laflamme, Filippo Ubertini

Simon Laflamme

The authors have recently developed a soft-elastomeric capacitive (SEC)-based thin film sensor for monitoring strain on mesosurfaces. Arranged in a network configuration, the sensing system is analogous to a biological skin, where local strain can be monitored over a global area. Under plane stress conditions, the sensor output contains the additive measurement of the two principal strain components over the monitored surface. In applications where the evaluation of strain maps is useful, in structural health monitoring for instance, such signal must be decomposed into linear strain components along orthogonal directions. Previous work has led to an algorithm that enabled ...


Design Of Radio-Frequency Arrays For Ultra-High Field Mri, Ian R O Connell 2017 The University of Western Ontario

Design Of Radio-Frequency Arrays For Ultra-High Field Mri, Ian R O Connell

Electronic Thesis and Dissertation Repository

Magnetic Resonance Imaging (MRI) is an indispensable, non-invasive diagnostic tool for the assessment of disease and function. As an investigational device, MRI has found routine use in both basic science research and medicine for both human and non-human subjects.

Due to the potential increase in spatial resolution, signal-to-noise ratio (SNR), and the ability to exploit novel tissue contrasts, the main magnetic field strength of human MRI scanners has steadily increased since inception. Beginning in the early 1980’s, 0.15 T human MRI scanners have steadily risen in main magnetic field strength with ultra-high field (UHF) 8 T MRI systems ...


A Wireless, Passive Sensor For Measuring Temperature At Orthopedic Implant Sites For Early Diagnosis Of Infections, Salil Sidharthan Karipott 2017 Michigan Technological University

A Wireless, Passive Sensor For Measuring Temperature At Orthopedic Implant Sites For Early Diagnosis Of Infections, Salil Sidharthan Karipott

Dissertations, Master's Theses and Master's Reports

Sensorized implants with embedded wireless, passive temperature sensors were developed for early detection of implant-associated infections. The operation principle of the sensor is based on the hypothesis that infections can lead to an increase in local temperature prior to the rise of body temperature. The sensor was an inductive capacitive (LC) circuit that has been used for monitoring of different parameters wirelessly, often in difficult to access environments. The sensor was fabricated on to an interference screw, which is used for tendon and ligament reconstruction surgeries. In this project, a sensorized interference screw was designed and fabricated by accommodating an ...


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