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Elucidating The Action Of A Regulatory Lipid Ligand Via Molecular Simulation: Cholesterol Swarms And The Inwardly Rectifying Potassium Channel, Belinda Akpa, Nicolas Barbera, Irena Levitan 2018 North Carolina State University

Elucidating The Action Of A Regulatory Lipid Ligand Via Molecular Simulation: Cholesterol Swarms And The Inwardly Rectifying Potassium Channel, Belinda Akpa, Nicolas Barbera, Irena Levitan

Biology and Medicine Through Mathematics Conference

No abstract provided.


Modeling Pharmaceutical Inhibition Of Glucose-Stimulated Renin-Angiotensin System In Kidneys, Ashlee N. Ford Versypt, Minu R. Pilvankar, Hui Ling Yong 2018 Oklahoma State University - Main Campus

Modeling Pharmaceutical Inhibition Of Glucose-Stimulated Renin-Angiotensin System In Kidneys, Ashlee N. Ford Versypt, Minu R. Pilvankar, Hui Ling Yong

Biology and Medicine Through Mathematics Conference

No abstract provided.


Learning In Bio-Molecular Computing Systems, Lauren Braun 2018 Portland State University

Learning In Bio-Molecular Computing Systems, Lauren Braun

Undergraduate Research & Mentoring Program

Many potential applications of biochemical computers involve the detection of highly adaptable and dynamic chemical systems, such as emerging pathogens. Current technology is expensive to develop and unique to each application, thus causing limitations in accessibility. In order to make this type of computing a realistic solution to problems in the medical field, a biochemical computer would need to be adaptable to work in a variety of applications. Banda et al. (2014) previously proposed a first dynamic biochemical system that was capable of autonomous learning. For this project we studied a framework similar to Banda’s but in two separate ...


Predicting The Dynamic Binding Capacities For Adsorbents Using Bsa As A Model Protein, Gaoshan Li 2018 Rose-Hulman Institute of Technology

Predicting The Dynamic Binding Capacities For Adsorbents Using Bsa As A Model Protein, Gaoshan Li

Rose-Hulman Undergraduate Research Publications

Membrane adsorbers are one alternative to traditional bead-based chromatography that receive attention in the bioseparation process because of their ability to process material with lower residence times. However some properties of membranes make membrane adsorbers unrealistic for some applications. For example, some membrane adsorbers exhibit lower binding capacities compared with the traditional bead-based chromatography counterparts. The dynamic binding capacity (DBC) in this study is defined as the amount of protein bound in the column when the outlet reaches a certain concentration, which is 10% [2], and the equilibrium binding capacity (EBC) is the binding capacity under the equilibrium conditions, when ...


Radical Social Ecology As Deep Pragmatism: A Call To The Abolition Of Systemic Dissonance And The Minimization Of Entropic Chaos, Arielle Brender 2018 Fordham University

Radical Social Ecology As Deep Pragmatism: A Call To The Abolition Of Systemic Dissonance And The Minimization Of Entropic Chaos, Arielle Brender

Student Theses 2015-Present

This paper aims to shed light on the dissonance caused by the superimposition of Dominant Human Systems on Natural Systems. I highlight the synthetic nature of Dominant Human Systems as egoic and linguistic phenomenon manufactured by a mere portion of the human population, which renders them inherently oppressive unto peoples and landscapes whose wisdom were barred from the design process. In pursuing a radical pragmatic approach to mending the simultaneous oppression and destruction of the human being and the earth, I highlight the necessity of minimizing entropic chaos caused by excess energy expenditure, an essential feature of systems that aim ...


Removal Of Carbamazepine From Drinking Water, Paola Marrero-Rivera, Adam Johnson, Jordan Alex Gadberry, Juan Rodriguez, Thomas Krumpolc, Zach Wiese 2018 University of Arkansas, Fayetteville

Removal Of Carbamazepine From Drinking Water, Paola Marrero-Rivera, Adam Johnson, Jordan Alex Gadberry, Juan Rodriguez, Thomas Krumpolc, Zach Wiese

Chemical Engineering Undergraduate Honors Theses

Due to the increasing prevalence of prescription medication over the past few decades, pharmaceuticals have accumulated in various water sources. This has become a public health concern because many pharmaceuticals have limited research on the effects of chronic low-level exposure.One pharmaceutical of interest that has been detected in water sources is carbamazepine. Carbamazepine (CBZ) is a common pharmaceutical prescribed for the treatment of seizure disorders, neuropathic pain, and various psychological disorders. It’s mechanism of action is “sodium channel blocking,” which is the impairment of conduction of sodium ions in sodium channels. This, in effect, reduces nervous-system conductivity in ...


Comparing Stenotic Blood Flow In Three- And Two-Dimensional Arterial Renderings Using Computational Fluid Dynamics And Multiphase Mean Age Theory., Jacob S. Garza 2018 University of Louisville

Comparing Stenotic Blood Flow In Three- And Two-Dimensional Arterial Renderings Using Computational Fluid Dynamics And Multiphase Mean Age Theory., Jacob S. Garza

Electronic Theses and Dissertations

Over one million invasive coronary angiography procedures are performed annually in patients who experience chest pain or are known to have coronary artery disease. The procedure is carried out to ascertain the degree of arterial blockage (stenosis) that hinders blood flow to the heart. A cardiologist performing the procedure determines the physiological degree of a stenosis by either visual estimation, which is routine practice, or by invasively measuring fractional flow reserve (FFR), which is the current gold standard that has been demonstrated to improve patient outcomes and temper the cost of healthcare. Nevertheless, FFR is performed in only 10–20 ...


Biobutanol Production From Cellulosic And Sugar-Based Feedstock From The Corn Plant, Reyna Gomez-Flores 2018 The University of Western Ontario

Biobutanol Production From Cellulosic And Sugar-Based Feedstock From The Corn Plant, Reyna Gomez-Flores

Electronic Thesis and Dissertation Repository

In this thesis, biobutanol production by biological fermentation was investigated from the corn plant, integrating two approaches. The first one was to utilize corn cobs, a cellulosic-based material. The second, using a new sugar-based material, sugarcorn juice. Utilizing suitable Clostridia strains for each substrate, these approaches converged into a biorefinery concept to produce renewable biofuels in Ontario, Canada. The corn cob pretreatment was carried out by a dilute acid method resulting in temperature as the variable with most significant effect towards glucose liberation. The enzymatic hydrolysis was performed utilizing a very low concentration of an enzymatic stock solution with approximately ...


Oxy Fuel For Clean Energy Generation, Patrick J. Hally, Najib M. Muqeem, Colin B. Richter, Timothy R. Schanstra 2018 University of Pennsylvania

Oxy Fuel For Clean Energy Generation, Patrick J. Hally, Najib M. Muqeem, Colin B. Richter, Timothy R. Schanstra

Senior Design Reports (CBE)

This process explores several concentrations of oxygen-enriched air streams (oxy fuel) in combination with natural gas to generate steam for a steam turbine power plant with 30 MW capacity. The proposed location for this plant is the gulf coast of the United States. The oxy fuel concentrations tested were 36 mol. %, 53 mol. %, and 95 mol. %. Nitrogen removed from air would be sold as well as the 30 MW of electricity. The three oxygen purities were not profitable for the most realistic prices of electricity, nitrogen, and natural gas. However, the scenarios were all profitable with prices of nitrogen above ...


Bio-Dodecanedioic Acid (Ddda) Production, Brandon M. Mills, Meghavi M. Talati, Gregory A. Winter 2018 University of Pennsylvania

Bio-Dodecanedioic Acid (Ddda) Production, Brandon M. Mills, Meghavi M. Talati, Gregory A. Winter

Senior Design Reports (CBE)

The demand for dodecanedioic acid (DDDA) is steadily increasing each year with demand expected to exceed 90.4 kilotons per month in 2023.1.1 DDDA is an intermediate chemical used in a variety of end products. Thus, the increase in DDDA demand can largely be attributed to increasing demand for manufacturing nylon, paints, adhesives, and powder coatings. Regionally, Asia Pacific has been observing the fastest growth of all regions at over 6% CAGR.1.2 The robust manufacturing base for nylon, along with a growing automotive industry in India and China, will propel DDDA growth into the next decade ...


Sodium And Specialty Cyanides Production Facility, Nicholas A. Baylis, Parth N. Desai, Kyle J. Kuhns 2018 University of Pennsylvania

Sodium And Specialty Cyanides Production Facility, Nicholas A. Baylis, Parth N. Desai, Kyle J. Kuhns

Senior Design Reports (CBE)

Sodium cyanide and specialty cyanide production are essential operations for various industrial processes, with primary applications in mining and mineral processing. Sodium cyanide, despite the high toxicity inherent in the material and its production process, is expected to grow 5% annually, with a projected global demand of 1.1 million tonnes in 2018. This report details a process design for producing sodium cyanide through the use of two intermediate reactions and successive downstream separations. The first major step is the production of hydrogen cyanide gas from ammonia and methane derived from natural gas, via the industry standard Andrussow reaction over ...


Design Of A Flexible, High-Volume Direct Flue Gas-To-Algae Conversion Process For Value-Added Bioproducts, Casey M. Barkan, Kyle A. DeLuca, Mikaela R. Preston 2018 University of Pennsylvania

Design Of A Flexible, High-Volume Direct Flue Gas-To-Algae Conversion Process For Value-Added Bioproducts, Casey M. Barkan, Kyle A. Deluca, Mikaela R. Preston

Senior Design Reports (CBE)

Carbon conversion processes (where carbon dioxide is not only captured and stored, but converted to commercially-valuable products) have high barriers to sustained and large-scale commercial viability. Mass algae production as a means to carbon emissions reductions is considered to have great commercial potential, but the viability of deployment is going to rely on technological leaps supported by strong public and private investment. Presented in this Design Report is a novel pilot-scale microalgae cultivation system that successfully converts over 50% of the carbon dioxide (CO2) present in a stream of flue gas from a coal-red power plant flue gas into ...


Chemical Recycling Of Polystyrene Using Pyrolysis, Jade H. Bassil, Gabrielle Dreux, Gwendolyn A. Eastaugh 2018 University of Pennsylvania

Chemical Recycling Of Polystyrene Using Pyrolysis, Jade H. Bassil, Gabrielle Dreux, Gwendolyn A. Eastaugh

Senior Design Reports (CBE)

There are significant economic and environmental benefits to the recycling of waste plastics, especially that of polystyrene. Currently, much of polystyrene waste is sent to landfills due to the difficulty in separation and cleaning processes, where it accumulates indefinitely. It contributes to plastic pollution and adversely affects wildlife, oceans and humans. Pyrolysis of waste polystyrene is explored in this paper as a chemical recycling method. This reaction yields useful liquid fuel products such as styrene, ethylbenzene, toluene, and methylstyrene, which can be sold to provide project revenues. Beginning with a polystyrene feed of 100 tons per day, the suggested design ...


Monoclonal Antibody Production And Purification, Hope E. McMahon, Jessica W. Schwartz, Shritama Ray 2018 University of Pennsylvania

Monoclonal Antibody Production And Purification, Hope E. Mcmahon, Jessica W. Schwartz, Shritama Ray

Senior Design Reports (CBE)

Monoclonal antibody (mAb) therapy is a form of immunotherapy that uses mAbs to bind mono-specifically to certain cells or proteins. This may then stimulate the patient's immune system to attack those cells. MAbs are currently used to treat medical conditions such as cancer, diabetes, arthritis, psoriasis, and Crohn’s Disease, but have the potential to treat countless diseases and disorders. In 2015, the mAb market was valued at $85.4 billion, and is expected to reach $138.6 billion by 2024.1 In manufacturing, mAbs are typically produced in suspension in a series of fed-batch bioreactors using genetically engineered ...


Production Of Universal Red Blood Cells Via Enzymatic Conversion, Carly M. Catella, Rachel A. Coler, Brandon H. Hayes 2018 University of Pennsylvania

Production Of Universal Red Blood Cells Via Enzymatic Conversion, Carly M. Catella, Rachel A. Coler, Brandon H. Hayes

Senior Design Reports (CBE)

Red blood cell (RBC) transfusion units are considered one of the most essential healthcare components in the world. In the United States alone, approximately 21 million transfusion units are required every year. Despite this high demand, RBC units are becoming increasingly scarce since only a fraction of eligible donors provide RBCs to for medical use. Additionally, RBC transfusions are limited to immune compatibility in patients, making it difficult to serve all patients with such a limited supply. This proposed design provides a method in which RBCs of any blood group can be converted into the universal blood type, O, to ...


Process For Sustainably Sourced P-Xylene, Grace Memmo, John C. Newlon, Xiaoxin Tang 2018 University of Pennsylvania

Process For Sustainably Sourced P-Xylene, Grace Memmo, John C. Newlon, Xiaoxin Tang

Senior Design Reports (CBE)

Demand for para-xylene, a feedstock used to produce polyethylene terephthalate (PET) plastics like those found in water bottles or textile fibers, has risen steadily.14 In the PET market, there is a new sustainable focus, pushing producers to use environmentally-friendly processes to create plastic consumer products.3 The current process to create para-xylene relies on fossil fuel cracking and reforming - a decidedly non-green process. This project follows a patent by GEVO, titled Integrated Process to Selectively Convert Renewable Isobutanol to p-Xylene, that explores a green process to convert isobutanol, created from biomass, to para-xylene.20 The raw material for this ...


Production Of Malonic Acid Through The Fermentation Of Glucose, Emily P. Peters, Gabrielle J. Schlakman, Elise N. Yang 2018 University of Pennsylvania

Production Of Malonic Acid Through The Fermentation Of Glucose, Emily P. Peters, Gabrielle J. Schlakman, Elise N. Yang

Senior Design Reports (CBE)

The overall process to produce malonic acid has not drastically changed in the past 50 years. The current process is damaging to the environment and costly, requiring high market prices. Lygos, Inc., a lab in Berkeley, California, has published a patent describing a way to produce malonic acid through the biological fermentation of genetically modified yeast cells. This proposed technology is appealing as it is both better for the environment and economically friendly.

For the process discussed in this report, genetically modified Pichia Kudriavzevii yeast cells will be purchased from the Lygos lab along with the negotiation of exclusive licensing ...


Alternative Technology For Sour Water Stripping, Andrew E. Frederick, Connor T. Leach, Christelle U. Nayandi 2018 University of Pennsylvania

Alternative Technology For Sour Water Stripping, Andrew E. Frederick, Connor T. Leach, Christelle U. Nayandi

Senior Design Reports (CBE)

No abstract provided.


Hydrothermal Liquefaction Of Microalgae For The Production Of Bio-Crude Oil, Yulin Hu 2018 The University of Western Ontario

Hydrothermal Liquefaction Of Microalgae For The Production Of Bio-Crude Oil, Yulin Hu

Electronic Thesis and Dissertation Repository

Due to the depletion of fossil fuels and climate change, extensive research has performed towards renewable energy production from microalgal biomass. Microalgae have several inherent benefits, such as high photosynthetic efficiencies, fast growth rates, and high lipid contents. In addition, microalgae can be cultivated in the non-arable lands (e.g., saline and waste water), thereby no competition with food crops production.

Transesterification is the one of commonly used technologies for converting microalgae into liquid bio-fuels (i.e., biodiesel). Normally, an energy-intensive drying step is required in the transesterification treatment, which accounts for nearly half of the energy input. Hence, if ...


Engineering Of E. Coli Inherent Fatty Acid Biosynthesis Capacity To Increase Octanoic Acid Production, Zaigao Tan, Jong Moon Yoon, Anupam Chowdhury, Kaitlin Burdick, Laura R. Jarboe, Costas D. Maranas, Jacqueline V. Shanks 2018 Iowa State University

Engineering Of E. Coli Inherent Fatty Acid Biosynthesis Capacity To Increase Octanoic Acid Production, Zaigao Tan, Jong Moon Yoon, Anupam Chowdhury, Kaitlin Burdick, Laura R. Jarboe, Costas D. Maranas, Jacqueline V. Shanks

Chemical and Biological Engineering Publications

Background

As a versatile platform chemical, construction of microbial catalysts for free octanoic acid production from biorenewable feedstocks is a promising alternative to existing petroleum-based methods. However, the bio-production strategy has been restricted by the low capacity of E. coli inherent fatty acid biosynthesis. In this study, a combination of integrated computational and experimental approach was performed to manipulate the E. coli existing metabolic network, with the objective of improving bio-octanoic acid production.

Results

First, a customized OptForce methodology was run to predict a set of four genetic interventions required for production of octanoic acid at 90% of the theoretical ...


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