Evaluation Of Upper Motor Neuron Pathology In Amyotrophic Lateral Sclerosis By Mri;Towards Identifying Noninvasive Biomarkers Of The Disease, Venkateswaran Rajagopalan
Amyotrophic lateral sclerosis (ALS) is the commonest adult motor neuron disease (MND) which causes progressive muscle paralysis and death usually within 5 years of symptom onset. As a result, only ╠â30,000 individuals in the United States are afflicted at any one time even though 5,000 or more individuals are diagnosed yearly. The diagnosis of ALS requires evidence of degeneration in upper motor neurons (UMNs) in the brain and in lower motor neurons (LMNs) that exit the brainstem and spinal cord to innervate skeletal muscles. Diagnosis can be incorrect or delayed when disease is early or atypical because non-invasive ...
Finite Element Modeling Of Stress Urinary Incontinence Mechanics, 2010 Cleveland State University
Finite Element Modeling Of Stress Urinary Incontinence Mechanics, Thomas A. Spirka
Stress urinary incontinence is characterized by the involuntary transurethral loss of urine caused by an increase in abdominal pressure in the absence of a bladder contraction that raises the vesical pressure to a level that exceeds urethral pressure. Adult women are most commonly affected by SUI which is believed to be caused in part by injuries to the pelvic floor sustained during childbirth. In spite of the large number of women affected by SUI, little is known about the mechanics associated with the maintenance of continence in women. In theory the mechanics underlying the mechanics of female continence can be ...
Cell-Taught Gene Therapy For The Preservation And Regeneration Of Cardiac Tissue Following Chronic Heart Failure, 2010 Cleveland State University
Cell-Taught Gene Therapy For The Preservation And Regeneration Of Cardiac Tissue Following Chronic Heart Failure, Srividya Sundararaman
Heart failure is the primary cause of mortality and morbidity in the Western world. Although cell therapy has demonstrated improvement in cardiac function, these benefits are being attributed to the activation of paracrine factors, rather than the differentiation and integration of the transplanted cells into the host tissue. Based on this knowledge the focus of this thesis work was to deliver paracrine factors, and evaluate its effect on cardiac function. Gene therapy has evolved as a promising option to deliver pro-angiogenic proteins to infarct zones, thus providing cardiac benefit. This study has identified a gene design without the use of ...
Design, Development And Biomechanical Analysis Of Scaffolds For Augmentation Of Rotator Cuff Repairs, 2010 Cleveland State University
Design, Development And Biomechanical Analysis Of Scaffolds For Augmentation Of Rotator Cuff Repairs, Amit Aurora
Rotator cuff tears are a source of debilitating pain that commonly affects more than 40 of our aging population. Despite advances in surgical treatment, the failure rate of rotator cuff repairs is as high as 20-90 . Extracellular matrix (ECM) derived scaffolds have recently been investigated as augmentation devices for rotator cuff repairs, but none has yet demonstrated both the appropriate biological and mechanical properties for mitigating re-tears and enhancing healing. This dissertation proposes to engineer the mechanical properties of allograft fascia lata in a manner that will allow its use as an augmentation device for rotator cuff repairs. This dissertation ...
The Thermodynamics Of Fluid-Phase Benzene Via Molecular Simulation, 2010 Cleveland State University
The Thermodynamics Of Fluid-Phase Benzene Via Molecular Simulation, John L. Tatarko
Accurate values for thermodynamic properties throughout the fluid phase are a requirement for the design of separation processes. To date, very few pure substances have been completely characterized because of time and monetary constraints. Low cost computing power now permits complete determination of the thermodynamic properties of pure substances via molecular simulation. Molecular simulation is computational statistical mechanics. Benzene is an important industrial chemical and pharmaceutical precursor. It is the prototypical, symmetric, hexagonal molecule and is an ideal candidate for molecular simulation. The molecular models of three researchers in the field are submitted for Monte Carlo simulation in the virtual ...
Directional Solidification Of Al - 7 Wt Si Alloy, 2010 Cleveland State University
Directional Solidification Of Al - 7 Wt Si Alloy, Ravi Shanker Rajamure
Al - 7 wt Si alloy has been directionally solidified from an aluminum single crystal seed with its  orientation parallel to the growth direction with a positive thermal gradient of 40 K/cm and over the range of growth speeds. Growth speed dependence of primary Dendrite Spacing and Primary Dendrite trunk Diameter has been analyzed during the step increase and step decrease in the growth speeds. Frequency distribution of Nearest Neighbor dendrites obtained from the statistical analysis shows the hexagonal distribution of dendrites. The interdendritic convection was present in the form of transverse macrosegregation and non uniform distribution of dendrites ...
Merlin.Net Automation Of External Reports Verification Process, 2010 California Polytechnic State University, San Luis Obispo
Merlin.Net Automation Of External Reports Verification Process, Gabriel John Wettlaufer
Master's Theses and Project Reports
Merlin.net Patient Care Network is a St. Jude Medical product that is used for remote patient management. The basic concept of Merlin.net is to allow the physician to view patient device follow-up information as well as general patient and device information on a web application. The Merlin.net system also interfaces with the patient and will send them notification if they miss a follow-up. All device information will be collected automatically while the patient is sleeping. This information is sent through a telephone line to a Merlin.net server to process a report package and display the collected ...
Quantification Of Vascular Parametric Indices Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging, 2010 Wayne State University
Quantification Of Vascular Parametric Indices Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging, Areen Khaled Al.Bashir
Wayne State University Dissertations
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is a non-invasive method used to evaluate the biological activity in early clinical trials of novel drugs targeting the tumor vasculature using gadolinium-DTPA (Gd) as a contrast agent. However, it has some limitations, such as reproducibility, data acquisition times, the presence of noise, extracting contrast concentration, estimating T1 relaxation and estimating pharmacokinetic parameters.
In this work, a new approach to used fixed T1(0) which provides more reproducible DCE results has been introduced. Using this new algorithm to quantify the vascular changes in DCE-MRI, a pre-clinical renal cell carcinoma (RCC) tumor model was used ...
Imaging The Vasculature With Susceptibility Weighted Imaging: Applications And Analysis, 2010 Wayne State University
Imaging The Vasculature With Susceptibility Weighted Imaging: Applications And Analysis, Samuel Barnes
Wayne State University Dissertations
Modern magnetic resonance imaging sequences allow detailed non-invasive imaging of both the arteries and veins. This work is divided into four sections that examine different applications and analysis of these sequences.
Susceptibility weighted imaging (SWI) typically generates excellent negative venous contrast. Techniques to generate positive arterial contrast in SWI images without degrading the venous contrast with a single echo are examined. By using high isotropic resolution and high readout bandwidth flow losses can be minimized (generating good arterial contrast) even at the long echo times required for good venous contrast. A downsampling filter is then used to restore lost venous ...
Influence Of Traumatic Impaction And Pathological Loading On Knee Menisci, 2010 Michigan Technological University
Influence Of Traumatic Impaction And Pathological Loading On Knee Menisci, Megan Leigh Killian
Dissertations, Master's Theses and Master's Reports - Open
Nearly half of the US population faces the risk of developing knee osteoarthritis (OA). Both in vitro and in vivo studies can aid in a better understanding of the etiology, progression, and advancement of this debilitating disorder. The knee menisci are fibrocartilagenous structures that aid in the distribution of load, attenuation of shock, alignment and lubrication of the knee. Little is known about the biochemical and morphological changes associated with knee menisci following altered loading and traumatic impaction, and investigations are needed to further elucidate how degradation of this soft tissue advances over time. The biochemical response of porcine meniscal ...
Anterior-Posterior Impedance Cardiography: A New Approach To Accurate, Non-Invasive Monitoring Of Cardiac Function, Charles F. Babbs
Weldon School of Biomedical Engineering Faculty Publications
The conventional impedance cardiogram is a record of pulsatile changes in the electrical impedance of the chest with each heartbeat. The signal seems intuitively related to cardiac stroke volume. However doubts persist about the validity of stroke volume measurements based on electrical impedance. This paper presents a new electrical axis for impedance cardiography that is perpendicular to the conventional head-to-foot axis in an anterior-posterior direction. Dual chest and back electrodes are concentric, permitting tetrapolar technique. A relatively simple analytical model is developed, and this model is validated in a three-dimensional finite element model of current flow through the human chest ...
Optimization And Economic Evaluation Of Industrial Gas Production, 2009 University of Nebraska Lincoln
Optimization And Economic Evaluation Of Industrial Gas Production, Yasar Demirel, A. Kumar, D.D. Jones, M.A. Hanna
Thermochemical gasification is one of the most promising technologies for converting biomass into power, fuels and chemicals. The objectives of this study were to maximize the net energy efficiency for biomass gasification, and to estimate the cost of producing industrial gas and combined heat and power (CHP) at a feedrate of 2000 kg/h. Aspen Plus-based model for gasification was combined with a CHP generation model, and optimized using corn stover and dried distillers grains with solubles (DDGS) as the biomass feedstocks. The cold gas efficiencies for gas production were 57% and 52%, respectively, for corn stover and DDGS. The ...
A Review Of Autoimmune Diseases Associated With Cancer, 2009 University of Saskatchewan
A Review Of Autoimmune Diseases Associated With Cancer, Patricia Tai, Edward Yu, Kurian Joseph, Thomas Miale
The focus of this review is on the relationships between autoimmune diseases and cancer from two closely related perspectives: 1.Those autoimmune diseases which are often associated with malignancies. 2.Those prevalent cancers which may increase the risks of developing autoimmune disorders. The review concludes with a brief discussion of some selected innovative approaches to cancer immunotherapy.
Viscoelastic Properties Of Macaque Neural Tissue At Low Strain Rates, 2009 Ohio State University