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Assessing The Therapeutic Effect Of 630 Nm Light-Emitting Diodes Irradiation On The Recovery Of Exercise-Induced Hand Muscle Fatigue With Surface Electromyogram, Dandan Yang, Xiaoying Wu, Wensheng Hou, Xiaolin Zheng, Jun Zheng, Yingtao Jiang 2012 Chongqing University

Assessing The Therapeutic Effect Of 630 Nm Light-Emitting Diodes Irradiation On The Recovery Of Exercise-Induced Hand Muscle Fatigue With Surface Electromyogram, Dandan Yang, Xiaoying Wu, Wensheng Hou, Xiaolin Zheng, Jun Zheng, Yingtao Jiang

Electrical and Computer Engineering Faculty Publications

This paper aims to investigate the effect of light emitting diode therapy (LEDT) on exercise-induced hand muscle fatigue by measuring the surface electromyography (sEMG) of flexor digitorum superficialis. Ten healthy volunteers were randomly placed in the equal sized LEDT group and control group. All subjects performed a sustained fatiguing isometric contraction with the combination of four fingertips except thumb at 30% of maximal voluntary contraction (MVC) until exhaustion. The active LEDT or an identical passive rest therapy was then applied to flexor digitorum superficialis. Each subject was required to perform a re-fatigue task immediately after therapy which was the same ...


Effect Of Size Reduction Parameters In Pharmaceutical Manufacturing Process, Brian Breneman 2011 California Polytechnic State University - San Luis Obispo

Effect Of Size Reduction Parameters In Pharmaceutical Manufacturing Process, Brian Breneman

Biomedical Eng/General Eng.

Within pharmaceutical manufacturing, size reduction is one of the most extensively used and vital unit operations. Size reduction in tablet production is achieved primarily through milling procedures, which allows for attaining product uniformity, optimizing product solubility, and improving bioavailability. Additionally, powders with a narrow range of size distribution can obviate problems in downstream processing as pertains to blending, compression, and coating as well as improve drug performance1. The purpose this study was to characterize the effect of various size reduction parameters as a result of the pharmaceutical milling process on a lactose wet granulation formulation and chemically active extruded ...


Impact Of Collateral Enlargement On Smooth Muscle Phenotype, Alexander Jerome Bynum 2011 California Polytechnic State University - San Luis Obispo

Impact Of Collateral Enlargement On Smooth Muscle Phenotype, Alexander Jerome Bynum

Master's Theses and Project Reports

Peripheral Artery Disease is a very serious disease characterized by an arterial occlusion due to atherosclerotic plaques. In response to an arterial occlusion, arteriogenesis occurs, causing smooth muscle cells to transition from a contractile to synthetic state. Also following an arterial occlusion, functional impairment was seen in the collateral circuit. An immunofluorescence protocol was developed in order to assess the impact of collateral enlargement (arteriogenesis) on smooth muscle phenotype at various time points. Smooth muscle α-actin was used to mark all smooth muscle cells, Ki-67 was used to label proliferating smooth muscle cells, and a fluorescent nuclear stain was used ...


A Novel Free Form Femoral Cutting Guide, Wesley Andrew Underwood 2011 University of Tennessee, Knoxville

A Novel Free Form Femoral Cutting Guide, Wesley Andrew Underwood

Masters Theses

Knee arthoplasty is a common procedure that requires the removal of damaged bone and cartilage from the distal femur so that a reconstructive implant may be installed. Traditionally, a five planar resection has been accomplished with a universal cutting box and navigated with either metal jigs or optically tracked computer navigation systems. Free form, or curved, resections have been made possible with surgical robots which control the resection pathway and serve as the navigation system. The free form femoral cutting guide serves as a non powered framework to guide a standard surgical drill along an anatomically defined pathway, resulting in ...


Course Of Illness And The Development Of Vascular Disease In Individuals With Bipolar Disorder, Jess G. Fiedorowicz 2011 University of Iowa

Course Of Illness And The Development Of Vascular Disease In Individuals With Bipolar Disorder, Jess G. Fiedorowicz

Theses and Dissertations

For over a century, there have been suggestions of a link between what is currently called bipolar disorder and cardiovascular mortality. In the contemporary epidemiological literature, this risk has been confirmed and approximates twice that expected based on age and gender. To date, however, this information has come primarily from clinical samples, which carry considerable risk of selection bias. The studies contained in this dissertation sought to assess this relationship using methods less vulnerable to selection bias and to determine the role that course of illness and treatments for illness may play in the development of vascular disease. In a ...


Glucose Biosensor Using Electrospun Mn2o3-Ag Nanofibers, Shan Huang 2011 University of Connecticut

Glucose Biosensor Using Electrospun Mn2o3-Ag Nanofibers, Shan Huang

Master's Theses

The highly porous Mn2O3-Ag nanofibers were fabricated by a facile two-step procedure (electrospinning and calcination) and then employed as the immobilization matrix for glucose oxidase (GOD) to construct an amperometric glucose biosensor. A notable enhancement of direct electron transfer between GOD and the electrode is observed at the Mn2O3-Ag-GOD modified electrode with a fast electron transfer rate constant. The biosensor also shows fast response to glucose, high sensitivity (40.60 μA×mM-1×cm-2), low detection limit (1.73 µM at S/N=3), low Km,app value and excellent ...


In-Vivo Ct Dosimetry During Virtual Colonoscopy, Jonathon W. Mueller 2011 The University of Texas Graduate School of Biomedical Sciences at Houston

In-Vivo Ct Dosimetry During Virtual Colonoscopy, Jonathon W. Mueller

UT GSBS Dissertations and Theses (Open Access)

Virtual colonoscopy (VC) is a minimally invasive means for identifying colorectal polyps and colorectal lesions by insufflating a patient’s bowel, applying contrast agent via rectal catheter, and performing multi-detector computed tomography (MDCT) scans. The technique is recommended for colonic health screening by the American Cancer Society but not funded by the Centers for Medicare and Medicaid Services (CMS) partially because of potential risks from radiation exposure. To date, no in‐vivo organ dose measurements have been performed for MDCT scans; thus, the accuracy of any current dose estimates is currently unknown.

In this study, two TLDs were affixed to ...


Applications Of Nanoparticle Image Velocimetry In Nanofluids, Sara Salim Haque 2011 University of Tennessee, Knoxville

Applications Of Nanoparticle Image Velocimetry In Nanofluids, Sara Salim Haque

Masters Theses

Particle Image Velocimetry (PIV) is an optical technique used for the visualization of fluid flow. PIV can be combined with other techniques to enhance the analysis of fluid flow. A novel far-field plasmonic resonance enhanced nanoparticle-seeded Particle Image Velocimetry (nPIV) has been demonstrated to measure the velocity in a micro channel. Chemically synthesized silver nanoparticles have been used to seed the flow. By using Discrete Dipole Approximation (DDA), plasmonic resonance enhanced light scattering has been calculated for spherical silver nanoparticles with diameters ranging from 15 nm to 200 nm in two media: water and air. The diffraction-limited plasmonic resonance enhanced ...


Seasonal Initial Concentrations And In-Field Decay Rates Of Escherichia Coli And Bovine Bacteroidetes In Beef Cattle Manure, Jiangwei Liu 2011 University of Tennessee, Knoxville

Seasonal Initial Concentrations And In-Field Decay Rates Of Escherichia Coli And Bovine Bacteroidetes In Beef Cattle Manure, Jiangwei Liu

Masters Theses

Eight naturally deposited beef cow manure patties were sampled during summer (July 19 to August 9, 2010), fall (October 26 to November 19, 2010), winter (January 14 to February 18, 2011), and spring (May 5-27, 2011) to determine whether hypothesized seasonal differences existed in the initial concentrations and decay rates of Escherichia coli (E. coli) and bovine Bacteroidetes (BoBac). E. coli concentrations were estimated as culturable colony forming units (CFU) and with a quantitative polymerase chain reaction (qPCR) assay targeting the 23S ribosomal gene. BoBac was quantified with a qPCR assay targeting a 16S ribosomal gene sequence associated with cattle ...


Zein Nanospheres For Gene Delivery, Mary C. Regier 2011 University of Nebraska-Lincoln

Zein Nanospheres For Gene Delivery, Mary C. Regier

Biological Systems Engineering--Dissertations, Theses, and Student Research

Particulates incorporating DNA provide for protection and sustained release of DNA, and thus are promising candidates for DNA delivery systems. Among the routes of administration for gene delivery, the oral route is perhaps the most appealing as it is associated with patient comfort and compliance and allows for targeting to intestinal targets for therapeutic and vaccination applications. With the goal of realizing the potential of an oral DNA delivery system, zein, a hydrophobic protein from corn that is biocompatible and degraded enzymatically, was investigated. This thesis describes the formulation of zein nanospheres encapsulating DNA by a coacervation technique and their ...


An Inexpensive Method For Creating Paste To Be Used In Paper-Based Microfluidic Devices, Kirra Marie Sankey 2011 California Polytechnic State University - San Luis Obispo

An Inexpensive Method For Creating Paste To Be Used In Paper-Based Microfluidic Devices, Kirra Marie Sankey

Biomedical Eng/General Eng.

Microfluidic devices are diagnostic tools that are small, portable, and inexpensive. This makes them ideally suited for resource-limited settings. To construct a 3D device, each layer of patterned paper is stacked using double-sided tape with holes corresponding to the pattern. It is necessary to have a paste to fill the holes in the tape and provide a medium for the fluid to wick through. The powder used to make the paste is very expensive and must be bought in bulk (an estimated $1121 - $1231), so it is not convenient for the Biomedical (BMED) department to use. This project was ...


Ischemia Impairs Vasodilation In Skeletal Muscle Resistance Artery, Kyle Remington Struthers 2011 California Polytechnic State University - San Luis Obispo

Ischemia Impairs Vasodilation In Skeletal Muscle Resistance Artery, Kyle Remington Struthers

Master's Theses and Project Reports

Functional vasodilation in arterioles is impaired with chronic ischemia. We sought to examine the impact of chronic ischemia and age on skeletal muscle resistance artery function. To examine the impact of chronic ischemia, the femoral artery was resected from young (2-3mo) and adult (6-7mo) mice and the profunda femoris artery diameter was measured at rest and following gracilis muscle contraction 14 days later using intravital microscopy. Functional vasodilation was significantly impaired in ischemic mice (14.4±4.6% vs. 137.8±14.3%, p<0.0001 n=8) and non-ischemic adult mice (103.0±9.4% vs. 137.8±14.3%, p=0.05 n=10). In order to analyze the cellular mechanisms of the impairment, a protocol was developed to apply pharmacological agents to the experimental preparation while maintaining tissue homeostasis. Endothelial and smooth muscle dependent vasodilation were impaired with ischemia, 39.6 ± 13.6% vs. 80.5 ± 11.4% and 43.0 ± 11.7% vs. 85.1 ± 10.5%, respectively. From this data, it can be supported that smooth muscle dysfunction is the reason for the observed impairment in arterial vasodilation.


Unveiling The Molecular Mechanisms Regulating The Activation Of The Erbb Family Receptors At Atomic Resolution Through Molecular Modeling And Simulations, Andrew Shih 2011 University of Pennsylvania

Unveiling The Molecular Mechanisms Regulating The Activation Of The Erbb Family Receptors At Atomic Resolution Through Molecular Modeling And Simulations, Andrew Shih

Publicly Accessible Penn Dissertations

The EGFR/ErbB/HER family of kinases contains four homologous receptor tyrosine kinases that are important regulatory elements in key signaling pathways. To elucidate the atomistic mechanisms of dimerization-dependent activation in the ErbB family, we have performed molecular dynamics simulations of the intracellular kinase domains of the four members of the ErbB family (those with known kinase activity), namely EGFR, ErbB2 (HER2) and ErbB4 (HER4) as well as ErbB3 (HER3), an assumed pseudokinase, in different molecular contexts: monomer vs. dimer, wildtype vs. mutant. Using bioinformatics and fluctuation analyses of the molecular dynamics trajectories, we relate sequence similarities to correspondence of ...


A Comparative Study Of Total Hemoglobin Measurement Technology: Noninvasive Pulse Co-Oximetry And Conventional Methods, Jared S. Ruckman 2011 University of Connecticut

A Comparative Study Of Total Hemoglobin Measurement Technology: Noninvasive Pulse Co-Oximetry And Conventional Methods, Jared S. Ruckman

Master's Theses

Hemoglobin can be measured on a variety of devices using different principles of operation. Noninvasive pulse CO-oximetry represents the latest development in hemoglobin measuring technology. The technology uses principles similar to pulse oximetry to measure total hemoglobin, oxyhemoglobin, reduced oxyhemoglobin, carboxyhemoglobin and methemoglobin. Similar to the introduction of pulse oximetry to the medical field, pulse CO-oximetry has been met with skepticism. Since the technology is noninvasive and provides continuous monitoring in comparison to invasive and discrete techniques used in other methods, CO-oximetry purportedly provides an advantage in patient care. The purpose of this research is threefold: (a) to review the ...


Modeling Of Human Hand Motion In A Maya Environment, Andrew M. Quinn, Aeshan Ali, Tessa Taylor, Quincy Beasley 2011 University of Tennessee, Knoxville

Modeling Of Human Hand Motion In A Maya Environment, Andrew M. Quinn, Aeshan Ali, Tessa Taylor, Quincy Beasley

University of Tennessee Honors Thesis Projects

No abstract provided.


Mammary Epithelial Cell Growth On A Three-Dimensional Scaffold In An Operating Bioreactor, Melissa Marie DaValle 2011 California Polytechnic State University - San Luis Obispo

Mammary Epithelial Cell Growth On A Three-Dimensional Scaffold In An Operating Bioreactor, Melissa Marie Davalle

Master's Theses and Project Reports

Mammary epithelial cells are highly efficient secreting cells. With genetic engineering, the uses of these cells could be endless. Research is being conducted on these cells to determine their full potential to the biotech industry.

This paper investigates whether bovine epithelial mammary cells can survive in glutaraldehyde-treated gelatin tubes in an operating bioreactor. Many bioreactors were developed and tested to suit the needs of the cells. Procedures were created and carried out to ensure sterility of the bioreactors. Bovine mammary epithelial cells were implanted in the bioreactors and samples of their growth were taken over time.


The Effect Of Maternal Diet On Fetal Development, Catherine Wilcox 2011 Syracuse University

The Effect Of Maternal Diet On Fetal Development, Catherine Wilcox

Syracuse University Honors Program Capstone Projects

Using mice as a model system, this study aimed to compare the effect of a high fat diet (HFD), high sugar diet (HSD) and a control diet (CD) on fetal growth and development at the time of birth (post-natal day 0 or PND 0), post-natal day 7 (PND 7) and post-natal day 14 (PND 14). Published literature has documented the effects of a negative in-utero environment on fetal development, but currently there is limited research regarding the continued effects on development after birth. Mouse pups were harvested and then imaged in 3-D using a high-resolution micro-computed tomography (micro-CT) system. Total ...


A Study Of Osteocyte Apoptosis By Region And Quadrant In Murine Cortical Bone, Jessica Kristen Chan 2011 California Polytechnic State University - San Luis Obispo

A Study Of Osteocyte Apoptosis By Region And Quadrant In Murine Cortical Bone, Jessica Kristen Chan

Master's Theses and Project Reports

ABSTRACT

A Study of Osteocyte Apoptosis by Region and Quadrant in Murine Cortical Bone

Jessica Kristen Chan

Osteocytes undergo apoptosis to spatially and temporally initiate bone remodeling. This study investigates the distribution of apoptotic osteocytes within different quadrants and regions of cortical bone and compares the frequency of osteocyte apoptosis to regional factors associated with bone remodeling. Specifically, the quantity of apoptosis was compared to levels of the bone morphagenic protein antagonists noggin and gremlin. Samples of unloaded right tibial bone obtained from C57/Bl/6 mice underwent TUNEL staining for apoptotic osteocytes and were counterstained with methyl green to ...


Sar Map Of Gel Phantom In A 64mhz Mri Birdcage By Fiber-Optic Thermometry And Fdtd Simulation, Chirag Mukesh Patel 2011 California Polytechnic State University - San Luis Obispo

Sar Map Of Gel Phantom In A 64mhz Mri Birdcage By Fiber-Optic Thermometry And Fdtd Simulation, Chirag Mukesh Patel

Master's Theses and Project Reports

As implantable medical devices are being used more often to treat medical problems for which pharmaceuticals don’t suffice, it is important to understand their interactions with commonly used medical modalities. The interactions between medical implants and Magnetic Resonance Imaging machines have proven to be a risk for patients with implants.

Implanted medical devices with elongated metallic components can create harmful levels of local heating in a Magnetic Resonance Imaging (MRI) environment [1]. The heating of a biological medium under MRI is monitored via the Specific Absorption Rate (SAR). SAR, defined as power absorbed per unit mass (W/kg), can ...


New Tools For Monitoring Gamma Camera Uniformity, Brad K. Lofton 2010 University of Texas Graduate School of Biomedical Sciences at Houston

New Tools For Monitoring Gamma Camera Uniformity, Brad K. Lofton

UT GSBS Dissertations and Theses (Open Access)

Detector uniformity is a fundamental performance characteristic of all modern gamma camera systems, and ensuring a stable, uniform detector response is critical for maintaining clinical images that are free of artifact. For these reasons, the assessment of detector uniformity is one of the most common activities associated with a successful clinical quality assurance program in gamma camera imaging. The evaluation of this parameter, however, is often unclear because it is highly dependent upon acquisition conditions, reviewer expertise, and the application of somewhat arbitrary limits that do not characterize the spatial location of the non-uniformities. Furthermore, as the goal of any ...


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