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Drug-Loaded Chitosan Film Prepared Via Facile Solution Casting And Air-Drying Of Plain Water-Based Chitosan Solution For Ocular Drug Delivery, Boxuan Li, Juan Wang, Qin Gui, Hu Yang 2020 Missouri University of Science and Technology

Drug-Loaded Chitosan Film Prepared Via Facile Solution Casting And Air-Drying Of Plain Water-Based Chitosan Solution For Ocular Drug Delivery, Boxuan Li, Juan Wang, Qin Gui, Hu Yang

Chemical and Biochemical Engineering Faculty Research & Creative Works

Chitosan is a nature-based polymer with low toxicity, excellent biocompatibility and biodegradability. However, the intractable solubility of chitosan in water and most conventional solvents hampers its biomedical applications. Following the dissolution method for dissolving chitosan in plain water developed by us, chitosan was dissolved in ionic liquid followed by overnight freezing at −20 °C and subsequent solvent exchange with plain water at room temperature. In this study, we fabricated a drug-carrying chitosan film via solution casting and air-drying by using the plain water-based chitosan solution. Specifically, brimonidine tartrate (BT), an antiglaucoma drug, was dissolved in the plain-water based solution and ...


A Review Paper: Analysis Of Weka Data Mining Techniques For Heart Disease Prediction System, Basma Jumaa Saleh, Ahmed Yousif Falih Saedi, Ali Talib Qasim al-Aqbi, Lamees abdalhasan Salman 2020 Al-Mustansiriyah University

A Review Paper: Analysis Of Weka Data Mining Techniques For Heart Disease Prediction System, Basma Jumaa Saleh, Ahmed Yousif Falih Saedi, Ali Talib Qasim Al-Aqbi, Lamees Abdalhasan Salman

Library Philosophy and Practice (e-journal)

Data mining is characterized as searching for useful information through very large data sets. Some of the key and most common techniques for data mining are association rules, classification, clustering, prediction, and sequential models. For a wide range of applications, data mining techniques are used. Data mining plays a significant role in disease detection in the health care industry. The patient should be needed to detect a number of tests for the disease. However, the number of tests should be reduced by using data mining techniques. In time and performance, this reduced test plays an important role. Heart disease is ...


A Brief Bibliometric Survey On Circularly Polarized Antennas For Mobile Communication, ANIKET GUNJAL, Abhaya Pal Singh 2020 Symbiosis International University

A Brief Bibliometric Survey On Circularly Polarized Antennas For Mobile Communication, Aniket Gunjal, Abhaya Pal Singh

Library Philosophy and Practice (e-journal)

This paper presents a database review on “Circularly Polarized Antennas for Mobile Communication” as it is the emerging technique used by mobile service provider because of having benefits over other types of antennas available.The polarization purity is now the major issue. In some cases due to cross polarization issue the antenna signal is cancelled at receiver side.So, it is necessary to have circularly polarized antenna to avoid this polarization issue because of change in phase of signal. The change in phase of signal is due to striking of wave on the obstacles and it slightly tilted from its ...


Cytomegalovirus Inhibition By Pluronic-Encapsulated Quercetin And Synergy With Ganciclovir, Ian Wadsworth 2020 Utah State University

Cytomegalovirus Inhibition By Pluronic-Encapsulated Quercetin And Synergy With Ganciclovir, Ian Wadsworth

All Graduate Theses and Dissertations

Congenital cytomegalovirus (CMV) is the leading viral cause of birth defects worldwide and leads to a variety of complications. Ganciclovir is the most common anti-CMV drug used but often causes severe side effects. Quercetin, a plant pigment, shows anti-CMV activity that may provide a less toxic alternative to ganciclovir, or when co-administered, reduce ganciclovir treatments. However, a drug carrier is needed to deliver quercetin for CMV treatment. In this study, three Pluronic polymers (P123, F127, and F68) were investigated as a quercetin drug delivery system (DDS) for CMV treatment.

All selected Pluronics successfully encapsulated quercetin at varying degrees of efficacy ...


Characterization Of Chinese Hamster Ovary Cell Performance With Pentanoic Acid And N-Acetyl Cysteine Treatment, Joseph Camire 2020 Utah State University

Characterization Of Chinese Hamster Ovary Cell Performance With Pentanoic Acid And N-Acetyl Cysteine Treatment, Joseph Camire

All Graduate Theses and Dissertations

To improve the cost of producing protein therapeutics manufacturers can attempt to increase the amount of protein produced per unit volume. Some small fatty-acids have shown the ability to increase protein concentrations in some manufacturing systems. An example system is in the industrially important cell line derived from a Chinese Hamster Ovary (CHO). A drawback of adding these fatty-acids is they can increase the rate of cell death.

A potential way to minimize the cell death rate, caused by adding fatty-acids, is to also add additional anti-oxidants. Through a series of studies, we demonstrate production with different fatty-acids, butanoic acid ...


Protecting Crops From Abiotic Stress: Copper Oxide Nanoparticle Effects On Wheat And A Beneficial Rhizobacterium, Matthew Potter 2020 Utah State University

Protecting Crops From Abiotic Stress: Copper Oxide Nanoparticle Effects On Wheat And A Beneficial Rhizobacterium, Matthew Potter

All Graduate Theses and Dissertations

Nanoparticles (NPs) are defined as particles less than 100 nm in at least one dimension. CuO NPs have possible applications in agriculture as micronutrient sources, pesticides, and enhancers of crop stress tolerance. Here, three aspects of CuO NP agricultural applications are studied: 1) the potential of CuO NPs to prevent wheat lodging-when crops irreversibly fall over; 2) CuO NP-induced drought tolerance in wheat seedlings; and 3) the effects of CuO NPs on outer membrane vesicle (OMV) production by Pseudomonas chlororaphis O6 (PcO6), a plant-health promoting bacterium.

Wheat grown 7 d exposed to CuO NPs in the growth matrix exhibited increased ...


Alternate Warfare: The Unseen Weapons Of Mass Destruction, Elyse Keener 2020 Liberty University

Alternate Warfare: The Unseen Weapons Of Mass Destruction, Elyse Keener

Liberty University Journal of Statesmanship & Public Policy

Biological warfare is a national security concern that transcends centuries. In the current international climate, biowarfare is of particular interest due to the COVID-19 pandemic. This article seeks to follow historical cases of biological warfare and international response to these cases in order to understand the implications of COVID-19, if it were to be weaponized. Also covered is the current capabilities that Russia, China, and Iran are assessed to possess.


Research Of Features And Compositions Of Vermiculite For Use As Suspension Fire Retardant For Textile Materials, I.N. Khaidarov, R.I. Ismailov 2020 Tashkent State Technical University

Research Of Features And Compositions Of Vermiculite For Use As Suspension Fire Retardant For Textile Materials, I.N. Khaidarov, R.I. Ismailov

Technical science and innovation

This article presents studies of fire resistance in the treatment of expanded vermiculite, which depends on the size of the dispersed particles and the orientation of the granules, their moisture and temperature. It has been studied that one of the interesting and important in practice properties of vermiculite is its ability to swell and turn into a lightweight effective material for imparting fire resistance. The properties and compositions of vermiculite from the Tebinbulak deposit are studied, from which a flame-retardant suspension is prepared for processing textile materials based on vermiculite dissolved in orthophosphoric acid and alkali in an aqueous medium ...


Changes In Lumbo-Pelvic Coordination Of Individuals With And Without Low Back Pain When Wearing A Hip Orthosis, Matthew T. Ballard, Colin Drury, Babak Bazrgari 2020 University of Kentucky

Changes In Lumbo-Pelvic Coordination Of Individuals With And Without Low Back Pain When Wearing A Hip Orthosis, Matthew T. Ballard, Colin Drury, Babak Bazrgari

Biomedical Engineering Faculty Publications

Individuals with low back pain demonstrate an abnormal lumbo-pelvic coordination compared to back-healthy individuals. This abnormal coordination presents itself as a reduction in lumbar contributions and an increase in pelvic rotations during a trunk forward bending and backward return task. This study investigated the ability of a hip orthosis in correcting such an abnormal lumbo-pelvic coordination by restricting pelvic rotation and, hence increasing lumbar contributions. The effects of the hip orthosis on the lumbo-pelvic coordination were investigated in 20 low back pain patients and 20 asymptomatic controls. The orthosis reduced pelvic rotation by 12.7° and increased lumbar contributions by ...


Anti-Crispr Proteins: Applications In Genome Engineering, Jooyoung Lee 2020 University of Massachusetts Medical School

Anti-Crispr Proteins: Applications In Genome Engineering, Jooyoung Lee

GSBS Dissertations and Theses

Clustered, regularly interspaced, short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) constitute a bacterial and archaeal adaptive immune system. The ongoing arms race between prokaryotic hosts and their invaders such as phages led to the emergence of anti-CRISPR proteins as countermeasures against the potent antiviral defense. Since the first examples of anti-CRISPRs were shown in a subset of CRISPR-Cas systems, we endeavored to uncover these naturally-occurring inhibitors that inactivate different types of CRISPR-Cas systems. In the first part of my thesis, we have identified and characterized Type II anti-CRISPR proteins that inactivate several Cas9 orthologs. We share mechanistic insights into anti-CRISPR ...


Measurement And Modeling Of The Effects Of Transcranial Magnetic Stimulation On The Brain, Oluwaponmile F. Afuwape, Hiroyuki Oya, Aaron D. Boes, David C. Jiles 2020 Iowa State University

Measurement And Modeling Of The Effects Of Transcranial Magnetic Stimulation On The Brain, Oluwaponmile F. Afuwape, Hiroyuki Oya, Aaron D. Boes, David C. Jiles

Electrical and Computer Engineering Publications

Transcranial Magnetic Stimulation (TMS) is a method of non-invasively modulating the excitability of the brain. TMS relies on the principle of electromagnetic induction in producing an electric field that stimulates neurons. Measuring the effect of TMS in real time and being able to determine its spatiotemporal resolution increase its potential in both research and clinical applications. In this paper, the authors model the electric fields of three TMS coils: Quadruple Butterfly Coil (QBC), Triple Halo Coil (THC) and the Magventure B65 coils, by performing computational finite element (FE) analysis using the Sim4life software. To evaluate the accuracy of the electromagnetic ...


Transport Of Artificial Virus-Like Nanocarriers (Avn) Through Intestinal Monolayer Via Microfold Cells, Tianjian Tong, Yijun Qi, Luke Bussiere, Michael J. Wannemeuhler, Cathy L. Miller, Chenxu Yu, Qun Wang 2020 Iowa State University

Transport Of Artificial Virus-Like Nanocarriers (Avn) Through Intestinal Monolayer Via Microfold Cells, Tianjian Tong, Yijun Qi, Luke Bussiere, Michael J. Wannemeuhler, Cathy L. Miller, Chenxu Yu, Qun Wang

Agricultural and Biosystems Engineering Publications

Compared with subcutaneous or intramuscular routes for vaccination, vaccine delivery via gastrointestinal mucosa has tremendous potential as it is easy to administer and pain free. Robust immune responses can be triggered successfully once vaccine carried antigen reaches the mucosal associated lymphoid sites (e.g., Peyer’s patches). However, the absence of an efficient delivery method has always been an issue for successful oral vaccine development. In our study, inspired by mammalian orthoreovirus (MRV) transport into gut mucosal lymphoid tissue via Microfold cells (M cells), artificial virus-like nanocarriers (AVN), consisting of gold nanocages functionalized with the 1 protein from mammalian reovirus ...


Β-Amyloid And Tau Drive Early Alzheimer's Disease Decline While Glucose Hypometabolism Drives Late Decline, Tyler C. Hammond, Xin Xing, Chris Wang, David Ma, Kwangsik Nho, Paul K. Crane, Fanny Elahi, David A. Ziegler, Gongbo Liang, Qiang Cheng, Lucille M. Yanckello, Nathan Jacobs, Ai-Ling Lin 2020 University of Kentucky

Β-Amyloid And Tau Drive Early Alzheimer's Disease Decline While Glucose Hypometabolism Drives Late Decline, Tyler C. Hammond, Xin Xing, Chris Wang, David Ma, Kwangsik Nho, Paul K. Crane, Fanny Elahi, David A. Ziegler, Gongbo Liang, Qiang Cheng, Lucille M. Yanckello, Nathan Jacobs, Ai-Ling Lin

Sanders-Brown Center on Aging Faculty Publications

Clinical trials focusing on therapeutic candidates that modify β-amyloid (Aβ) have repeatedly failed to treat Alzheimer’s disease (AD), suggesting that Aβ may not be the optimal target for treating AD. The evaluation of Aβ, tau, and neurodegenerative (A/T/N) biomarkers has been proposed for classifying AD. However, it remains unclear whether disturbances in each arm of the A/T/N framework contribute equally throughout the progression of AD. Here, using the random forest machine learning method to analyze participants in the Alzheimer’s Disease Neuroimaging Initiative dataset, we show that A/T/N biomarkers show varying importance in ...


Automatic Detection Of Dynamic And Static Activities Of The Older Adults Using A Wearable Sensor And Support Vector Machines, Jian Zhang, Rahul Soangra, Thurmon E. Lockhart 2020 Glassdoor

Automatic Detection Of Dynamic And Static Activities Of The Older Adults Using A Wearable Sensor And Support Vector Machines, Jian Zhang, Rahul Soangra, Thurmon E. Lockhart

Physical Therapy Faculty Articles and Research

Although Support Vector Machines (SVM) are widely used for classifying human motion patterns, their application in the automatic recognition of dynamic and static activities of daily life in the healthy older adults is limited. Using a body mounted wireless inertial measurement unit (IMU), this paper explores the use of an SVM approach for classifying dynamic (walking) and static (sitting, standing and lying) activities of the older adults. Specifically, data formatting and feature extraction methods associated with IMU signals are discussed. To evaluate the performance of the SVM algorithm, the effects of two parameters involved in SVM algorithm—the soft margin ...


Analysis Of Information Security Methods In Biosystems And Application Of Intelligent Tools In Information Security Systems, Sherzod Sayfullaev 2020 Tashkent University of Information Technologies named after Muhammad al-Khwarizmi Address: 108, Amir Temur st., 100200, Tashkent city, Republic of Uzbekistan E-mail: sherzodsay@gmail.com, Phone:+998-91-162-42-70.

Analysis Of Information Security Methods In Biosystems And Application Of Intelligent Tools In Information Security Systems, Sherzod Sayfullaev

Chemical Technology, Control and Management

In this paper, the methods of information protection in bio systems are studied. The paper considers the use of intelligent tools in information security systems and the use of adaptive information security systems. Several articles on the field of information protection in bio systems are analyzed. Disadvantages and advantages of neural network technologies in modern information security systems are described. The characteristics of bio systems and the specificity of DNA, the main features of the DNA code that provide information security and functional stability of bio systems data protection structure. Application of intelligent tools to create a comprehensive adaptive protection ...


A Comparative Study Of Sleep And Diurnal Patterns In House Mouse (Mus Musculus) And Spiny Mouse (Acomys Cahirinus), Chanung Wang, Lauren E. Guerriero, Dillon M. Huffman, Asma'a A. Ajwad, Trae C. Brooks, Sridhar Sunderam, Ashley W. Seifert, Bruce F. O'Hara 2020 University of Kentucky

A Comparative Study Of Sleep And Diurnal Patterns In House Mouse (Mus Musculus) And Spiny Mouse (Acomys Cahirinus), Chanung Wang, Lauren E. Guerriero, Dillon M. Huffman, Asma'a A. Ajwad, Trae C. Brooks, Sridhar Sunderam, Ashley W. Seifert, Bruce F. O'Hara

Biomedical Engineering Faculty Publications

Most published sleep studies use three species: human, house mouse, or Norway rat. The degree to which data from these species captures variability in mammalian sleep remains unclear. To gain insight into mammalian sleep diversity, we examined sleep architecture in the spiny basal murid rodent Acomys cahirinus. First, we used a piezoelectric system validated for Mus musculus to monitor sleep in both species. We also included wild M. musculus to control for alterations generated by laboratory-reared conditions for M. musculus. Using this comparative framework, we found that A. cahirinus, lab M. musculus, and wild M. musculus were primarily nocturnal, but ...


Comparison Of The Effect Of Coil Configuration And The Variability Of Anatomical Structure On Transcranial Magnetic Stimulation, Oluwaponmile F. Afuwape, Priyam Rastogi, David C. Jiles 2020 Iowa State University

Comparison Of The Effect Of Coil Configuration And The Variability Of Anatomical Structure On Transcranial Magnetic Stimulation, Oluwaponmile F. Afuwape, Priyam Rastogi, David C. Jiles

Electrical and Computer Engineering Publications

Transcranial Magnetic Stimulation (TMS) is a non-invasive therapeutic and restorative mode of treating neurological disorders which has been approved by the United States Food and Drug Administration (FDA). It has proven to be an effective way of treating disorders as it is a less risky technology compared to conventional brain surgery. Various researchers have proposed coil designs for TMS aimed at achieving high focality and increased penetration depth of the induced electric field in the brain. In the present research, the authors compare the Figure of Eight (FOE) coil, Quadruple Butterfly Coil (QBC) and Triple Halo Coil (THC) on different ...


Understanding And Overcoming Empathy Walls: The First Steps Toward Civic Conversation, Adriana J. Deras, Angelle Leger, Abdullah Alturaifi, Jacqueline Begue, James Blake, Christopher Bologna, Leandre Bonmardion, Valentino Browning, Christopher Charleston, Ann Clark, Amber Cradeur, Kenzie Dupont, Jarred Favrot, Faye Foret, Brett Fulmer, Tanishq Goribidanur, Sayma Hanif, Savannah Heath, Matthew Hutchins, Nathan Istre, Gracie Kennard, Gabrielle Kerkow, Sayou Ketcha, Kallie Kilchrist, Timothy King, Akua Kumi, Meggie Lam, Tiffany Le, Zachary Lehmann, Spencer Lemoine, Andy Lin, Zoe Martin, John Marzullo, Cameron Matherne, Laura Moldovan, Adriana Montoya, Michelle Opiri, Shivani Pandya, Victoria Parsley, Brogan Pathi, Kendall Raymond, Jordan Remont, Sydne Rigby, Barrick Roberts, Trey Schexnayder, Samantha Seetharama, Prianca Shrestha, Meghan Sills, Jhacory Simien, L. Elena Soto Handel, Jonathan Thomas, Austin Veal, Britt Young 2020 Louisiana State University

Understanding And Overcoming Empathy Walls: The First Steps Toward Civic Conversation, Adriana J. Deras, Angelle Leger, Abdullah Alturaifi, Jacqueline Begue, James Blake, Christopher Bologna, Leandre Bonmardion, Valentino Browning, Christopher Charleston, Ann Clark, Amber Cradeur, Kenzie Dupont, Jarred Favrot, Faye Foret, Brett Fulmer, Tanishq Goribidanur, Sayma Hanif, Savannah Heath, Matthew Hutchins, Nathan Istre, Gracie Kennard, Gabrielle Kerkow, Sayou Ketcha, Kallie Kilchrist, Timothy King, Akua Kumi, Meggie Lam, Tiffany Le, Zachary Lehmann, Spencer Lemoine, Andy Lin, Zoe Martin, John Marzullo, Cameron Matherne, Laura Moldovan, Adriana Montoya, Michelle Opiri, Shivani Pandya, Victoria Parsley, Brogan Pathi, Kendall Raymond, Jordan Remont, Sydne Rigby, Barrick Roberts, Trey Schexnayder, Samantha Seetharama, Prianca Shrestha, Meghan Sills, Jhacory Simien, L. Elena Soto Handel, Jonathan Thomas, Austin Veal, Britt Young

Journal of Community Engagement and Scholarship

No abstract provided.


How Does Robotic Surgery Influence Communication, Leadership, And Team Outcomes? A Multimethod Examination., Jordan E. Rogers 2020 Embry-Riddle Aeronautical University

How Does Robotic Surgery Influence Communication, Leadership, And Team Outcomes? A Multimethod Examination., Jordan E. Rogers

Dissertations and Theses

The practice of delivering surgical care has evolved to be less invasive to the patients undergoing surgery. Minimally-invasive surgery can be practiced through traditional laparoscopic methods as well as with robotic technology that displaces the surgeon from the operating table. Robotic surgery has been cited to be safer and more effective than traditional laparoscopic surgery; however, little research has endeavored to investigate the role of surgical modality upon aspects of teamwork. This dissertation contributes to the human factors and teamwork literature by evaluating how surgical modality may influence communication, shared leadership, and team outcomes. Multiple methods were employed to study ...


Secretion Of Proteins And Antibody Fragments From Transiently Transfected Endothelial Progenitor Cells, Loree Heller, Reynald Thinard, Melanie Chevalier, Sezgi Arpag, Yu Jing, Ruth Greferath, Richard Heller, Claude Nicolau 2020 Old Dominion University

Secretion Of Proteins And Antibody Fragments From Transiently Transfected Endothelial Progenitor Cells, Loree Heller, Reynald Thinard, Melanie Chevalier, Sezgi Arpag, Yu Jing, Ruth Greferath, Richard Heller, Claude Nicolau

Bioelectrics Publications

In neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, multiple sclerosis and amyotrophic lateral sclerosis, neuroinflammation can lead to blood-brain barrier (BBB) breakdown. After intravenous or intra-arterial injection into mice, endothelial progenitor cells (EPCs) home to the damaged BBB to promote neurovascular repair. Autologous EPCs transfected to express specific therapeutic proteins offer an innovative therapeutic option. Here, we demonstrate that EPC transfection by electroporation with plasmids encoding the reporter protein GFP or an anti-beta-amyloid antibody fragment (Fab) leads to secretion of each protein. We also demonstrate the secreted anti-beta-amyloid Fab protein functions in beta-amyloid aggregate solubilization.


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