Shape Memory Alloy Capsule Micropump For Drug Delivery Applications, 2024 American University in Cairo
Shape Memory Alloy Capsule Micropump For Drug Delivery Applications, Youssef Mohamed Kotb
Theses and Dissertations
Implantable drug delivery devices have many benefits over traditional drug administration techniques and have attracted a lot of attention in recent years. By delivering the medication directly to the tissue, they enable the use of larger localized concentrations, enhancing the efficacy of the treatment. Passive-release drug delivery systems, one of the various ways to provide medication, are great inventions. However, they cannot dispense the medication on demand since they are nonprogrammable. Therefore, active actuators are more advantageous in delivery applications. Smart material actuators, however, have greatly increased in popularity for manufacturing wearable and implantable micropumps due to their high energy …
The Effect Of A Constitutive Formulation On Limb Flexion-Induced Stresses In The Human Femoropopliteal Artery: A Patient-Specific Study, 2024 University of Nebraska at Omaha
The Effect Of A Constitutive Formulation On Limb Flexion-Induced Stresses In The Human Femoropopliteal Artery: A Patient-Specific Study, Ali Ahmadi, Anastasia Desyatova
UNO Student Research and Creative Activity Fair
The Effect of a Constitutive Formulation on Limb Flexion-Induced Stresses in the Human Femoropopliteal Artery: a Patient-Specific Study
Peripheral arterial disease (PAD) involves the development of atherosclerotic lesions that restrict the flow of blood to tissues downstream. The femoropopliteal artery (FPA) experiences complex mechanical deformations during daily activities, potentially contributing to the prevalence of PAD and unfavorable treatment outcomes. These deformations generate significant intramural stresses and strains, resulting in arterial injury, disease progression, and restenosis following treatment. Computational modeling offers a way to improve the repair of the FPA; however, the accuracy of these simulations relies on the selection of …
Modes Of Fracture Of Flat Bone: Fracture Direction And Stress, 2024 Pepperdine University
Modes Of Fracture Of Flat Bone: Fracture Direction And Stress, Nolan Wang, Mary K. Holden, Everett Baker, Nathaniel Lerch, Nate Fitch
Seaver College Research And Scholarly Achievement Symposium
This study delineates the application of fractography to discern the multifaceted modes of fracture in flat bones, explicating the interplay between fracture directionality and stress states regarding the viscoelastic nature of bone. Despite the perceived brittleness, bone exhibits toughness, attributed to its intricate structure design and amalgamating properties of solid and viscous materials. This research elucidates the variegated fracture modes inherent to bone's dualistic nature by examining fracture surfaces and identifying fracture markings using stereoscopic microscopy. Our observations across seven bone specimens reveal predominant fracture patterns from top to bottom in six instances, with a singular deviation where the fracture …
Tracking Simulated Somatosensory Deficiencies That Affect Postural Stability Through Detrended Fluctuation Analysis, 2024 Olivet Nazarene University
Tracking Simulated Somatosensory Deficiencies That Affect Postural Stability Through Detrended Fluctuation Analysis, Cameron L. Steele
ELAIA
Falls are a prevalent problem among elderly populations. Falls increase the cost of healthcare, frequently cause severe injuries, and negatively affect quality of life. Lack of postural stability is a major contributing factor to falls, with postural stability defined as the correct biomechanical execution based on sensory feedback. Types of sensory feedback include vision, vestibular, proprioceptive, and somatosensory. This study focuses on the lack of postural stability in quiet standing (standing upright and still) due to somatosensory and vision deficiencies. To track these deficiencies, fifty-one subjects stood for sixty seconds on two force plates, and their center of pressure (COP) …
6d Single-Fluorogen Orientation-Localization Microscopy For Elucidating The Architecture Of Beta-Sheet Assemblies And Biomolecular Condensates, 2024 Washington University in St. Louis
6d Single-Fluorogen Orientation-Localization Microscopy For Elucidating The Architecture Of Beta-Sheet Assemblies And Biomolecular Condensates, Tingting Wu, Weiyan Zhou, Jai S. Rudra, Rohit V. Pappu, Matthew D. Lew
Electrical & Systems Engineering Publications and Presentations
We develop six-dimensional single-molecule orientation-localization microscopy (SMOLM) to measure the 3D positions and 3D orientations simultaneously of single fluorophores. We show how careful optimization of phase and polarization modulation components can encode phase, polarization, and angular spectrum information from each fluorescence photon into a microscope’s dipole-spread function. We used the transient binding and blinking of Nile red (NR) to characterize the helical structure of fibrils formed by designed amphipathic peptides, KFE8L and KFE8D, and the pathological amyloid-beta peptide Aβ42. We also deployed merocyanine 540 to uncover the interfacial architectures of biomolecular condensates.
Development And Characterization Of Injectable, Cell-Encapsulated Chitosan-Genipin Hydrogels, 2024 Louisiana Tech University
Development And Characterization Of Injectable, Cell-Encapsulated Chitosan-Genipin Hydrogels, Tyler R. Priddy-Arrington
Doctoral Dissertations
Over 150,000 patients undergo lower extremity amputation every year in the United States, most commonly caused by complications due to diabetes mellitus, peripheral vascular disease, and trauma. Diseased or damaged tissues that are unable to naturally repair themselves must either be fully removed or replaced, otherwise the injuries can lead to further complications such as infection or death. Tissue resection and amputation, as forms of removing damaged tissue, are not favorable to patients as they can cause pain, reduce mobility, and negatively impact quality of life. However, replacing lost or damaged tissues with donor tissues carries the risks of tissue …
Blow-Spun Hybrid Pcl-Peo/Hnts Scaffolds With Enhanced Biological And Mechanical Properties, 2024 Louisiana Tech University
Blow-Spun Hybrid Pcl-Peo/Hnts Scaffolds With Enhanced Biological And Mechanical Properties, Meichen Liu
Doctoral Dissertations
With the development of technology and engineering, nanotechnology has been a multidisciplinary scientific field applied in nearly all science areas, including medicine, genetics, food industry, robotics. In this respect, nanomedicine has gained increasing attention and been a useful, effective therapy for cancer diagnosis, gene transfer, and drug delivery. To design an ideal nano drug delivery system with controlled drug releasing and improved encapsulated drug’s pharmacokinetic and pharmacodynamic profiles, hydrogels and polymer composites have witnessed increased research interest during the last decades. Recently, numerous polymers have been studied to fabricate the ideal wound dressing with biocompatibility, biodegradability, porous structural, and suitable …
Selective Targeting Of Microglia By Quantum Dots And Green Synthesis Of Metal Organic Biohybrids; Applications In Dynamic Cell And Assay Systems, 2024 Louisiana Tech University
Selective Targeting Of Microglia By Quantum Dots And Green Synthesis Of Metal Organic Biohybrids; Applications In Dynamic Cell And Assay Systems, Navya Uppu
Doctoral Dissertations
Neurological disorders are the leading cause of physical and cognitive disability across the globe, currently affecting approximately 15% of the worldwide population. Part of the glioma microenvironment are microglia, resident immune cells of the CNS that were thought to be involved in the pathogenesis of diverse neurodegenerative diseases. Though it remains uncertain what triggers microglial activation in these disorders, targeting and tracking microglial functions using nanotools like Quantum Dots (QDs) could help us elucidate them in such neurological diseases. This research focuses on the comparative study of different QDs formulations and their selective uptake by brain microglia in primary cultures …
Interpatient Differences In Neural Recruitment Patterns During Pudendal Nerve Stimulation – A Computational Investigation, 2024 Wayne State University
Interpatient Differences In Neural Recruitment Patterns During Pudendal Nerve Stimulation – A Computational Investigation, Amolak S. Jhand, Luis C. Ruiz, Nystha Baishya, Ehsan Mirzakhalili, Gaurang Shah, Priyanka Gupta, Tim M. Bruns, Scott F. Lempka
Medical Student Research Symposium
Bladder dysfunction impairs the quality of life for millions of individuals around the world. Common causes of bladder dysfunction include aging, trauma, and neurological disorders. Due to inadequacies in conventional treatments, neuromodulation therapies to address bladder dysfunction, such as sacral nerve stimulation, have emerged. However, patient needs still remain unmet. Pudendal nerve stimulation (PNS) has recently gained clinical interest as a promising treatment for bladder dysfunction. While PNS has been extensively investigated in preclinical settings, there is a gap in our understanding of the mechanisms of action and efficacy of PNS as limited studies of PNS have been performed on …
Modified Zero-Gravity Chair In The Management Of Pain And Anxiety With Emphasis On Pre And Post Anesthesia For Surgical Procedures, 2024 Roseman University of Health Sciences
Modified Zero-Gravity Chair In The Management Of Pain And Anxiety With Emphasis On Pre And Post Anesthesia For Surgical Procedures, Alexander Tisdale, Kinsley Batson, Zachary Jamous, Isabella Termini, Kyle Mooday, Matt Cohn, Jackson Justice
Annual Research Symposium
The purpose of this research is the integration of a zero-gravity chair with planar vibration as a non-pharmaceutical approach to preoperative anxiety and postoperative pain management. The treatment plan involves preoperative familiarization with the chair's vibrational patterns and postoperative use for pain relief. Integration of this approach holds promise in reshaping postoperative care paradigms, advocating for personalized, holistic interventions to enhance patient well-being and mitigate opioid-related risks.
Mri Image Regression Cnn For Bone Marrow Lesion Volume Prediction, 2024 Rowan University
Mri Image Regression Cnn For Bone Marrow Lesion Volume Prediction, Kevin Yanagisawa
Theses and Dissertations
Bone marrow lesions (BMLs), occurs from fluid build up in the soft tissues inside your bone. This can be seen on magnetic resonance imaging (MRI) scans and is characterized by excess water signals in the bone marrow space. This disease is commonly caused by osteoarthritis (OA), a degenerative join disease where tissues within the joint breakdown over time [1]. These BMLs are an emerging target for OA, as they are commonly related to pain and worsening of the diseased area until surgical intervention is required [2]–[4]. In order to assess the BMLs, MRIs were utilized as input into a regression …
Correlation Enhanced Distribution Adaptation For Prediction Of Fall Risk, 2024 The State University of New York at Binghamton
Correlation Enhanced Distribution Adaptation For Prediction Of Fall Risk, Ziqi Guo, Teresa Wu, Thurmon Lockhart, Rahul Soangra, Hyunsoo Yoon
Physical Therapy Faculty Articles and Research
With technological advancements in diagnostic imaging, smart sensing, and wearables, a multitude of heterogeneous sources or modalities are available to proactively monitor the health of the elderly. Due to the increasing risks of falls among older adults, an early diagnosis tool is crucial to prevent future falls. However, during the early stage of diagnosis, there is often limited or no labeled data (expert-confirmed diagnostic information) available in the target domain (new cohort) to determine the proper treatment for older adults. Instead, there are multiple related but non-identical domain data with labels from the existing cohort or different institutions. Integrating different …
A Fractal Art Approach To The Three-Body Problem, 2024 Purdue University
A Fractal Art Approach To The Three-Body Problem, Charles F. Babbs
Weldon School of Biomedical Engineering Faculty Working Papers
This preliminary study explores a new search strategy for identifying relatively stable vs. unstable solutions to the planar three-body problem in astrophysics, starting from the perspective of computer-generated art. Here classical Newtonian accelerations, speeds, and positions of all three bodies in a fixed plane are calculated. All three bodies are stationary at time zero, and the fate of the system is classified as reflecting either a bound stable orbit, a likely collision, or the ejection of one body. The initial position of one of the three bodies is varied in the image plane, and the outcome coded as one of …
Multimode Point Spectroscopy For Food Authentication, 2024 University of North Dakota
Multimode Point Spectroscopy For Food Authentication, Sayed Asaduzzaman, Nicholas Mackinnon, Hossein Kashani Zadeh
SDSU Data Science Symposium
Enhancing food quality measurement is a necessity to guarantee food safety and adherence to health regulations. Current methods involve lab testing which are time-consuming, costly, destructive and require skilled workers. Spectroscopy has the potential to overcome these challenges. This study employs a multi-mode point spectroscopy method to distinguish food products according to their spectral characteristics,. The system records fluorescence, excited at 365 and 405 nm, visible-near infrared (Vis-NIR) and short-wave infrared (SWIR) spectra. The three main subjects of the study are olive oil, milk, and honey. Samples were kept in a transparent cell culture pot, and Gray and White Spectralon …
Left Ventricle Function And Post-Transcriptional Events With Exercise Training In Pigs, 2024 University of South Carolina
Left Ventricle Function And Post-Transcriptional Events With Exercise Training In Pigs, Stephanie L. Samani, Shayne C. Barlow, Lisa A. Freeburg, Traci L. Jones, Marlee Poole, Mark A. Sarzynski, Michael R. Zile, Tarek Shazly, Francis G. Spinale
Faculty Publications
Background
Standardized exercise protocols have been shown to improve overall cardiovascular fitness, but direct effects on left ventricular (LV) function, particularly diastolic function and relation to post-transcriptional molecular pathways (microRNAs (miRs)) are poorly understood. This project tested the central hypothesis that adaptive LV remodeling resulting from a large animal exercise training protocol, would be directly associated with specific miRs responsible for regulating pathways relevant to LV myocardial stiffness and geometry.
Methods and results
Pigs (n = 9; 25 Kg) underwent a 4 week exercise training protocol (10 degrees elevation, 2.5 mph, 10 min, 5 days/week) whereby LV chamber stiffness (KC) …
Mathematical Model Of Oxygen, Nutrient, And Drug Transport In Tuberculosis Granulomas, 2024 Massachusetts General Hospital
Mathematical Model Of Oxygen, Nutrient, And Drug Transport In Tuberculosis Granulomas, Meenal Datta, Mccarthy Kennedy, Saeed Siri, Laura Via, James W. Baish, Lei Xu, Veronique Dartois, Clifton Barry, Rakesh Jain
Faculty Journal Articles
Physiological abnormalities in pulmonary granulomas–pathological hallmarks of tuberculosis (TB)–compromise the transport of oxygen, nutrients, and drugs. In prior studies, we demonstrated mathematically and experimentally that hypoxia and necrosis emerge in the granuloma microenvironment (GME) as a direct result of limited oxygen availability. Building on our initial model of avascular oxygen diffusion, here we explore additional aspects of oxy- gen transport, including the roles of granuloma vasculature, transcapillary transport, plasma dilution, and interstitial convection, followed by cellular metabolism. Approximate analytical solutions are provided for oxygen and glucose concentration, interstitial fluid velocity, interstitial fluid pressure, and the thickness of the convective zone. …
Rational Design Of Peptide-Based Materials Informed By Multiscale Molecular Dynamics Simulations, 2024 The Graduate Center, City University of New York
Rational Design Of Peptide-Based Materials Informed By Multiscale Molecular Dynamics Simulations, Dhwanit Rahul Dave
Dissertations, Theses, and Capstone Projects
The challenge of establishing a sustainable and circular economy for materials in medicine and technology necessitates bioinspired design. Nature's intricate machinery, forged through evolution, relies on a finite set of biomolecular building blocks with through-bond and through-space interactions. Repurposing these molecular building blocks requires a seamless integration of computational modeling, design, and experimental validation. The tools and concepts developed in this thesis pioneer new directions in peptide-materials design, grounded in fundamental principles of physical chemistry. We present a synergistic approach that integrates experimental designs and computational methods, specifically molecular dynamics simulations, to gain in-depth molecular insights crucial for advancing the …
Research On An Improved Cotton Cleaner Unit, 2024 Termiz State University
Research On An Improved Cotton Cleaner Unit, Muzaffar Djurayev, Sherqul Hakimov, Ilhom Abbazov, Rashid Kaldybaev
Technical science and innovation
This article analyzes the results of changes to the working parts of a cotton cleaning unit from small and large impurities. It is known that the UXK installation uses continuous cleaning technology, that is, the cotton entering the purifier is cleaned in all its cleaning sections and then transferred to another process. In these sections, pieces of cotton wool from the separated waste are regenerated in a separate drum. Existing purifier suppliers use a manually operated mechanical system to monitor its performance. These factors do not make it possible to control the cleaning process when the quality indicators of cotton …
Myosin-Independent Stiffness Sensing By Fibroblasts Is Regulated By The Viscoelasticity Of Flowing Actin, 2024 Michigan Technological University
Myosin-Independent Stiffness Sensing By Fibroblasts Is Regulated By The Viscoelasticity Of Flowing Actin, Nikhil Mittal, Etienne B. Michels, Andrew E. Massey, Yunxiu Qiu, Shaina P. Royer-Weeden, Bryan R. Smith, Alexander X. Cartagena-Rivera, Sangyoon J. Han
Michigan Tech Publications, Part 2
The stiffness of the extracellular matrix induces differential tension within integrin-based adhesions, triggering differential mechanoresponses. However, it has been unclear if the stiffness-dependent differential tension is induced solely by myosin activity. Here, we report that in the absence of myosin contractility, 3T3 fibroblasts still transmit stiffness-dependent differential levels of traction. This myosin-independent differential traction is regulated by polymerizing actin assisted by actin nucleators Arp2/3 and formin where formin has a stronger contribution than Arp2/3 to both traction and actin flow. Intriguingly, despite only slight changes in F-actin flow speed observed in cells with the combined inhibition of Arp2/3 and myosin …
Heterologous Expression Of Arabidopsis Laccase2, Laccase4 And Peroxidase52 Driven Under Developing Xylem Specific Promoter Dx15 Improves Saccharification In Populus, 2024 Michigan Technological University
Heterologous Expression Of Arabidopsis Laccase2, Laccase4 And Peroxidase52 Driven Under Developing Xylem Specific Promoter Dx15 Improves Saccharification In Populus, Yogesh Ahlawat, Ajaya K. Biswal, Sarahani Harun, Anne E. Harman-Ware, Crissa Doeppke, Nisha Sharma, Chandrashekhar P. Joshi, Bertrand B. Hankoua
Michigan Tech Publications, Part 2
Background: Secondary cell wall holds considerable potential as it has gained immense momentum to replace the lignocellulosic feedstock into fuels. Lignin one of the components of secondary cell wall tightly holds the polysaccharides thereby enhancing the recalcitrance and complexity in the biomass. Laccases (LAC) and peroxidases (PRX) are the major phenyl-oxidases playing key functions during the polymerization of monolignols into lignin. Yet, the functions of laccase and peroxidases gene families remained largely unknown. Hence, the objective of this conducted study is to understand the role of specific LAC and PRX in Populus wood formation and to further investigate how the …